Dysphagia as a Clinical Manifestation of Monoclonal Gammopathy of Undetermined Significance: A Case Report

@article{ART002490852},
author={ Hyunjung Koo and 임선 and 박근영 and Yeonjae Han and Sangah Jeong },
title={Dysphagia as a Clinical Manifestation of Monoclonal Gammopathy of Undetermined Significance: A Case Report},
journal={대한연하장애학회지},
issn={2233-5978},
year={2019},
volume={9},
number={2},
pages={93-98},
doi={10.34160/jkds.2019.9.2.007},
url={http://dx.doi.org/10.34160/jkds.2019.9.2.007}

TY - JOUR
AU - Hyunjung Koo
AU - 임선
AU - 박근영
AU - Yeonjae Han
AU - Sangah Jeong
TI - Dysphagia as a Clinical Manifestation of Monoclonal Gammopathy of Undetermined Significance: A Case Report
T2 - 대한연하장애학회지
PY - 2019
VL - 9
IS - 2
PB - 대한연하장애학회
SP - 93-98
SN - 2233-5978
AB - Swallowing can be affected by a variety of systemic diseases. The etiology of dysphagia in the geriatric population isusually overlooked due mainly to a presumed diagnosis of presbyphagia or difficulty in revealing the direct cause. On the other hand, dysphagia can be a meaningful clinical sign of premalignant systemic disease. A 78-year-oldman, without any prior medical or family history, was admitted with the chief complaint of dysphagia with recentaspiration pneumonia. Instrumental swallowing tests revealed a severe degree of dysphagia due to decreased laryngopharyngeal sensation and weakness of the pharyngeal constrictor muscles. Extensive workup, including electromyography and laboratory tests, revealed severe sensorimotor peripheral polyneuropathy related to monoclonal gammopathy. Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant precursor of multiple myeloma, which is characterized by the proliferation of monoclonal proteins. These conditions are often associated withperipheral polyneuropathy, ataxia, and sometimes even muscle weakness. Although dysphagia can occur in othersystemic disorders, such as vasculitis or paraneoplastic syndrome-related malignancies, there are few reports of dysphagia related to MGUS. The patient was followed up for three years. The MGUS showed no further progression,but the patient showed no improvement, indicating a protracted clinical course and poor prognosis when dysphagiais related to MGUS.
KW - Deglutition disorders, Monoclonal gammopathy of undetermined significance, Paraproteinemia
DO - 10.34160/jkds.2019.9.2.007
UR - http://dx.doi.org/10.34160/jkds.2019.9.2.007
ER -

Hyunjung Koo , 임선 , 박근영 , Yeonjae Han and Sangah Jeong (2019). Dysphagia as a Clinical Manifestation of Monoclonal Gammopathy of Undetermined Significance: A Case Report. 대한연하장애학회지, 9( 2), 93- 98.

Hyunjung Koo , 임선 , 박근영 , Yeonjae Han and Sangah Jeong . 2019, “Dysphagia as a Clinical Manifestation of Monoclonal Gammopathy of Undetermined Significance: A Case Report”, 대한연하장애학회지, vol. 9, no. 2, pp. 93-98. Available from: doi:10.34160/jkds.2019.9.2.007

Hyunjung Koo 임선 et al. 박근영 Yeonjae Han Sangah Jeong “Dysphagia as a Clinical Manifestation of Monoclonal Gammopathy of Undetermined Significance: A Case Report” 대한연하장애학회지 9.2 pp. 93-98 (2019): 93.

Hyunjung Koo , 임선 , 박근영 , Yeonjae Han , Sangah Jeong . Dysphagia as a Clinical Manifestation of Monoclonal Gammopathy of Undetermined Significance: A Case Report 대한연하장애학회지 [Internet]. 2019; 9( 2), : 93-98. Available from: doi:10.34160/jkds.2019.9.2.007

Hyunjung Koo , 임선 , 박근영 , Yeonjae Han and Sangah Jeong . “Dysphagia as a Clinical Manifestation of Monoclonal Gammopathy of Undetermined Significance: A Case Report” 대한연하장애학회지 9, no.2 (2019): 93-98. doi: 10.34160/jkds.2019.9.2.007

홈 권호 목록 논문 목록 논문 상세

Dysphagia as a Clinical Manifestation of Monoclonal Gammopathy of Undetermined Significance: A Case Report

대한연하장애학회지

약어 : JKDS

2019, vol.9, no.2, pp.93 - 98

DOI : 10.34160/jkds.2019.9.2.007

발행기관 : 대한연하장애학회

연구분야 : 재활의학

Hyunjung Koo¹ , 임선² , 박근영³ , Yeonjae Han⁴ , Sangah Jeong⁵

¹Bucheon St. Mary’s Hospital

²가톨릭대학교

³Bucheon St. Mary’s Hospital

⁴Bucheon St. Mary’s Hospital

⁵Bucheon St. Mary’s Hospital

인용한 논문 수 : - 서지 간략 보기

초록

Swallowing can be affected by a variety of systemic diseases. The etiology of dysphagia in the geriatric population isusually overlooked due mainly to a presumed diagnosis of presbyphagia or difficulty in revealing the direct cause. On the other hand, dysphagia can be a meaningful clinical sign of premalignant systemic disease. A 78-year-oldman, without any prior medical or family history, was admitted with the chief complaint of dysphagia with recentaspiration pneumonia. Instrumental swallowing tests revealed a severe degree of dysphagia due to decreased laryngopharyngeal sensation and weakness of the pharyngeal constrictor muscles. Extensive workup, including electromyography and laboratory tests, revealed severe sensorimotor peripheral polyneuropathy related to monoclonal gammopathy. Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant precursor of multiple myeloma, which is characterized by the proliferation of monoclonal proteins. These conditions are often associated withperipheral polyneuropathy, ataxia, and sometimes even muscle weakness. Although dysphagia can occur in othersystemic disorders, such as vasculitis or paraneoplastic syndrome-related malignancies, there are few reports of dysphagia related to MGUS. The patient was followed up for three years. The MGUS showed no further progression,but the patient showed no improvement, indicating a protracted clinical course and poor prognosis when dysphagiais related to MGUS.

키워드

Deglutition disorders, Monoclonal gammopathy of undetermined significance, Paraproteinemia

참고문헌(10)

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