The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease
Abstract
:1. Introduction
2. Upper Airway Microbial Niches
3. The UA Microbiota
3.1. UA Microbiota in Infants
3.2. UA Microbiota in Adults
3.3. UA Microbiota in the Geriatric Population
4. UA Inflammation
5. Environmental Exposures and the UA Microbiota
5.1. Seasonal Influences
5.2. Air Pollution
5.3. Cigarette Smoke Exposure
6. Disease Pathology and Dysbiosis
6.1. UA Diseases and Dysbiosis
6.2. UAIs and Dysbiosis
7. UA Microbiota Therapeutics
8. Limitations and Future Research
9. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Healthy Population | Study | Sampling Site and Collection Method | Detected Bacteria |
---|---|---|---|
Infants | [26] | Anterior nares Nasal swab | Corynebacterium, Propionibacterium, Bifidobacterium, Streptococcus, Staphylococcus, Dolosigranulum, Moraxella |
[26] | Nasopharynx Nasopharyngeal swab | Corynebacterium, Propionibacterium, Bifidobacterium, Bacteroides, Staphylococcus, Faecalibacterium, Streptococcus, Moraxella | |
[26] | Oropharynx Oropharyngeal swab | Prevotella, Streptococcus, Vaillonella, Haemophilus, Moraxella, Neisseria | |
Adults | [31] | Anterior nares Nasal swab | Corynebacterium, Propionibacterium, Prevotella, Dolosigranulum, Staphylococcus, Streptococcus, Moraxella, Escherichia shigella |
[31] | Middle meatus Middle meatus swab | Corynebacterium, Propionibacterium, Prevotella, Dolosigranulum, Staphylococcus, Streptococcus, Moraxella, Escherichia shigella | |
[32] | Sinus Sinus swab | Corynebacterium, Propionibacterium, Prevotella, Staphylococcus, Anaerococcus, Peptoniphilus, Ralstonia | |
[9] | Nasopharynx Nasopharyngeal swab | Corynebacterium, Propionibacterium, Bifidobacterium, Prevotella, Sphingobacterium, Staphylococcus, Faecalibacterium, Streptococcus, Pseudomonas, Haemophilus | |
[9] | Oropharynx Oropharyngeal swab | Corynebacterium, Rothia, Prevotella, Porphyromonas, Streptococcus, Vaillonella, Haemophilus, Moraxella | |
Elderly | [28] | Anterior nares Nasal swab | Corynebacterium, Propionibacterium, Bifidobacterium, Prevotella, Bacteroides, Streptococcus, Staphylococcus, Vaillonella, Moraxella, Pseudomonas |
[28] | Nasopharynx Nasopharyngeal swab | Corynebacterium, Propionibacterium, Bifidobacterium, Prevotella, Bacteroides, Streptococcus, Staphylococcus, Vaillonella, Moraxella, Pseudomonas | |
[28] | Oropharynx Oropharyngeal swab | Corynebacterium, Propionibacterium, Bifidobacterium, Prevotella, Bacteroides, Streptococcus, Staphylococcus, Vaillonella, Moraxella, Pseudomonas |
Exposure | Study | Population and Sampling Site | Detected Bacteria |
---|---|---|---|
Active cigarette smoke | [30] | Adults Nasopharynx | ↓ Actinomycetaceae, ↓ Corynebacteriaceae, ↓ Coriobacteriaceae, ↑ Eggerthella, ↓ Flexibacteriaceae, ↓ Flavobacteriaceae, ↑ Porphromonadaceae, ↓ Leuconostocaceae, ↑ Erysipelotrichaceae, ↑ Aerococcaceae, ↑ Eubacteriaceae, ↑ Incertae Sedis XIII, ↑ Peptostretococcaceae, ↑ Ruminococcaceae, ↑ Lachnospiraceae I.S. spp., ↑ Anaerovorax, ↑ Dorea, ↑ Erysipelotrichaceae I.S., ↑ Eubacterium spp., ↑ Abiotrophia spp., ↓ Rhodocyclaceae, ↓ Rhodobacteraceae, ↓ Enterobacteriaceae, ↓ Alcalgenaceae, ↓ Methylophilacea, ↓ Shigella spp., ↑ Pasteurellaceae, ↑ Haemophilus spp. |
[84] | Adults Nasopharynx | ↑ Streptococcus pneumoniae, ↑ Streptococcus pyogenes, ↑ H. influenzae, ↑ M. catarrhalis | |
Passive cigarette smoke | [85] | Infants (<60 months) in the USA Nasopharynx | ↑ Streptococcus pneumoniae |
Tobacco samples from cigarettes | [86] | Cigarettes | Bacillus, Clostridium, Enterococcus, Staphylococcus, Acinetobacter, Burkholderia, Klebsiella, Pseudomonas aeruginosa, Serratia, Campylobacter, Proteus |
Air pollutants: PM2.5, PM10, SO2, NO, O3 | [87] | Healthy young adults in northeastern China Oropharynx | ↓ Prevotella, ↓ Fusobacterium, ↓ Capnocytophaga, ↓ Veillonella, ↓ Campylobacter |
Air pollutants: PM2.5, NO2 | [83] | Healthy infants Nasal swabs | ↓ Corynebacteriaceae (NO2 only) |
Air pollutants: PM2.5, PM10 | [81] | Healthy subjects in Italy Nasal cavity | (−) Rothia, (−) Corynebacterium, (−) Flavobacterium, (−) Finegoldia, (−) Oribacterium, (−) Streptococcus, (−) Neisseria, (−) Haemophilus, (−) Actinobacillus, (+) Moraxella |
[82] | Vendors at an open-air farmer’s market in China Oropharynx | ↑ Leptotrichia, ↓ Prevotella 7, ↑ Streptococcus, ↑ Staphylococcus, ↑ Haemophilus, ↑ Moraxella | |
Air pollutants: O3 | [88] | Healthy young adults in China Nasal cavity | ↑ Moraxellaceae, ↑ Pseudomonadaceae |
Household air pollutants | [89] | Healthy adults in Malawi Nasal cavity | ↓ Tropheryma, ↑ Streptococcus, ↓ Neisseria, ↑ Petrobacter |
Exposure | Study | Population and Sampling Site | Detected Bacteria |
---|---|---|---|
Chronic Rhinosinusitis (CRS) | [99] | Adults Middle meatus | ↑ Corynebacterium, ↑ Curtobacteria, ↑ Staphylococcus, ↑ Pseudomonas |
[102] | Adults Sinus | Corynebacteriaceae, Staphylococcaceae, Streptococcaceae, Pseudomonadaceae | |
[100] | Adults with nasal polyps Middle meatus | (+) Fusobacterium, (+) Streptococcus, (+) Haemophilus | |
[100] | Adults without nasal polyps Middle meatus | Corynebacterium, Staphylococcus, Alloiococcus | |
[101] | Adults Middle Meatus | ↓ Corynebacterium, ↑ Porphyromonas, ↑ Prevotella, ↑ Anaerococcus, ↑ Lactobacillus, ↑ Finegoldia, ↑ Peptoniphilus, ↑ Dialister, ↑ Parvimonas, ↓ Staphylococcus, ↓ Dolosigranulum | |
[103] | Adults Nasopharynx | ↓ Corynebacterium, ↓ Propionibacterium, ↓ Anaerococcus, ↓ Finegoldia, ↓ Peptoniphilus, ↓ Staphylococcus | |
Asthma | [104] | Adults (18–45 years old) in Korea Nasopharynx | ↓ Corynebacterium, ↓ Moraxella |
Non-Exacerbated Asthma | [105] | Adults (mean age 36 years old) Nasopharynx | ↑ Dialister |
Exacerbated Asthma | [105] | Adults (mean age 36 years old) Nasopharynx | ↑ Gardnerella, ↑ Prevotella, ↑ Alkanindiges |
Obstructive Sleep Apnea | [62] | Adults in the USA and Spain Nasopharynx | ↑ Streptococcus, ↑ Prevotella, ↑ Veillonella |
Influenza A Virus | [106] | Infants (under the age of 2 years old) Oropharynx | ↑ Streptococcus pneumoniae, ↑ Staphylococcus aureus |
[107] | Patients (up to 52 years old) Nasopharynx | ↑ Corynebacterium spp., ↑ Streptococcus, ↓ Pseudomonas | |
[108] | Children in China Nasopharynx/Oropharynx | ↑ Dolosigranulum spp., ↑ Staphylococcus aureus, ↑ Phyllobacterium spp., ↑ Moraxella spp. | |
Adenovirus | [109] | Patients (mean age 24–25 years) in South Africa Nasopharynx | ↑ Streptococcus pneumoniae |
Respiratory Syncytial Virus | [110] | Hospitalized infants (under 1 year of age) in the USA Nasopharynx | ↑ Haemophilus spp. |
SARS-CoV-2 | [111] | Elderly patients in China Oropharynx | ↑ Klebsiella pneumoniae, ↑ Enterococcus spp., ↑ Staphylococcus |
[112] | Children (7–139 months old) Posterior nasopharynx and oropharynx | ↓ Bacteroidetes, ↓ Firmicutes, ↑ Proteobacteria, ↑ Pseudomonas, ↑ Herbaspirillum, ↑ Burkholderia, and ↑ Comamonadaceae_U | |
[113] | Adults (17–68 years old) Throat swabs | ↑ Bacteroidales, ↑ Fusobacterium, ↑ Porphyromonas, ↑ Prevotella, and ↑ Neisseria | |
[114] | >18-year-old, nonhospitalized COVID-19 patients Midturbinate swab | ↑ Peptoniphilus lacrimalis, ↑ Campylobacter hominis, ↑ Prevotella 9 copri, ↑ Anaerococcus, ↓ Corynebacterium, ↓ Staphylococcus haemolyticus, ↓ Prevotella disiens, and ↓ Corynebacterium | |
Middle East Respiratory Syndrome (MERS) Coronavirus | [115] | Adults (47–74 years old) in Saudi Arabia Oropharyngeal swabs and tracheal aspirates | (+) Acinetobacter baumannii, (+) Pseudomonas aeruginosa, and (+) Streptococcus pneumoniae |
[116] | Young children (under 3 years old) in Peru Nasopharynx | ↑ Streptococcus pneumoniae, ↑ Staphylococcus aureus | |
Rhinovirus-A | [109] | Patients (mean age 24–25 years) in South Africa Nasopharynx | ↑ Streptococcus pneumoniae, ↑ Staphylococcus aureus |
[110] | Hospitalized infants (under 1 year of age) in the USA Nasopharynx | ↑ Haemophilus spp. | |
Rhinovirus-C | [116] | Young children (under 3 years old) in Peru Nasopharynx | ↑ Streptococcus pneumoniae, ↑ Staphylococcus aureus |
[109] | Patients (mean age 24–25 years) in South Africa Nasopharynx | ↑ Streptococcus pneumoniae, ↑ Staphylococcus aureus | |
[110] | Hospitalized infants (under 1 year of age) in the USA Nasopharynx | ↑ Moraxella spp. |
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Elgamal, Z.; Singh, P.; Geraghty, P. The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease. Medicina 2021, 57, 823. https://doi.org/10.3390/medicina57080823
Elgamal Z, Singh P, Geraghty P. The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease. Medicina. 2021; 57(8):823. https://doi.org/10.3390/medicina57080823
Chicago/Turabian StyleElgamal, Ziyad, Pratyush Singh, and Patrick Geraghty. 2021. "The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease" Medicina 57, no. 8: 823. https://doi.org/10.3390/medicina57080823