Isoflurane Potentiation of GABAA Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation
Abstract
:1. Introduction
2. Results
2.1. Isoflurane Modulation of GABA—Elicited Currents
2.2. Direct Activation of GABAA Receptors by Isoflurane
3. Discussion
3.1. Identification of Molecular Targets of Anesthetics
3.2. Contribution of GABAAR Modulation to Memory Suppression
4. Materials and Methods
4.1. Cell Culture and Receptor Expression
4.2. Electrophysiological Recordings
4.3. Solution Preparation and Application
4.4. Data Analysis
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Lor, C.; Perouansky, M.; Pearce, R.A. Isoflurane Potentiation of GABAA Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation. Int. J. Mol. Sci. 2020, 21, 9534. https://doi.org/10.3390/ijms21249534
Lor C, Perouansky M, Pearce RA. Isoflurane Potentiation of GABAA Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation. International Journal of Molecular Sciences. 2020; 21(24):9534. https://doi.org/10.3390/ijms21249534
Chicago/Turabian StyleLor, Chong, Misha Perouansky, and Robert A. Pearce. 2020. "Isoflurane Potentiation of GABAA Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation" International Journal of Molecular Sciences 21, no. 24: 9534. https://doi.org/10.3390/ijms21249534