Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade
Abstract
:1. Introduction
2. Antioxidant Properties and Bioaccessibility of Seaweed Xanthophyll Carotenoids
3. Fucoxanthin and Obesity
3.1. Therapeutic Potential of Fucoxanthin in Obesity
3.2. Mechanisms of the Anti-Obesity Effect of Fucoxanthin
4. Astaxanthin and Obesity
4.1. Therapeutic Potential of Astaxanthin in Obesity
4.2. Mechanisms of the Anti-Obesity Effect of Astaxanthin
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
ABTS | 2,2′-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid |
DPPH | 2,2-Diphenyl-1-picrylhydrazyl |
ABAP | 2,2′-azobis(2-amidopropane) |
ACC | Acetyl-CoA carboxylase |
AMPK | AMP-activated protein kinase |
ASX | Astaxanthin |
BMI | Body mass index |
TNF-α | Tumor necrosis factor α |
C/EBPα | CCAAT Enhancer Binding Protein Alpha |
COX-2 | Cyclooxygenase-2, |
FRAP | Ferric reducing antioxidant capacity |
FXN | Fucoxanthin |
iNOS | Inducible nitric oxide synthase |
mRNA | Messenger RNA |
ORAC | Oxygen radical absorbance capacity |
PPARγ | Peroxisome Proliferator-activated Receptor γ |
SCD1 | Stearoyl-coenzyme A desaturase-1 |
SREBP-1c | Sterol regulatory element-binding protein |
WAT | White adipose tissue |
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s/n | Subject/Model | Effective Dose | Seaweed Specie | Observed Effect | References |
---|---|---|---|---|---|
1 | Male Sprague Dawley Rat | 0.083 and 0.167 mg/kg/bw FXN supplementation in HFD | not mentioned | Plasma and liver triglyceride concentrations were reduced and cholesterol-regulating enzymes such as 3-hydroxy-3-methylglutarylcoenzyme A reductase and acyl-coenzyme A were positively influenced. | [96] |
2 | Obese KK-Ay mice | 0.2% FXN diet | Undaria pinnatifida | The increase in HDL and non-HDL (High-Density Lipoprotein) cholesterol levels; reduction in liver uptake of cholesterol were observed in KK-Ay mice. | [84] |
3 | KK-Ay mice and B6. V-Lepob/J (ob/ob) mice | 0.1 or 0.2% FXN supplemented diet | Undaria pinnatifida | Suppressed body weight, visceral WAT mass, and lowered serum leptin levels. | [97] |
4 | Mice | 150 mg/kg/day | Petalonia binghamiae | PBE (or FXN) exert improving effects on HFD-induced obesity by promoting β-oxidation and reducing lipogenesis. | [98] |
5 | C57BL/6J and KK-Ay mice | 0.2% fucoxanthin FXN | Undaria pinnatifida | FXN regulated mRNA expression of inflammatory adipocytokines, and attenuated both body weight gain and WAT weight in diabetic/obese KK-Ay mice, but did not affect these parameters in lean C57BL/6J mice | [85] |
6 | Obese female volunteers with 100 kg average weight | 2.4 mg/kg/day | Undaria pinnatifida | Increased energy expenditure in the body and resulted in significant weight loss after 16 weeks. | [45] |
7 | Female KK-Ay mice | 2% seaweed lipids containing FXN 16–21 mg/g | Undaria pinnatifida (Wakame), Sargassum horneri (Akamoku), and Cystoseira hakodatensis (Uganomoku) | Significant decrease in liver lipid hydroperoxide levels and abdominal WAT weight. | [20] |
8 | C57BL/6N mice | 0.05% and 0.2% FXN in diet, w/w | Undaria pinnatifida | FXN supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration. | [44] |
9 | C57BL/6J mice | 0.02% dose | Undaria pinnatifida | Ethanol extract on diet-induced-insulin resistance in C57BL/6J mice | [94] |
10 | C57BL/6J mice | 0.05 or 0.2% FXN supplemented diet | Undaria pinnatifida | Regulated plasma and hepatic lipid metabolism; increased fecal lipid excretion. Fecal weight, liver, and triglycerides and cholesterol were not significantly different between 0.05 and 0.2% FX fed mice. | [62] |
11 | 30 male 4-week-old C57BL/6 mice | Oral; 150 mg/kg/day for 70 days | Petalonia binghamiae | Extract (PBE) administration reduced body weight gain, adipose tissue weight, adipose cell size, serum triglyceride levels, and reduced lipid accumulation in the liver in HFD-induced obese mice. | [98] |
12 | 3T3-L1 adipocyte | 10 µM treatment | Petalonia binghamiae | FXN activated the AMPK signaling pathway; increased the phosphorylation of LKB1, AMPK, and ACC; and inhibited the expression of PPARγ, C/EBPα, and SREBP1c in mature 3T3-L1 adipocytes. | [92,98] |
13 | Male Sprague-Dawley rats | 0.2% FXN powder in feed | Undaria pinnatifida | The levels of hepatic lipids cholesterols and triglycerides were reduced significantly, with subsequent increases in the fecal excretions of lipids, cholesterol, and triglycerides in the FXN supplemented group. | [46] |
14 | Sprague-Dawley rats | 5% seaweeds powder supplemented in HFD | Eucheuma cottonii; aulerpa lentillifera, and Sargassum polycystum | All seaweeds significantly reduced body weight gain and plasma lipid peroxidation in HCF diet rats. However, S. polycystum showed the best anti-obesity properties. | [49] |
15 | KK-Ay mice and B6. V-Lepob/J (ob/ob) mice | 0.1 or 0.2% FXN supplemented diet | Undaria pinnatifida | Suppressed body weight, visceral WAT mass, and lowered serum leptin levels. | [97] |
16 | C57BL/6N mice | 0.05 or 0.2% FXN supplemented diet | Undaria pinnatifida | Regulated plasma and hepatic lipid metabolism; increased fecal lipid excretion. Fecal weight, liver, and triglycerides and cholesterol were not significantly different between 0.05 and 0.2% FX fed mice. | [62] |
17 | Human | 6, 12, and 18 mg/day of ASX | Haematococcus pluvialis | 12 and 18 mg/day improved the serum lipid profile in humans (decrease in TG levels observed), 6 and 12 mg/day increased HDL-cholesterol; however, BMI values remained unchanged. | [99] |
18 | Male C57BL/6J mice | HF diet supplemented 0.003, 0.01 and 0.03% of ASTX (by weight) | Hematococcus pluvialis | 0.03% ASX fed group showed significantly lowered triacylglycerol concentrations; increased the hepatic expression of endogenous antioxidant genes. | [100] |
19 | Male apoE knockout (apoE)−/− mic | 0.03% ASX | Haematococcus pluvialis | ASX-rich H. pluvialis extract improves cholesterol and lipid metabolism as well as antioxidant defense mechanisms. | [101] |
20 | Male Swiss albino mice | 6 mg/kg per day in olive oil for 60 days | Haematococcus pluvialis | ASX treatment reduced lipid accumulation and oxidative stress and adipose tissue weight. Also improved insulin sensitivity. | [102] |
21 | Human; overweight and obese young adults | 5 mg and 20 mg soft ASX capsule | not mentioned | Improved lipid metabolism and prevented oxidative stress by stimulating the activity of the antioxidant defense system. | [103] |
22 | Male mus musculus albino mice | 6 mg/kg per day in olive oil for 60 days | Haematococcus pluvialis | ASX improved antioxidant status, restricted weight gain, enhanced insulin sensitivity and restored liver lipid levels. | [104] |
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Ojulari, O.V.; Lee, S.G.; Nam, J.-O. Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade. Int. J. Mol. Sci. 2020, 21, 2502. https://doi.org/10.3390/ijms21072502
Ojulari OV, Lee SG, Nam J-O. Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade. International Journal of Molecular Sciences. 2020; 21(7):2502. https://doi.org/10.3390/ijms21072502
Chicago/Turabian StyleOjulari, Oyindamola Vivian, Seul Gi Lee, and Ju-Ock Nam. 2020. "Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade" International Journal of Molecular Sciences 21, no. 7: 2502. https://doi.org/10.3390/ijms21072502