Photodynamic Diagnosis and Therapy for Peritoneal Carcinomatosis: Emerging Perspectives
Abstract
:Simple Summary
Abstract
1. Introduction
1.1. Peritoneal Carcinomatosis: Origins, Occurrence, Diagnosis and Treatment
1.2. Photodynamic Diagnosis (PDD) and Photodynamic Therapy (PDT)
2. Photodynamic Diagnosis for Peritoneal Carcinomatosis
2.1. Clinical State-of-the-Art
2.1.1. Ovarian Cancer
2.1.2. Gastric Cancer
2.1.3. Colorectal Cancer
2.1.4. Pancreatic Cancer
2.1.5. Other Cancer Types
2.1.6. Predictive Diagnosis with PDD
2.2. PDD for Peritoneal Carcinomatosis: Challenges to Overcome
2.2.1. Tumor Heterogeneity
2.2.2. Increasing Specificity and Selectivity
2.2.3. Light Sources
2.3. Promising Experimental Studies on PDD for Peritoneal Carcinomatosis
2.3.1. Increasing Specificity and Selectivity
2.3.2. Light Sources
3. Photodynamic Therapy for Peritoneal Carcinomatosis
3.1. Clinical State-of-the-Art
3.1.1. Safety and Feasibility Studies
3.1.2. Ovarian Cancer
3.1.3. Gastric/Intestinal Cancer
3.1.4. Primary PCAR
3.1.5. Adverse Events
3.1.6. Ongoing Trials
3.2. PDT for Peritoneal Carcinomatosis: Challenges to Overcome
3.2.1. Tumor Heterogeneity
3.2.2. Selectivity and Efficacy of PDT
3.2.3. Integration into Clinical Practice
3.2.4. Excitation Sources
3.3. Promising Experimental Studies on PDT for Peritoneal Carcinomatosis
3.3.1. Selectivity and Efficacy of PDT
3.3.2. Integration into Clinical Practice
3.3.3. Light Sources
3.4. Radiotherapy-Activated PDT for PCAR
4. Conclusions and Perspectives
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Photosensitizer | Application | Peak Excitation Wavelengths | Molar Extinction Coefficient (M−1cm−1) | Peak Emission Wavelength | State of Development | Ref. |
---|---|---|---|---|---|---|
Aminolevulinic acid (PpIX) | PDD & PDT | 409 nm 630 nm | 1.2 × 105 (409 nm) 5.0 × 103 (630 nm) | 635 nm | Clinical trials | [21] |
Indocyanine green | PDD | 780 nm | 2.6 × 105 | 835 nm | Clinical trials | [22] |
Porfimer sodium | PDT | 630 nm | 1.2 × 103 | 635 nm | Clinical trials | [21] |
Hypericin | PDD & PDT | 589 nm | 4.5 × 104 | 599 nm | Clinical trials | [21] |
Pyropheophorbide A (Folate-conjugated) | PDD & PDT | 668 nm | 4.5 × 104 | 672 nm | Preclinical | [23] |
Meso-tetrahydroxy-phenylchlorin (Folate-conjugated) | PDD & PDT | 652 nm | 2.9 × 104 | 655 nm | Preclinical | [21] |
Benzoporphyrin derivative (anti-EGFR mAb-conjugated) | PDD & PDT | 692 nm | 3.3 × 104 | 695 nm | Preclinical | [24] |
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Xu, S.; Bulin, A.-L.; Hurbin, A.; Elleaume, H.; Coll, J.-L.; Broekgaarden, M. Photodynamic Diagnosis and Therapy for Peritoneal Carcinomatosis: Emerging Perspectives. Cancers 2020, 12, 2491. https://doi.org/10.3390/cancers12092491
Xu S, Bulin A-L, Hurbin A, Elleaume H, Coll J-L, Broekgaarden M. Photodynamic Diagnosis and Therapy for Peritoneal Carcinomatosis: Emerging Perspectives. Cancers. 2020; 12(9):2491. https://doi.org/10.3390/cancers12092491
Chicago/Turabian StyleXu, Si, Anne-Laure Bulin, Amandine Hurbin, Hélène Elleaume, Jean-Luc Coll, and Mans Broekgaarden. 2020. "Photodynamic Diagnosis and Therapy for Peritoneal Carcinomatosis: Emerging Perspectives" Cancers 12, no. 9: 2491. https://doi.org/10.3390/cancers12092491