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Review

Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

by
Baptiste Barré
,
Laurine Gonnard
,
Amandine Guérinot
* and
Janine Cossy
*
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI Paris, CNRS, PSL Research University 10, rue Vauquelin 75231 Paris CEDEX 05, France
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(6), 1449; https://doi.org/10.3390/molecules23061449
Submission received: 16 May 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 14 June 2018
(This article belongs to the Special Issue Frontiers in Metal-Catalysed Cross-Coupling Reactions for the Synthesis and Functionalisation of Heterocycles)
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Abstract

:
(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented.

Graphical Abstract

1. Introduction

The analysis of druglike chemical space is of outstanding importance in medicinal chemistry. In a recent report, Taylor et al. studied the occurrence of ring frameworks in approved drugs listed in the FDA orange book and established a top 100 of the most frequent ring systems present in small molecule drugs [1]. Although the benzene ring holds the first place in the classification, N-heterocycles are ubiquitous. Among them, pyridine is ranked second, piperidine third, piperazine fourth, imidazole seventh and pyrrolidine eighth. Worthy of note, while azetidine itself is not present in the classification, a bicylic ring system incorporating a β-lactam moiety can be found at position nine (Figure 1).
Among the saturated N-heterocycles, 4-arylpiperidines, 3-arylpiperidines, 3-arylpyrrolidines and 3-arylazetidines are attractive scaffolds in drug discovery, exhibiting a broad range of biological activities [2,3,4,5,6,7,8]. Due to these interesting properties, numerous methods have been developed to access these aryl substituted N-heterocycles, either through ring formation or arylation of cyclic compounds [9,10,11,12,13]. The latter approach could be considered more convergent when molecular diversity is targeted and, particularly, metal-catalyzed cross-couplings involving (pseudo)halogeno-N-heterocycles have emerged as a powerful strategy to generate libraries of arylated N-heterocycles. In this field, tremendous efforts have been made for the arylation of 4-(pseudo)halopiperidines and numerous metal-catalyzed cross-couplings with organometallic reagents have been reported. Thus, Hiyama [14,15] Suzuki [16,17,18,19,20], Kumada-Corriu [21,22,23,24] and Negishi [25,26,27,28,29,30,31,32,33] couplings have been used to synthesize 4-arylpiperidines using nickel, iron and cobalt catalysts [34]. In addition, nickel-catalyzed reductive coupling involving 4-halopiperidines and (hetero)aryl halides have also been described in the literature [35,36,37,38,39]. In contrast, examples of arylation of 3-halopiperidines are scarce. Knochel et al. recently disclosed a cobalt-catalyzed cross-coupling between 3-iodo-N-Boc-piperidine and diarylmanganese reagents to furnish the 3-aryl piperidine in 60% yield [34]. 3-Arylpiperidines could also be formed through nickel catalyzed reductive coupling using aryl bromides [38,39,40]. Similarly, various metal-catalyzed cross-coupling with aryl organometallics [34,41,42,43,44] and metal-catalyzed reductive coupling with aryl halides [38,45] have been used to access 3-arylpyrrolidines and the arylation of 3-haloazetidines has received increasing attention over the past few years. Most of the examples involve nickel-catalyzed Suzuki cross-coupling with aryl boronic acids [46] but 3-arylated azetidines could be obtained from 3-iodoazetidines using iron-catalyzed coupling with aryl Grignard reagents [23,47]. Reductive cross-couplings between 3-iodoazetidine and aryl bromides were also employed to access 3-aryl- azetidines [33,44,48,49,50] (Scheme 1).
Despite the variety of reactions existing for the arylation of saturated N-heterocycles from halogeno precursors, a unified method allowing the arylation of 4- and 3-halopiperidines, 3-halo-pyrrolidines and 3-haloazetidines was still needed. During the course of our studies toward the development of sustainable methods to access biologically relevant scaffolds, cobalt-catalyzed arylation of saturated halogeno N-heterocycles was investigated [51,52,53]. Herein, we report an overview of our work concerning the arylation of 4-iodopiperidines and 3-iodopiperidines, -pyrrolidines and -azetidines. The reactions are efficient, versatile, chemoselective and involve a non-expensive catalytic system (Scheme 2) [54,55].

2. Arylation of 4-Halopiperidines

The reactivity of 4-halopiperidines with aryl Grignard reagents was evaluated to access 4-aryl- piperidines. When N-Boc-4-iodo piperidine 1a was treated with phenylmagnesium bromide in the absence of any metal catalyst, no conversion of the iodide was observed and the starting material was fully recovered (Table 1, entry 1). Pleasingly, when Co(acac)3 (5 mol %) was introduced in association with N,N-tetramethylethylenediamine (TMEDA) (6 mol %) as a ligand, the iodo piperidine 1a was partially transformed to the coupling product 2a (1a/2a = 79:21) (Table 1, entry 2). The replacement of TMEDA by (R,R)-tetramethylcyclohexanediamine (TMCD) increased the conversion of 1a (1a/2a = 87:13) (Table 1, entry 3). Finally, changing Co(acac)3 for CoCl2 proved beneficial, allowing a full conversion of 1a into the 4-phenylpiperidine, which could be isolated with a good 81% yield (Table 1, entry 4).
With these optimized conditions in hand, the influence of the N-protecting group on the cross-coupling outcome was investigated. A N-tosyl group was tolerated but the corresponding arylated N-tosyl piperidine 2b was isolated with an inferior yield compared to the N-Boc piperidine 2a (69% versus 81%) and two equivalents of the Grignard reagent were required to ensure full conversion of the iodide (Table 1, entry 5). With a N-benzyl protected iodopiperidine, the coupling proved more difficult, probably due to the coordination of the nitrogen atom to the metal catalyst, and the use of 50 mol % of TMCD was needed to obtain a satisfactory yield in 2c (66%) (Table 1, entry 6). The N-Boc 4-bromopiperidine 1b was less reactive than its iodide counterpart and an increased amount of the Grignard reagent had to be added to reach full conversion (Table 1, entry 7). In light of these results, the best conditions to obtain 4-phenylpiperidine involve the use of N-Boc 4-iodopiperidine (1 equiv), CoCl2 (5 mol %), TMCD (6 mol %) and phenylmagnesium bromide (1.2 equiv) in THF. No syringe pump was needed, the dropwise addition of the Grignard reagent was performed at 0 °C and stirring was continued for 3 h at room temperature. With these conditions in hand, the scope of the arylation was investigated using N-Boc iodopiperidines.
A range of aryl magnesium bromides was used in the cross-coupling with N-Boc 4-iodo- piperidine 1a. The electronic properties of the substituents present on the phenyl ring had little influence on the reaction as both electron-donating (p-Me, p-NMe2) and electron-withdrawing (m-OMe, p-F, p-CF3) groups were well tolerated. In some cases, the Grignard reagent was prepared as an LiCl complex according to a method reported by Knochel et al. using a catalytic amount of DIBAL-H and a stoichiometric amount of LiCl [56]. These Grignard reagents exhibited similar reactivity to the classical ones under the coupling conditions. The coupling was not sensitive to steric hindrance and o-tolylmagnesium bromide reacted smoothly with iodopiperidine 1a to deliver 2i in a good 88% yield. The formation of the 4-arylpiperidine 2j possessing a carbonate substituent on the phenyl ring highlighted the chemoselectivity of the cross-coupling. However, in the presence of a cyano group, the reaction turned sluggish leading to a poor conversion of 1a (1a/2k = 70:30) that did not allow the isolation of the corresponding 4-arylpiperidine 2k. A poisoning of the catalyst by coordination of the nitrile group could account for this limitation. Pleasingly, 3-pyridylmagnesium bromide was efficiently coupled to iodopiperidine 1a, a decrease in temperature being the key to achieve a high yield in 2l (96%). Despite its Lewis basicity, the nitrogen atom present on the pyridine moiety does not seem to interfere with the cobalt catalyst (Scheme 3).

3. Arylation of 3-Halopiperidines

As previously mentioned, examples of cross-coupling involving 3-halopiperidines are scarce in the literature. When the previously developed conditions [CoCl2 (5 mol %), TMCD (6 mol %), 0 °C to rt] were used to perform the coupling between N-Boc 3-iodopiperidine 3a and phenylmagnesium bromide, a full conversion of 3a was observed, but the desired arylated compound was formed together with several non-identified side products. Lowering the temperature to -10 °C was crucial to allow a selective reaction to occur and, under these conditions, piperidine 4a was isolated in a good yield (88%). A variety of aryl Grignard reagents differing from the nature of their substituents on the phenyl ring were used with iodopiperidine 3a, delivering the corresponding 3-arylpiperidine with good to excellent yields (81–94%). The introduction of a pyridyl group at the C3 position was possible, but a moderate yield in the coupling product 4h was obtained (47%). Increasing the amount of the TMCD ligand (50 mol %) only slightly improved the result (57%) (Scheme 4).
The cross-coupling was then used at the key step in a concise synthesis of the antipsychotic (±)-preclamol [57,58,59]. Treatment of the N-Boc 3-iodopiperidine 3a with m-methoxyphenylmagnesium bromide in the presence of the CoCl2/TMCD catalytic system afforded the 3-arylated piperidine 4i (88%). After the amine deprotection and reductive amination, the N-propylpiperidine was obtained. Finally, the cleavage of the methoxyether under acidic conditions (HBr) delivered (±)-preclamol (33% overall yield over four steps) (Scheme 5).
In the literature, the formation of radical species during cobalt-catalyzed cross-coupling has been observed on several occasions [60,61,62,63]. To determine if radical intermediates were present during the arylation of 3-iodopiperidines under our optimized conditions, two radical clocks were synthesized. When the disubstituted 3-iodopiperidine 5a possessing an O-allyl group at C2 was treated with phenylmagnesium bromide in the presence of CoCl2 and TMCD, the bicyclic compound 6a was formed exclusively (81%, dr = 80:20) (Scheme 6). This product results from a 5-exo-trig cyclization prior to the cross-coupling. On the contrary, iodopiperidine 5b, possessing an additional carbon atom on the C2 pendant chain, was transformed in the 3-phenylpiperidine 6b resulting from a direct cross-coupling at C3 (Scheme 6). These results could suggest that transient radical intermediates were formed during the coupling. The evolution of these species (cyclization then cross-coupling versus direct cross-coupling) would depend on the kinetic of the cyclization, the 5-exo-trig cyclization being approximately 1000 times faster than the 6-exo-trig cyclization.

4. Arylation of 3-Iodopyrrolidines

The cross-coupling was then successfully extended to the arylation of 3-iodopyrrolidines. A library of 3-arylpyrrolidines was prepared using a similar catalytic system to the one used for the arylation of iodopiperidines [CoCl2 (5 mol %), TMCD (6 mol %)]. Whatever the nature of the aryl Grignard reagent, the 3-arylpyrrolidines were obtained with good to excellent yield (74%–93%) (Scheme 7) [56].
When iodopyrrolidine 9a bearing an O-allyl chain at C4 was involved in the cross-coupling, the bicyclic compound 10a was obtained as the sole product with a good yield of 80% (dr = 80:20) (Scheme 8). The existence of this 5-exo-trig cyclization prior to the cross-coupling supports the hypothesis of radical intermediate formation during the reaction.

5. Arylation of 3-Iodoazetidines

Pleasingly, the same catalytic system proved also efficient for the arylation of N-Boc 3-iodoazetidine 11a. A broad range of aryl groups were efficiently introduced at the C3 position of the azetidine. Interestingly, heteroaryl Grignard reagents incorporating either a pyridine or a thiophene moiety were well tolerated, leading to the corresponding azetidines 12i and 12j with excellent yields of ca. 90% (Scheme 9) [56].
The reactivity of 2,3-disubstituted azetidines was then investigated and a mixture of cis- and trans-iodoazetidines 13a (cis-13a/trans-13a = 75:25) was treated with phenylmagnesium bromide in the presence of CoCl2 and TMCD. The desired arylated product was isolated in 93% yield as a mixture of diastereomers, the trans diastereomer being the major product (cis-14a/trans-14a = 13:87) (Scheme 10). The inversion of the cis/trans ratio could be due to the formation of a radical intermediate at the C3 position that allowed a diastereoconvergent coupling to occur. However, an epimerization of the organocobalt species resulting from the oxidative addition step could not be excluded.

6. Mechanistic Hypothesis

Based on literature reports [61] and on our observations, the mechanism depicted in Scheme 11 can be proposed. At first, a reduction of the Co(II) complex into the active species would be performed by the Grignard reagent to deliver the active catalyst A [PhxCo(n) (n = 0, I)], which oxidation state remains uncertain. A Single Electron Transfer (SET) from this complex to the iodo N-heterocycle would deliver a Co(n+1) complex together with the radical intermediate B. A subsequent combination of the Co(n+1) complex with radical B would led to an organocobalt (n+2) intermediate that would give the product after reductive elimination. A transmetalation between complex D and PhMgBr would finally regenerate the active catalyst.

7. Conclusions

In conclusion, an efficient and simple cobalt-catalyzed arylation of saturated iodo-N-heterocycles with Grignard reagents was developed. A diversity of N-arylated heterocycles was thus prepared from the iodide precursors using a unique catalytic system composed of CoCl2 and TMCD. The process is non-expensive, versatile, chemoselective and diastereoselective. The reaction has been used as the key step in a short synthesis of (±)-preclamol. In the future, this cross-coupling could be of high synthetic value to access biologicaly active molecules embedding saturated N-heterocycles.

Author Contributions

All the authors contributed to this overview.

Acknowledgments

We thank NovAliX (CIFRE to B.B.) and MRNET (grant to L.G.) for financial support.

Conflicts of Interest

The authors declare no conflict of interest.

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Molecules 23 01449 g001 550
Figure 1. Top 10 of the most frequent rings in drugs.
Figure 1. Top 10 of the most frequent rings in drugs.
Molecules 23 01449 g001
Molecules 23 01449 sch001 550
Scheme 1. Metal-catalyzed cross-coupling reactions between halogeno N-heterocycles and (hetero)aromatic organometallic reagents.
Scheme 1. Metal-catalyzed cross-coupling reactions between halogeno N-heterocycles and (hetero)aromatic organometallic reagents.
Molecules 23 01449 sch001
Molecules 23 01449 sch002 550
Scheme 2. Cobalt-catalyzed cross-coupling reactions between halogeno N-heterocycles and (hetero)aromatic Grignard reagents.
Scheme 2. Cobalt-catalyzed cross-coupling reactions between halogeno N-heterocycles and (hetero)aromatic Grignard reagents.
Molecules 23 01449 sch002
Molecules 23 01449 sch003 550
Scheme 3. Scope of the cross-coupling involving N-Boc-4-iodopiperidine 1a and various aryl Grignard reagents. [a] Grignard reagents prepared as ArMgBr.LiCl were used [56].
Scheme 3. Scope of the cross-coupling involving N-Boc-4-iodopiperidine 1a and various aryl Grignard reagents. [a] Grignard reagents prepared as ArMgBr.LiCl were used [56].
Molecules 23 01449 sch003
Molecules 23 01449 sch004 550
Scheme 4. Scope of the cross-coupling involving N-Boc-3-iodopiperidine 3a and various aryl Grignard reagents. [a] Grignard reagents prepared as ArMgBr.LiCl were used [56]. [b] Using 50 mol % of TMCD.
Scheme 4. Scope of the cross-coupling involving N-Boc-3-iodopiperidine 3a and various aryl Grignard reagents. [a] Grignard reagents prepared as ArMgBr.LiCl were used [56]. [b] Using 50 mol % of TMCD.
Molecules 23 01449 sch004
Molecules 23 01449 sch005 550
Scheme 5. Synthesis of (±)-preclamol.
Scheme 5. Synthesis of (±)-preclamol.
Molecules 23 01449 sch005
Molecules 23 01449 sch006 550
Scheme 6. Cross-coupling reactions involving radical clocks 5a and 5b.
Scheme 6. Cross-coupling reactions involving radical clocks 5a and 5b.
Molecules 23 01449 sch006
Molecules 23 01449 sch007 550
Scheme 7. Cross-coupling of 3-iodopyrrolidine 7a with various aryl Grignard reagents. [a] Grignard reagents prepared as ArMgBr.LiCl were used [56].
Scheme 7. Cross-coupling of 3-iodopyrrolidine 7a with various aryl Grignard reagents. [a] Grignard reagents prepared as ArMgBr.LiCl were used [56].
Molecules 23 01449 sch007
Molecules 23 01449 sch008 550
Scheme 8. Cross-coupling involving radical clock 9a.
Scheme 8. Cross-coupling involving radical clock 9a.
Molecules 23 01449 sch008
Molecules 23 01449 sch009 550
Scheme 9. Cross-coupling of 3-iodoazetidine 11a with various aryl Grignard reagents. [a] Grignard reagents prepared as ArMgBr.LiCl were used [56].
Scheme 9. Cross-coupling of 3-iodoazetidine 11a with various aryl Grignard reagents. [a] Grignard reagents prepared as ArMgBr.LiCl were used [56].
Molecules 23 01449 sch009
Molecules 23 01449 sch010 550
Scheme 10. Diastereoselectivity of the cross-coupling reaction.
Scheme 10. Diastereoselectivity of the cross-coupling reaction.
Molecules 23 01449 sch010
Molecules 23 01449 sch011 550
Scheme 11. Hypothetical mechanism.
Scheme 11. Hypothetical mechanism.
Molecules 23 01449 sch011
Table
Table 1. Cobalt-catalyzed cross-coupling between 4-halopiperidines and phenylmagnesium bromide.
Table 1. Cobalt-catalyzed cross-coupling between 4-halopiperidines and phenylmagnesium bromide.
Molecules 23 01449 i001
Entry1 (X, PG)[Co] L [a] 1/2 [b]2 (yield) [c]
11a (I, Boc)--1a/2a = 100:0-
21a (I, Boc)Co(acac)3TMEDA1a/2a = 21:79n. d.
31a (I, Boc)Co(acac)3TMCD1a/2a = 13:87n. d.
41a (I, Boc)CoCl2TMCD1a/2a = 0:1002a (81%)
5[d]1b (I, Ts)CoCl2TMCD1b/2b = 0:1002b (69%)
6 [d], [e]1c (I, Bn)CoCl2TMCD1c/2c = 0:1002c (66%)
7 [d]1d (Br, Boc)CoCl2TMCD1d/2a = 0:1002a (83%)
[a] TMEDA = N,N-tetramethylethylenediamine, TMCD = (R,R)-tetramethylcyclohexanediamine. [b] The ratio was determined using the crude 1H-NMR spectrum. [c] Isolated yield. [d] Two equivalents of PhMgBr were added. [e] 50 mol % of TMCD were added.

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Barré, B.; Gonnard, L.; Guérinot, A.; Cossy, J. Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents. Molecules 2018, 23, 1449. https://doi.org/10.3390/molecules23061449

AMA Style

Barré B, Gonnard L, Guérinot A, Cossy J. Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents. Molecules. 2018; 23(6):1449. https://doi.org/10.3390/molecules23061449

Chicago/Turabian Style

Barré, Baptiste, Laurine Gonnard, Amandine Guérinot, and Janine Cossy. 2018. "Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents" Molecules 23, no. 6: 1449. https://doi.org/10.3390/molecules23061449

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