Association between parental unhealthy behaviors and offspring’s cardiovascular health status: Results from a cross-sectional analysis of parent–offspring pairs in China
Qi Ma1 
Jieyu Liu1 
Yu Wu2 Mengjie Cui1 
Manman Chen1 Tao Ma1 Xinxin Wang3 
Di Gao1 
Yanhui Li1 
Li Chen1 
Ying Ma1 Yi Zhang1 
Yanhui Dong1 
Yi Xing1* 
Jun Ma1
- 1Institute of Child and Adolescent Health, School of Public Health, Peking University; National Health Commission Key Laboratory of Reproductive Health, Beijing, China
- 2School of Population Medicine and Public Health, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China
- 3School of Public Health and Management, Ningxia Medical University and Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China
Background: Cardiovascular health (CVH) in children and adolescents, which might be largely influenced by parental behaviors, may affect the incidence of cardiovascular diseases in adulthood. However, few studies have been conducted to explore the associations between parental behaviors and CVH status of offspring in China.
Methods: Data were obtained from a cross-sectional survey conducted in Chinese children and adolescents aged 7–18 years old, with a total of 10,043 parent–offspring pairs included. Parental behaviors included moderate to vigorous physical activity (MVPA), dietary behaviors, and weight status. The CVH status of offspring was consulted by The American Heart Association, including seven factors. The associations between parental behaviors and CVH status of offspring were evaluated by multilevel logistic regression. Stratified analyses were conducted to explore the potential modifying influence of sociodemographic factors.
Results: Most of the offspring had five ideal CVH factors; only 21.04% had six to seven ideal CVH factors. Parental unhealthy behaviors were associated with high odds of nonideal CVH status of offspring. Parental overweight/obesity, insufficient MVPA, and unhealthy dietary behaviors could increase the odds of owning one to three ideal CVH factors in offspring, with corresponding odds ratios (ORs) (95% confidence interval) of 1.61 (1.32–1.96), 1.31 (1.10–1.56), and 2.05 (1.43–2.94), respectively. There was a dose–response relationship between parental single unhealthy behavior and the odds of nonideal CVH status in offspring (P-trend < 0.001). Offspring with overweight parents had ORs of 1.25 for nonideal CVH status, compared to offspring with normal-weight parents. Among offspring who had the same number of ideal CVH factors, the cumulative association between unhealthy behaviors of parents and offspring’s nonideal CVH status increased if parents had more unhealthy behaviors (P-trend < 0.001).
Conclusions: Parental overweight/obesity, insufficient MVPA, and unhealthy dietary behaviors were strongly associated with CVH status in offspring. With a cumulative association, more unhealthy parental behaviors were associated with higher odds of offspring’s nonideal CVH status, suggesting that targeting parental behaviors might facilitate attainment of improving CVH status of children and adolescents.
Introduction
Cardiovascular diseases (CVDs) are the leading cause of death around the world (1). In China, more than two in five deaths were attributed to CVDs, accounting for 45.50% and 43.16% of all deaths in rural and urban areas in 2016, which were higher than the death rate due to cancer or other diseases (2). Making efforts to improve cardiovascular health (CVH), the American Heart Association (AHA) introduced a concept of ideal CVH status, including the simultaneous presence of nonsmoking, as well as the ideal level of body mass index (BMI), physical activity, dietary behaviors, total cholesterol (TC), blood pressure (BP), and fasting plasma glucose (FPG) (3).
The ideal CVH construct appears to be a valid measure for predicting the long-term risk of major adverse cardiovascular events (4, 5). Childhood CVH status was a strong predictor for the incidence of adulthood CVDs (6). A cohort study conducted on young Finns showed that increased ideal CVH factors in children were related to lower risks of hypertension, metabolic syndrome, and carotid artery intima-media thickness (7). In order to achieve primary prevention of adulthood CVDs, substantial work must be done to improve the ideal CVH status in children and adolescents.
However, the prevalence of ideal CVH status in children and adolescents had a similar devastating trend in different countries (8, 9). Although most children and adolescents were born with ideal CVH status, their unhealthy dietary behaviors, physical inactivity, and tobacco smoking they developed gradually would largely influence their CVH status (10). It is well known that parental behaviors are crucial to developing children and adolescents’ behaviors. Previous studies had shown that parents’ diet quality and energy intake, physical activities, and the duration of screen activities were associated with those behaviors of their offspring (11, 12). In addition, the weight status between two generations was correlated according to gene and environmental factors (13, 14). Parental behaviors, therefore, may be greatly associated with the CVH status in children and adolescents.
In the Framingham Heart Study, parental CVH including BMI and nonsmoking status was positively associated with offspring’s CVH status (15). Worse maternal BMI at gestation was significantly associated with worse offspring’s CVH status in early adolescence (16). However, since multiple parental factors are reciprocally interacting, few studies explored the associations between the combined behaviors of parents including physical activity, dietary behaviors, and weight status, with the CVH status in Chinese children and adolescents. We hypothesize that parental unhealthy behaviors might increase the likelihoods of offspring’s nonideal CVH status, and the odds may continue to increase when parents with more unhealthy behaviors increase. To fill these knowledge gaps and improve the grim situation about CVDs in China, based on large and nationally representative data, we aim to explore the associations between parental behaviors and offspring’s CVH status.
Materials and methods
Study design and participants chosen
This is a reanalysis from a previous database, which was collected from a national cross-sectional study from seven Chinese provinces in 2013. More detailed information about this study was presented previously (17). Briefly, we used multistage cluster random sampling to choose participants in seven provinces including Liaoning, Tianjin, Ningxia, Shanghai, Chongqing, Hunan, and Guangdong, which include four differently economic and geographic regions of the mainland of China. A developed and an underdevelopment city were selected in each province at the beginning. Then, 12–16 schools were randomly selected in these cities. Two classes in each grade from each school were randomly chosen subsequently, and their parents were also invited to engage in this survey. A total of 65,347 children and adolescents were included in the study. We selected 15,735 children and adolescents aged 7–18 years old randomly for blood sample examination; those who did not live with their parents or those with missing data on anthropometric measurement, parental questionnaires, and dietary behaviors were excluded. A total of 10,043 parent–offspring pairs were remained in the final analysis (Figure 1).
Figure 1. Selection process of the participants. CVH, cardiovascular health
All survey sites used the same protocol during the implementation process, and all processes of randomization were performed by a staff who was not involved in the survey. This study was approved by the Medical Ethical Committee of Peking University (IRB No. 00001052-12072). All included students and their parents signed the written informed consents.
Data collection in questionnaire
The childhood questionnaire was used to collect information about sex, age, residence area, inhabiting information, smoking, moderate to vigorous physical activity (MVPA), and dietary behaviors. The parental questionnaire was distributed to collect information including the primary respondent of this questionnaire, offspring’s birth weight, single-child status, breastfeeding status, parental self-reported height and weight, highest educational attainment, MVPA, dietary behaviors, and family history of chronic diseases. For birth weight classification, low birth weight and high birth weight were defined as weight <2,500 and ≥4,000 g at delivery, respectively (18). All other information collected in the questionnaire is presented in Supplementary Tables S1, S2.
The frequency (days) and amount (serving per day) were investigated for dietary behaviors, including the total consumption of vegetables, fruits, sugar-sweetened beverages (SSBs), and meat over the past 7 days. One serving of vegetables/fruits was defined as the size of an ordinary adult’s closed fist with roughly 200 g (19); one serving of SSBs was determined as a canned beverage (approximately 250 ml), including orange juice, Nutrition Express, Red Bull, Coca-Cola, and Sprite (20); one portion of meat equaled the size of an adult’s palm (approximately 100 g) (21). We calculated the daily dietary intake as (days of consumption × servings in those days)/7. In addition, the frequency (times) over the past 7 days was investigated for fried foods. As set in questionnaires, fried food consumption referred to fried chicken, deep-fried dough sticks, and other common fried foods.
The self-administered child questionnaires were delivered to students (except grades 1–3) in a class meeting by the trained school teacher. Child questionnaires of children grades 1–3 and parental questionnaires were filled by students’ fathers or mothers. Trained project members provided appropriate guidance and interpreted all the questions as effectively as possible. Three percent of the questionnaires were rechecked within 1 week for the same participants.
Anthropometric measurements
Anthropometric measurements were conducted to measure the height, weight, and BP of children by trained investigators in schools, according to the principles described in the Chinese Students’ Physical Fitness and Health Survey Report 2010 (22). Children were asked to stand straight in light clothing and without shoes. Height was measured using the portable stadiometer with 0.1 cm precision, and weight was measured to the nearest 0.1 kg by a Lever-type might scale. BP was measured in the right arm by a Riva-Rocci sphygmomanometer. Every indicator was measured twice, and the average of the two measurements was used for final analyses. BMI was calculated as the weight (kg) divided by the square of the height (m2).
Blood sample collection and detection
After overnight fasting for 8–12 h, 5 ml venous blood samples were collected for each child or adolescent into Ethylene Diamine Tetraacetic Acid (EDTA) vacuum tubes. Children were asked to rest for at least 10 min before blood sample collection. Blood specimens were transported in a chilled insulated container immediately, centrifuged at 3,000 rpm for 10 min, and then frozen at −80 °C before transported in dry ice to the laboratory in Beijing, where the samples were stored at −80 °C before laboratory detection. Blood tests were performed by an autoanalyzer (Hitachi 7080, Japan). FPG and TC were tested using the glucose oxidase method, enzymatic method, and clearance method. All biochemical analyses on blood were carried out at a biomedical analyses company, which is accredited by Peking University (17).
Definition of ideal CVH of offspring
CVH status of offspring included smoking status, BMI, MVPA, dietary behaviors, BP, FPG, and TC. According to Chinese standards for overweight/obesity (23) and BP (24), The Chinese Dietary Guideline (2016) (25), and AHA (3), we defined the ideal CVH factors as follows (Supplementary Table S3). Children and adolescents meeting 6–7 ideal CVH factors were defined as having ideal CVH status (26), and others were defined as having nonideal CVH status. Participants of nonideal CVH status were divided into three groups according to the numbers of ideal CVH factors they had: 1–3 ideal CVH factors, 4 ideal CVH factors, and 5 ideal CVH factors.
Definition of unhealthy behaviors of parents
Unhealthy behaviors for parents included unhealthy dietary behaviors, insufficient MVPA, and overweight/obesity defined by BMI. All the information about behaviors represented one side of the parents who filled the questionnaire. Parental unhealthy dietary behaviors was determined as <4 healthy dietary factors (the factors was the same to children); insufficient MVPA referred to <150 min/week according to Physical Activity Guidelines for the Chinese Population (2021) (27) and AHA (3); overweight was defined as BMI ≥ 24 and BMI < 28 kg/m2, and obesity was defined as BMI ≥ 28 kg/m2 according to the criteria established by the Working Group on Obesity in China (28). The combined unhealthy behaviors of parents were defined by summing the number of single unhealthy behavior.
Statistical analysis
Descriptive analyses were used to present the basic information of the offspring and parents. Differences by sex were examined using Student’s t-test for continuous variables and Pearson’s χ2 test for categorical variables.
We used a multilevel logistic regression model to eliminate the effects of province-cluster confounders, with provinces set as a random factor in the model. All the outcomes were treated as disordered, not satisfying the test of parallel lines. To explore the association between different unhealthy behaviors of parents and nonideal CVH status of offspring, parental single behavior was examined as two levels (healthy and unhealthy) and the CVH status of offspring was examined as a multiple-category outcome (had 1–3, 4, 5, and 6–7 ideal CVH factors), using pairwise regression. To assess the dose–response association between single unhealthy behavior of parents and offspring’s nonideal CVH status, we examined the single unhealthy behavior of parents as multiple-category outcomes and CVH status of offspring as two variable categories (ideal CVH status and nonideal status, respectively). We also derived a score of parental combined unhealthy behaviors by summing the number of single unhealthy behavior and evaluated the cumulative association between parental combined unhealthy behaviors and offspring’s nonideal CVH status. To assess the influence of sociodemographic factors on the associations between parental unhealthy behaviors and offspring’s CVH status, stratified analyses were additionally conducted. P for trend values were calculated by including the median of each category of single/combined unhealthy behavior of parents as a continuous variable in the model; the interactions between parental unhealthy behaviors and sociodemographic factors were examined using the likelihood ratio test, with a comparison of the log likelihood of the two models with and without the interaction terms. All the models were adjusted for confounders including provinces, family history of chronic diseases, family monthly income, offspring’s age, sex, residence area, birth weight, single-child status, breastfeeding, and parental highest educational attainment. Odds ratio (ORs) and 95% confidence interval (95% CI) were calculated and represented.
The number of each missing variable was approximately 30–884, less than 9% of the total participants (Supplementary Table S4). We used linear interpolation and median to refill the missing data of continuous and categorical variables via the section of Replace Missing Values in SPSS 25.0. To overcome potential limitations, two separate sensitivity analyses were also conducted: (1) all the incomplete data were excluded to evaluate the bias that the refilling method may have; (2) participants with parental BMI < 18.5 kg/m2 [which was defined as thinness (28)] was excluded.
All analyses were performed using IBM SPSS Statistics software (version 25.0, SPSS, IBM, Armonk, NY, United States). A two-sided P-value <0.05 was considered statistically significant.
Result
Baseline characteristics
Table 1 shows the basic characteristics of 10,043 parent–offspring pairs included in the present study. Offspring were 11.22 years old on average, and 44.69% of them were boys. Most of them had five ideal CVH factors, and only 21.04% had six to seven ideal CVH factors. Among all the CVH factors, healthy dietary behaviors accounted for the lowest proportion (9.06%), while nonsmoking status accounted for the highest proportion (98.91%), which was more evident in girls (P < 0.001). Of their parents, more than 50% had the educational attainment of senior high school or above, 47.60% of them had two unhealthy behaviors and only 3.46% had completely combined healthy behaviors.
Table 1. Descriptive characteristics of the study population stratified by sex.
Epidemiology of single behavior of parents and CVH status of offspring
With the increase of parents’ BMI, the decrease of MVPA time, and the number of healthy dietary factors, the percentages of offspring with one to three and four ideal CVH factors increased, and the percentages of six to seven ideal CVH factors decreased (Figure 2 and Supplementary Table S5).
Figure 2. Distribution of participants in different CVH status according to parental behaviors: (A) parental BMI, (B) MVPA, and (C) number of healthy dietary factors. CVH, cardiovascular health; BMI, body mass index; MVPA, moderate to vigorous physical activity.
Association between single unhealthy behavior of parents and offspring’s nonideal CVH status
Table 2 presents the associations between single unhealthy behavior of parents and offspring’s nonideal CVH status. Parental overweight/obesity, insufficient MVPA, and unhealthy dietary behaviors were associated with higher odds of offspring’s nonideal CVH status. Parental overweight/obesity, insufficient MVPA, and unhealthy dietary behaviors could increase the odds of owning one to three ideal CVH factors in offspring, with corresponding ORs (95% CI) of 1.61 (1.32–1.96), 1.31 (1.10–1.56), and 2.05 (1.43–2.94).
Table 2. Association between single unhealthy behavior of parents and offspring’s different groups of nonideal CVH status.
Figure 3 presents a dose–response relationship between single unhealthy behavior of parents and the odds of nonideal CVH status of offspring (all the P-trend < 0.001). Offspring with overweight parents had 25% higher odds (OR = 1.25, 95% CI = 1.10–1.43) for nonideal CVH status compared to offspring whose parents had a normal weight. Parental unhealthy dietary behaviors could increase the odds of offspring’s nonideal CVH status by 52% (OR = 1.52, 95%CI = 1.28–1.8) and 65% (OR = 1.65, 95%CI = 1.03–2.65).
Figure 3. Association between different levels of single behavior of parents and offspring’s nonideal CVH status. Error bar was 95% CI. Multilevel logistic regression was used, and CVH status was defined as nonideal status or ideal CVH status. Data adjusted for provinces, resident area, family history of chronic diseases, family monthly income, offspring’s sex, age, birth weight, single-child status, breast feeding status, and parental highest education attainment. CVH, cardiovascular health; BMI, body mass index; MVPA, moderate to vigorous physical activity; OR, odds ratio; CI, confidence interval.
Association between combined unhealthy behaviors of parents and offspring’s nonideal CVH status
The ORs in different groups of offspring’s nonideal CVH status stratified by the number of parental unhealthy behaviors are presented in Figure 4 and Supplementary Table S6. The odds of nonideal CVH status in offspring with parents who had combined unhealthy behaviors were higher than those whose parents had completely healthy behaviors. Among offspring in the same group of nonideal CVH status, the odds of nonideal CVH status in offspring would increase if the number of parental unhealthy behaviors increased (all the P-trend < 0.001). For example, compared to offspring with parents who had completely healthy behaviors, offspring with parents who had three, two, and one unhealthy behavior had ORs (95% CI) of 3.13 (2.16–4.53), 2.20 (1.59–3.05), and 1.65 (1.19–2.29), respectively, for owning four ideal CVH factors.
Figure 4. Association between combined unhealthy behaviors of parents and offspring's different groups of nonideal CVH status: (A) 1-3 ideal CVH factors, (B) 4 ideal CVH factors, (C) 5 ideal CVH factors. Error bar was 95% CI. The combined behaviors of parents were examined as riable (vs. ideal CVH status). Data adjusted for provinces, resident area, family history of chronic diseases, family monthly incng's sex, age, birth weight, single-child status, breast feeding status, and parental highest education attainment. CVH, cardiovascular health.
Notably, the associations between parental combined unhealthy behaviors and offspring’s nonideal CVH status did not change stratified by sociodemographic factors (Supplementary Table S7).
Sensitivity analysis
Associations between parental unhealthy behaviors and offspring’s nonideal CVH status were robust in all sensitivity analyses, including the following: (1) all the incomplete data were excluded (Supplementary Tables S8–S10); (2) participants with parental BMI < 18.5 kg/m2 were excluded (Supplementary Tables S11–S13).
Discussion
To our knowledge, parental unhealthy behaviors play a crucial role in the offspring’s CVH status in China. Parental overweight/obesity, insufficient MVPA, and unhealthy dietary behaviors were independently strongly associated with nonideal CVH status of offspring, with dose–response associations presented in all behaviors. We also found that the odds of nonideal CVH status of offspring continued to increase as the number of parental unhealthy behaviors increased. Our study emphasized the importance of family-focused community-based prevention programs, proposing that parental behaviors should receive more attention in childhood obesity prevention policies.
In the present study, considering parental behaviors as part of factors of CVH, both single and combined unhealthy behaviors of parents were associated with nonideal CVH status in offspring. One previous study indicated that worse maternal CVH status (included five factors excepted dietary behaviors and MVPA) at gestation was significantly associated with offspring’s worse CVH status in early adolescence (16), and a strong correlation between CVH factors of parents and their offspring was also found when they were at similar ages (15). In the present study, we extended the contents of offspring’s CVH status, and only three kinds of behaviors (overweight/obesity, MVPA, and dietary behaviors) for parental CVH status were selected. Thus, the present study paid more attention on the associations between modifiable behaviors of parents and offspring’s CVH status. Muchira et al. analyzed the association between parental CVH factors and time to onset of CVDs in the offspring and found that offspring would have a longer CVD-free survival if their parents had ideal CVH status (26). Considering one’s ideal CVH status could predict his risk of major CVDs in the future and affect the CVH status of his offspring (4, 5), our study may provide new evidence from parental CVH status to offspring’s future CVDs. However, we did not detect significant differences in associations between parental combined unhealthy behaviors and offspring’s CVH status when stratified by sociodemographic characteristics, and more research studies are urgently needed to verify our conclusions.
The close relationships of multiple lifestyle behaviors between two generations are the potential explanation of the findings. It was well acknowledged that the diet quality and energy intake of parents and their offspring were closely associated in the family (11), same as the pattern of physical activities (12). In addition, parental BMI was a predictor for offspring BMI, exactly as the genetic and environmental factors explicated (13, 29, 30). Family habits contribute the most in modeling children’s lifestyle behaviors as they represent an important moment of parent–child interaction (31), which could also explain the dose–response/cumulative association between single/combined unhealthy behaviors of parents and nonideal CVH status of offspring. In detail, mothers, who were preoccupied with their own weight and eating habit, reported higher levels of encouraging their daughters to lose weight thus leading to daughters’ restrained eating habits (32). Parental behaviors may have a broad and long-term influence on offspring’s CVH status (33); the underlying potential mechanism might be attributed to the following reasons. Offspring loaded heavily on fried foods, SSBs, and refined grain had increased risks of impaired glucose tolerance, dyslipidemia, and hypertension (34, 35); the total blood volume increases with increasing BMI through central (renin-angiotensin and sympathetic systems) and peripheral (e.g., baroreceptors and autonomic dysregulation) mechanisms (36); and insufficient MVPA might disrupt the lipid metabolism through inactivating the lipoprotein lipase and preventing C-reactive protein reduction (37). Thus, although dietary behaviors, MVPA, and weight status of offspring could be influenced by parental behaviors directly, changes in these behaviors with the passage of time could disturb the body homeostasis and result in abnormal BP, TC, and FPG (38–40). In addition, overweight and obesity have long been recognized as key indicators for cardiovascular diseases (41). The potential abnormal metabolic and cardiovascular indicators could pass down to offspring through epigenetic pathways if parents have been at overweight/obesity status for a long period (42, 43). Although phenotype was based on the heritability, there are differences between family-cluster phenotype and heritability owing to the interaction of gene and environment (44). For instance, frequent physical activity could mitigate the impact of genetic factors on the development of high BMI and waist circumference (45); and the specific contents of CVH status between two generations were different owing to the environment (15). Family-targeted improvement strategies should, therefore, be included to promote their offspring’s CVH status, and comprehensive interventions should be considered and encouraged at family’s dimensions.
Our study has practical values for public health. Since parental behaviors are modifiable and they are major contributors to ideal CVH status, only 15% of ideal CVH status is heritable (15). Parental healthy behaviors play a prominent part in the improving the CVH status of offspring under the context of Chinese culture of valuing family connections and supervision. We emphasize that even mild improvements of parental behaviors will benefit their offspring’s CVH status in the context of the dose–response relationship. In addition, as previously described (16), both single and combined unhealthy behaviors of parents would influence offspring’s nonideal CVH status, public service should encourage all parents to improve their healthy behaviors rather than only focus on those parents whose offspring had worse CVH status, and the whole family should be encouraged to be involved in the educational interventions to prevent unhealthy behaviors in children and adolescents.
The strength of the present study was the large sample size collected from seven Chinese provinces including all the economic and geographic regions, which made our findings be generalized to all Chinese school-age population. In addition, we used high-quality CVH factor measurements for offspring, including standardized protocols and repeated operations for anthropometric and BP measurements, as well as professional blood sample detection. In addition, we conducted multiple analyses for both parental unhealthy behaviors and offspring’s CVH status, making the results become more reliable. However, several limitations should be mentioned. First, information during pregnancy was absent, including maternal disease and prenatal care, which limited us to make further inferences. Second, the self-reported physical activity, parental height, and weight might not be as accurate as measured directly. However, self-reported physical activity has been proved to be useful in large epidemiological studies (46), and self-reported height and weight in adults were demonstrated to be highly reliable (47, 48). Third, potential selection bias might influence the results, but we adjusted for socioeconomic and sociodemographic variables in order to avoid the possible deviations to a large extent. In addition, we collected only one side of the parents’ behaviors, and thus whether maternal or paternal behaviors were more important on offspring CVH status could not be speculated. Finally, we only examined the associations between some of the parental behaviors (overweight/obesity, MVPA, and dietary behaviors) and offspring’s CVH status but did not include parental smoking status due to the limited information of the database. Prospective research studies examining more comprehensive behaviors’ regulations on such parent–offspring associations are still needed.
Conclusion
Parental overweight/obesity, insufficient MVPA, and unhealthy dietary behaviors were strongly associated with offspring’s nonideal CVH status, with dose–response associations. In addition, more unhealthy parental behaviors are associated with higher risks of childhood nonideal CVH status. Targets to improve parental lifestyle behaviors might facilitate the attainment of improving CVH status of offspring, and the whole family should be encouraged to be involved in the educational interventions to benefit to their offspring’s lifelong cardiovascular health.
Data availability statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Ethics statement
The studies involving human participants were reviewed and approved by the Medical Ethical Committee of Peking University (IRB No. 00001052-12072). Written informed consent to participate in this study was provided by the participants’ legal guardian/next of kin.
Author contributions
All authors contributed to conceiving and designing this study. QM and JL performed the data analysis. QM, MCu, MCh, TM, XW, DG, and YL interpreted, wrote, and finalized the manuscript. YW revised the manuscript. LC, YM, YZ, YD, YX, and JM participated in reviewing the manuscript. All authors contributed to the article and approved the submitted version.
Funding
This study was funded by the National Natural Science Foundation of China (grant 91846302) awarded to YX, the Research Special Fund for Public Welfare Industry of Health (201202010) awarded to JM, and the National Key R&D Program of China (2016YFA0501604) awarded to YX.
Acknowledgments
The authors are grateful to all children and their parents who participated in the study and all the staff involved in the study for data collection and measurements.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fped.2022.1052063/full#supplementary-material.
References
1. WHO. Cardiovascular diseases (CVDs), 11 June 2021. Available from: https://www.who.int/zh/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) (accessed January 3, 2022)
2. Ma LY, Chen WW, Gao RL, Liu LS, Zhu ML, Wang YJ, et al. China cardiovascular diseases report 2018: an updated summary. J Geriatr Cardiol. (2020) 17(1):1–8. doi: 10.11909/j.issn.1671-5411.2020.01.001
3. Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's Strategic Impact Goal through 2020 and beyond. Circulation. (2010) 121(4):586–613. doi: 10.1161/CIRCULATIONAHA.109.192703
4. Nguyen ATH, Saeed A, Bambs CE, Swanson J, Emechebe N, Mansuri F, et al. Usefulness of the American Heart Association’s ideal cardiovascular health measure to predict long-term major adverse cardiovascular events (from the heart SCORE study). Am J Cardiol. (2021) 138:20–5. doi: 10.1016/j.amjcard.2020.10.019
5. Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. N Engl J Med. (1998) 338(23):1650–6. doi: 10.1056/NEJM199806043382302
6. Li S, Chen W, Srinivasan SR, Bond MG, Tang R, Urbina EM, et al. Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA. (2003) 290(17):2271–6. doi: 10.1001/jama.290.17.2271
7. Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, Mäki-Torkko N, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA. (2003) 290(17):2277–83. doi: 10.1001/jama.290.17.2277
8. Dong H, Yan Y, Liu J, Zhao X, Cheng H, Hou D, et al. Alarming trends in ideal cardiovascular health among children and adolescents in Beijing, China, 2004 to 2014. Int J Cardiol. (2017) 231:264–70. doi: 10.1016/j.ijcard.2016.12.027
9. Shay CM, Ning H, Daniels SR, Rooks CR, Gidding SS, Lloyd-Jones DM. Status of cardiovascular health in US adolescents: prevalence estimates from the National Health and Nutrition Examination Surveys (NHANES) 2005–2010. Circulation. (2013) 127(13):1369–76. doi: 10.1161/CIRCULATIONAHA.113.001559
10. Abrignani MG, Lucà F, Favilli S, Benvenuto M, Rao CM, Di Fusco SA, et al. Lifestyles and cardiovascular prevention in childhood and adolescence. Pediatr Cardiol. (2019) 40(6):1113–25. doi: 10.1007/s00246-019-02152-w
11. Robson SM, Couch SC, Peugh JL, Glanz K, Zhou C, Sallis JF, et al. Parent diet quality and energy intake are related to child diet quality and energy intake. J Acad Nutr Diet. (2016) 116(6):984–90. doi: 10.1016/j.jand.2016.02.011
12. Xu H, Wen LM, Rissel C. Associations of parental influences with physical activity and screen time among young children: a systematic review. J Obes. (2015) 2015:546925. doi: 10.1155/2015/546925
13. Næss M, Holmen TL, Langaas M, Bjørngaard JH, Kvaløy K. Intergenerational transmission of overweight and obesity from parents to their adolescent offspring—the HUNT study. PLoS One. (2016) 11(11):e0166585. doi: 10.1371/journal.pone.0166585
14. Bahreynian M, Qorbani M, Khaniabadi BM, Motlagh ME, Safari O, Asayesh H, et al. Association between obesity and parental weight status in children and adolescents. J Clin Res Pediatr Endocrinol. (2017) 9(2):111–7. doi: 10.4274/jcrpe.3790
15. Muchira JM, Gona PN, Mogos MF, Stuart-Shor E, Leveille SG, Piano MR, et al. Temporal trends and familial clustering of ideal cardiovascular health in parents and offspring over the life course: an investigation using the Framingham Heart Study. J Am Heart Assoc. (2020) 9(12):e016292-e. doi: 10.1161/JAHA.120.016292
16. Perak AM, Lancki N, Kuang A, Labarthe DR, Allen NB, Shah SH, et al. Associations of maternal cardiovascular health in pregnancy with offspring cardiovascular health in early adolescence. JAMA. (2021) 325(7):658–68. doi: 10.1001/jama.2021.0247
17. Chen Y, Ma L, Ma Y, Wang H, Luo J, Zhang X, et al. A national school-based health lifestyles interventions among Chinese children and adolescents against obesity: rationale, design and methodology of a randomized controlled trial in China. BMC Public Health. (2015) 15:210. doi: 10.1186/s12889-015-1516-9
18. Yuan ZP, Yang M, Liang L, Fu JF, Xiong F, Liu GL, et al. Possible role of birth weight on general and central obesity in Chinese children and adolescents: a cross-sectional study. Ann Epidemiol. (2015) 25(10):748–52. doi: 10.1016/j.annepidem.2015.05.011
19. Liu J, Li Y, Wang X, Gao D, Chen L, Chen M, et al. Association between fruit consumption and lipid profile among children and adolescents: a national cross-sectional study in China. Nutrients. (2021) 14(1):63. doi: 10.3390/nu14010063
20. Gui ZH, Zhu YN, Cai L, Sun FH, Ma YH, Jing J, et al. Sugar-sweetened beverage consumption and risks of obesity and hypertension in Chinese children and adolescents: a national cross-sectional analysis. Nutrients. (2017) 9(12):1302. doi: 10.3390/nu9121302
21. Hicks TM, Knowles SO, Farouk MM. Global provisioning of red meat for flexitarian diets. Front Nutr. (2018) 5:50. doi: 10.3389/fnut.2018.00050
22. Group CSPaHR. Chinese students’ physical fitness and health research report 2010. Beijing: High Education Publication (2015).
23. China NHCotPsRo. Screening for overweight and obesity among school-age children and adolescents. Beijing (2018).
24. Commission CNH. Reference of screening for elevated blood pressure among children and adolescents aged 7–18 years. Report no. WS/T610-2018. Beijing: National Health Commission of the People's Republic of China (2018). p. 4–6 http://www.nhc.gov.cn/wjw/pqt/201807/6cee88c1d050493ab50a411a2978f901.shtml (accessed January 10, 2022)
25. The Chinese Dietary Guidelines (2016). Available from: http://dg.cnsoc.org/article/2016b.html (accessed January 3, 2022)
26. Muchira JM, Gona PN, Mogos MF, Stuart-Shor E, Leveille SG, Piano MR, et al. Parental cardiovascular health predicts time to onset of cardiovascular disease in offspring. Eur J Prev Cardiol. (2022) 29(6):883–91. doi: 10.1093/eurjpc/zwaa072
27. Physical activity guidelines for Chinese population (2021). Chinese CDC (2022). Available from: https://www.chinanutri.cn/yyjkzxpt/yyjkkpzx/hdjl/202201/t20220104_255480.html (accessed January 5, 2022)
28. Zhou BF. Effect of body mass index on all-cause mortality and incidence of cardiovascular diseases—report for meta-analysis of prospective studies open optimal cut-off points of body mass index in Chinese adults. Biomed Environ Sci. (2002) 15(3):245–52. PMID: 1250066512500665
29. Jääskeläinen A, Pussinen J, Nuutinen O, Schwab U, Pirkola J, Kolehmainen M, et al. Intergenerational transmission of overweight among Finnish adolescents and their parents: a 16-year follow-up study. Int J Obes (Lond). (2011) 35(10):1289–94. doi: 10.1038/ijo.2011.150
30. Ma L, Ding Y, Wen X, Gao L, Zhao L, Xue B, et al. Parent-child resemblance in BMI and obesity status and its correlates in China. Public Health Nutr. (2021) 24(16):5400–13. doi: 10.1017/S1368980020005108
31. Mahmood L, Flores-Barrantes P, Moreno LA, Manios Y, Gonzalez-Gil EM. The influence of parental dietary behaviors and practices on children’s eating habits. Nutrients. (2021) 13(4):1138. doi: 10.3390/nu13041138
32. Francis LA, Birch LL. Maternal influences on daughters’ restrained eating behavior. Health Psychol. (2005) 24(6):548–54. doi: 10.1037/0278-6133.24.6.548
33. Brotons C. Healthy habits and risk factors of parents can have long-term clinical consequences in their offspring. Eur J Prev Cardiol. (2022) 29(6):880–2. doi: 10.1093/eurjpc/zwaa111
34. Doostvandi T, Bahadoran Z, Mozaffari-Khosravi H, Mirmiran P, Azizi F. Food intake patterns are associated with the risk of impaired glucose and insulin homeostasis: a prospective approach in the Tehran Lipid and Glucose Study. Public Health Nutr. (2016) 19(13):2467–74. doi: 10.1017/S1368980016000616
35. Hosseini-Esfahani F, Hosseinpour-Niazi S, Asghari G, Bahadoran Z, Moslehi N, Golzarand M, et al. Nutrition and cardio-metabolic risk factors: findings from 20 years of the Tehran Lipid and Glucose Study. Int J Endocrinol Metab. (2018) 16(4 Suppl):e84772. doi: 10.5812/ijem.84772
36. Pausova Z. From big fat cells to high blood pressure: a pathway to obesity-associated hypertension. Curr Opin Nephrol Hypertens. (2006) 15(2):173–8. doi: 10.1097/01.mnh.0000214775.42103.a5
37. Sulague RM, Suan NNM, Mendoza MF, Lavie CJ. The associations between exercise and lipid biomarkers. Prog Cardiovasc Dis. (2022) 75:59–68. doi: 10.1016/j.pcad.2022.11.004
38. Gao J, Sun H, Liang X, Gao M, Zhao H, Qi Y, et al. Ideal cardiovascular health behaviors and factors prevent the development of hypertension in prehypertensive subjects. Clin Exp Hypertens. (2015) 37(8):650–5. doi: 10.3109/10641963.2015.1047938
39. Wang X, Dong B, Huang S, Ma Y, Zou Z, Ma J, et al. Body mass index trajectory and incident hypertension: results from a longitudinal cohort of Chinese children and adolescents, 2006–2016. Am J Public Health. (2020) 110(11):1689–95. doi: 10.2105/AJPH.2020.305873
40. Pacor JM, Younus A, Malik R, Osondu CU, Aziz M, Ogunmoroti O, et al. Prevalence of ideal cardiovascular health metrics in children & adolescents: a systematic review. Prog Pediatr Cardiol. (2016) 43:141–6. doi: 10.1016/j.ppedcard.2016.09.002
41. WHO. Obesity and overweight. Geneva: WHO (2021). Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (accessed January 7, 2022)
42. Jimenez-Chillaron JC, Isganaitis E, Charalambous M, Gesta S, Pentinat-Pelegrin T, Faucette RR, et al. Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Diabetes. (2009) 58(2):460–8. doi: 10.2337/db08-0490
43. Carpenter BL, Zhou W, Madaj Z, DeWitt AK, Ross JP, Grønbæk K, et al. Mother-child transmission of epigenetic information by tunable polymorphic imprinting. Proc Natl Acad Sci U S A. (2018) 115(51):E11970–7. doi: 10.1073/pnas.1815005115
44. Silventoinen K, Rokholm B, Kaprio J, Sørensen TI. The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies. Int J Obes (Lond). (2010) 34(1):29–40. doi: 10.1038/ijo.2009.177
45. Mustelin L, Silventoinen K, Pietiläinen K, Rissanen A, Kaprio J. Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins. Int J Obes (Lond). (2009) 33(1):29–36. doi: 10.1038/ijo.2008.258
46. Welk GJ, Corbin CB, Dale D. Measurement issues in the assessment of physical activity in children. Res Q Exerc Sport. (2000) 71(2 Suppl):S59–73. doi: 10.1080/02701367.2000.11082788
47. Peixoto Mdo R, Benício MH, Jardim PC. Validity of self-reported weight and height: the Goiânia study, Brazil. Rev Saude Publica. (2006) 40(6):1065–72. doi: 10.1590/S0034-89102006000700015
Keywords: lifestyle, cardiovascular health, parents, offspring, cross-sectional study
Citation: Ma Q, Liu J, Wu Y, Cui M, Chen M, Ma T, Wang X, Gao D, Li Y, Chen L, Ma Y, Zhang Y, Dong Y, Xing Y and Ma J (2023) Association between parental unhealthy behaviors and offspring’s cardiovascular health status: Results from a cross-sectional analysis of parent–offspring pairs in China. Front. Pediatr. 10:1052063. doi: 10.3389/fped.2022.1052063
Received: 23 September 2022; Accepted: 5 December 2022;
Published: 6 January 2023.
Edited by:
Shikai Yu, Tongji University, ChinaReviewed by:
Hongwei Ji, The Affiliated Hospital of Qingdao University, ChinaShanquan Chen, University of Cambridge, United Kingdom
© 2023 Ma, Liu, Wu, Cui, Chen, Ma, Wang, Gao, Li, Chen, Ma, Zhang, Dong, Xing and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yi Xing cyrss@126.com
Specialty Section: This article was submitted to Pediatric Cardiology, a section of the journal Frontiers in Pediatrics