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CORRECTION article

Front. Cell Dev. Biol., 28 March 2022
Sec. Cell Death and Survival
Volume 10 - 2022 | https://doi.org/10.3389/fcell.2022.876000

Corrigendum: Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition

www.frontiersin.orgLan Huang1,2 www.frontiersin.orgBo Peng2† www.frontiersin.orgYash Nayak2† www.frontiersin.orgCindy Wang2 www.frontiersin.orgFusheng Si2 www.frontiersin.orgXia Liu2 www.frontiersin.orgJie Dou3 www.frontiersin.orgHuaxi Xu1* www.frontiersin.orgGuangyong Peng2*
  • 1Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China
  • 2Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, School of Medicine, Saint Louis University, Saint Louis, MO, United States
  • 3State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China

A corrigendum on
Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition

by Huang, L., Peng, B., Nayak, Y., Wang, C., Si, F., Liu, X., Dou, J., Xu, H. and Peng, G. (2020). Front. Cell Dev. Biol. 8:836. doi:10.3389/fcell.2020.00836

In the original article, there were mistakes in Figures 2B,C as published. “We misused some data for both cell lines in Figure 2B. In addition, we made mistakes and uploaded the wrong images for some time points and treatments in Figure 2C.” The corrected Figure 2 appears below.

FIGURE 2
www.frontiersin.org

FIGURE 2. Baicalein and baicalin inhibit melanoma cell colony formation, migration and adhesion. (A,B) Baicalein and baicalin treatments dramatically decreased the numbers and sizes of tumor colonies in SK-MEL-2 and A375 cells. 200–500 per well of melanoma cells pre-treated with the indicated concentrations of baicalein or baicalin, were seeded in 6-well plates for culture, and cell colonies counted after 10–14 days of culture. Results shown in the histogram (B) are summaries of mean ± SD from three independent experiments. **p < 0.01 compared with the medium control group. (C) Different concentrations of baicalein and baicalin treatments in both human and mouse melanoma cells significantly inhibited tumor cell migration compared with the medium control group at 24 and 36 h time points in the wound closure assays. Data shown are representatives from three independent experiments with similar results. (D) Baicalein and baicalin treatments suppressed the adhesion of melanoma cells. Both human and mouse melanoma cells pretreated with the indicated concentrations of baicalein and baicalin were cultured in the fibronectin-coated plates for 45 min. Adherent cells were counted and averaged in 10 fields at high (×400) magnification with a microscope. Results shown are summaries of mean ± SD from three independent experiments with similar results **p < 0.01 compared with the medium control group.

The authors apologize for the errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher’s Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: baicalein, baicalin, melanoma, N-RAS, B-RAF, apoptosis, senescence, glucose metabolism

Citation: Huang L, Peng B, Nayak Y, Wang C, Si F, Liu X, Dou J, Xu H and Peng G (2022) Corrigendum: Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition. Front. Cell Dev. Biol. 10:876000. doi: 10.3389/fcell.2022.876000

Received: 14 February 2022; Accepted: 03 March 2022;
Published: 28 March 2022.

Edited and reviewed by:

You-Wen He, Duke University, United States

Copyright © 2022 Huang, Peng, Nayak, Wang, Si, Liu, Dou, Xu and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Huaxi Xu, xuhx@ujs.edu.cn; Guangyong Peng, guangyong.peng@health.slu.edu

†Present address: Bo Peng, Yash Nayak, Washington University in St. Louis, St. Louis, MO, United States

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