Sleep fragmentation is associated with brain tau but not amyloid-β burden in healthy older adults
Daphne
Chylinski1*,
Franziska
Rudzik2,
Dorothée
Coppieters 'T Wallant3,
Maxime
Van Egroo1,
Vincenzo
Muto1,
Justinas
Narbutas1, 4,
Pamela
Villar González1,
Gabriel
Besson1,
Eric
Lambot1,
Sophie
Laloux1,
Catherine
Hagelstein1,
Pouya
Ghaemmaghami1,
Christian
Degueldre1,
Christian
Berthomier5,
Pierre
Bethomier5,
Marie
Brandewinder5,
Christina
Schmidt1, 4,
Pierre
Maquet1, 6,
Eric
Salmon1, 4, 7,
Christophe
Phillips1, 8,
Mohamed Ali
Bahri1,
Christine
Bastin1, 4,
Fabienne
Collette1, 4 and
Gilles
Vandewalle1
-
1
GIGA-Cyclotron Research Center In Vivo Imaging, University of Liege, Belgium
-
2
Zentrum für Chronobiologie, Universität Basel, Switzerland
-
3
Department of Electrical Engineering and Computer Science, University of Liège, Belgium
-
4
Psychology and Cognitive Neuroscience Research Unit, University of Liège, Belgium, Belgium
-
5
Physip S.A, France
-
6
Department of Neurology, University Hopital of Liege, Belgium
-
7
Department of Neurology, University Hospital Liège, Belgium
-
8
GIGA-In silico Medicine, University of Liège, Belgium
INTRODUCTION – Arousal during sleep are transient shifts in EEG frequency lasting at least 3 seconds that are thought to reflect poorer sleep quality. Their impact on brain function and brain structure is however not established. In addition, accumulating evidence support a strong link between sleep-wake dysfunction and the pathogenesis of Alzheimer’s disease (AD), including the abnormal accumulation of amyloid-β (Aβ) and tau protein in the brain. Here we investigated whether arousals during sleep are associated with Aβ and Tau burden in healthy aging.
METHODS – Fifty-four healthy and cognitively normal older individuals (aged 51-69; mean 59 ± 5; 36 females) were tested in this study. We recorded their night time sleep in the laboratory under EEG and assessed Aβ and tau protein burden during two Positron Emission Tomography (PET) scans, respectively with 18F-flutemetamol and 18F-THK 5351 radiotracers. Automatic sleep stage scoring and arousal detection was computed on all EEG recordings.
RESULTS – Generalized linear mixed models analyses revealed that the number of arousals with a concomitant increase in EMG tone was significantly associated with whole-brain tau burden (p = .009), but not with whole-brain Aβ burden (p = .30), even when correcting for age, sex, education and total sleep time. Further analyses showed that sleep macrostructure parameters such as sleep onset latency, wake after sleep onset, sleep efficiency were not significantly associated to whole-brain F18-THK 5351 or F18-flutemetamol intake values.
CONCLUSION – These findings suggest that arousals during sleep are strongly linked to whole-brain AD pathophysiology, namely the accumulation of tau, but not Aβ. These results cast new light on the association between sleep and AD pathophysiology.
Acknowledgements
Support: FNRS,ULiège,ARC17/21-09,FEDER,WBI,Clerdent Foundation
Keywords:
Sleep,
Aging,
Alzheimer's disease pathophysiology,
arousals,
Tau & phospho-Tau protein,
Beta - amyloid protein
Conference:
Belgian Brain Congress 2018 — Belgian Brain Council, LIEGE, Belgium, 19 Oct - 19 Oct, 2018.
Presentation Type:
e-posters
Topic:
NOVEL STRATEGIES FOR NEUROLOGICAL AND MENTAL DISORDERS: SCIENTIFIC BASIS AND VALUE FOR PATIENT-CENTERED CARE
Citation:
Chylinski
D,
Rudzik
F,
Coppieters 'T Wallant
D,
Van Egroo
M,
Muto
V,
Narbutas
J,
Villar González
P,
Besson
G,
Lambot
E,
Laloux
S,
Hagelstein
C,
Ghaemmaghami
P,
Degueldre
C,
Berthomier
C,
Bethomier
P,
Brandewinder
M,
Schmidt
C,
Maquet
P,
Salmon
E,
Phillips
C,
Bahri
M,
Bastin
C,
Collette
F and
Vandewalle
G
(2019). Sleep fragmentation is associated with brain tau but not amyloid-β burden in healthy older adults.
Front. Neurosci.
Conference Abstract:
Belgian Brain Congress 2018 — Belgian Brain Council.
doi: 10.3389/conf.fnins.2018.95.00054
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Received:
20 Aug 2018;
Published Online:
17 Jan 2019.
*
Correspondence:
Miss. Daphne Chylinski, GIGA-Cyclotron Research Center In Vivo Imaging, University of Liege, Liège, Belgium, daphne.chylinski@uliege.be