Yonsei Med J. 2004 Apr;45(2):359-361. English.
Published online Feb 17, 2009.
https://doi.org/10.3349/ymj.2004.45.2.359
Published online Feb 17, 2009.
https://doi.org/10.3349/ymj.2004.45.2.359
Copyright © 2004 The Yonsei University College of Medicine
Brief Communication
Cloning of TLR3 Isoform
Eun Jeong Yang,1,3
Jeon Soo Shin,1,2,3
Hyemi Kim,1,3
Hyoung Woo Park,4
Myoung Hee Kim,4
Se Jong Kim,1,2,3
and In Hong Choi1,2,3
Abstract
Toll-like receptor (TLR) 3 is a member of the TLR family that confers innate immunity by recognizing viral pathogens. Herein, we report that the TLR3 isoform is expressed on human primary cells and cell lines. This isoform has 2, 520 bp cDNAs compared to the 2, 712 bp of full cDNA, is produced by deletion of an intron-like sequence within exon 4 and is co-expressed with wild type TLR3 in primary human astrocytes and glioblastoma cell lines. This finding suggests the TLR3 isoform in astrocytes may have a different immunological role for binding ligands during the immune response in brain.
Keywords
Human TLR3; isoform
MeSH Terms
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