Yonsei Med J. 1971;12(1):13-16. English.
Published online Feb 20, 2002.
https://doi.org/10.3349/ymj.1971.12.1.13
Published online Feb 20, 2002.
https://doi.org/10.3349/ymj.1971.12.1.13
Copyright © 1971 The Yonsei University College of Medicine
Original Article
Urea Synthesis in the Intact and in the Isolated Perfused Liver of the Biotin-Deficient Rats
Je Hyun Kim,
Moo Youn Cho,
Byung Woo Kim
and Chug Suk Song
Abstract
Biotin-deficient rats were raised on a purified ration containing raw egg white plus avidin. Urea synthesis and excretion were compared between the biotin-deficient and the pair-fed control rats. 24hrurinary urea excretion and the specific activities of carbamylphosphate synthetase, ornithine transcarbamylase, and arginase in the liver mitochondria fraction were no different between these two groups.
The net urea production in the liver slice and in the isolated perfused liver of the biotin-deficient rats was similar to that of the pair-fed control. Thus the conclusion must be that biotin is not in urea in mea biosynthesis in the rat.
Cited by
MeSH Terms
Permalink information copied to clipboard