CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS

Gülderen Yılmaz; Gulnur Ekşi; Betül Demirci; Fatih Demirci

doi:10.33483/jfpau.645467

Araştırma Makalesi

TÜRKİYE'DE DOĞAL OLARAK YETİŞEN VE AKTARLARDA SATILAN SUMAK (RHUS CORIARIA L.) MEYVELERİNİN YAĞ ASİDİ KOMPOZİSYONLARININ KİMYASAL KARAKTERİZASYONU VE ANTİMİKROBİYAL AKTİVİTESİ

Yıl 2020, Cilt: 44 Sayı: 1, 61 - 69, 31.01.2020

Gülderen Yılmaz Gulnur Ekşi Betül Demirci Fatih Demirci

https://doi.org/10.33483/jfpau.645467

Cited By: 2

Öz

Amaç: Bu çalışma Tunceli ve Siirt ilerinde doğal
olarak yayılış gösteren örnekler ile aktarlarda toz ve tane olarak satılan R.
coriaria L. örneklerinin yağ asiti bileşenleri ve antimikrobiyal özelliklerini
karşılaştırmak amacı ile yapılmıştır.

Gereç ve
Yöntem: Tohumlar tartıldıktan ve toz
haline getirildikten sonra soksalet kullanarak sabit yağları elde edilmiştir.
Elde edilen sabit yağların, metilleme işlemi yapıldıktan sonra, GC ve GC/MS
yöntemleriyle eş zamanlı olarak analizleri gerçekleştirilmiştir. Sabit yağ
numunelerinin in vitro antimikrobiyal aktivite çalışmaları altı farklı Gram
negatif ve Gram pozitif bakteri ve Candida albicans’a karşı EUCAST disk
difüzyon ve CLSI mikrodilüsyon yöntemleri kullanılarak gerçekleştirilmiştir.

Sonuç ve
Tartışma: Tüm
numunelerin ana yağ asidi bileşenleri, sırasıyla oleik asit (%42.2 - 43.3),
linoleik asit (%25.2 - 28.5) ve palmitik asit (%18.4-221.5) olarak tanımlandı.
Sabit yağların in vitro antimikrobiyal aktivitesi, Escherichia coli NRRL
B-3008, Staphylococcus aureus ATCC 6538, S. epidermidis ATCC 14990, Pseudomonas
aeruginosa ATCC 27853, Bacillus subtilis NRRL B-A78 A78 gibi insan patojenik
mikroorganizmalarına karşı gerçekleştirildi. Sonuçlar standart antimikrobiyal
maddeler ile karşılaştırılmış ve MIC değerleri > 2,5 - 0.22 mg/ml
belirlenmiştir. Sonuçların antimikrobiyal etkinlik açından kayda değer olduğu
görülmüştür.

Anahtar Kelimeler

Antimikrobial, CLSI, EUCAST, GC-FID, GC-MS, Rhus coriaria

Kaynakça

1. The Plant List: Version 1(accessed 29 Jan 2019).1. Available from: http://www.theplantlist.org/
2. Brunke E-J, Hammerschmidt F-J, Schmaus G, Akgül (1993). A The essential oil of Rhus coriaria L. fruits. Flavour Fragr J. 8: 209-214.
3. Abu-Reidah IM, Jamous RM, Ali-Shtayeh MS. (2014). Phytochemistry, Pharmacological Properties and Industrial Applications of Rhus coriaria L. (Sumac). Jordan J. Biol. Sci. 4: 233-244.
4. Abu-Reidah IM, Ali-Shtayeh MS, Jamous RM, Arráez-Román D, Segura-Carretero A. (2015). HPLC-DAD-ESI-MS/MS screening of bioactive components from Rhus coriaria L. (Sumac) fruits. Food Chem. 166: 179-191.
5. Rayne S, Mazza G. (2007). Biological activities of extracts from sumac (Rhus spp.): A review. Plant Foods Hum Nutr. 62: 165-175.
6. Azcan N, Ertan A, Demirci B, Başer KHC. Fatty acid composition of seed oils of twelve Salvia species growing in Turkey. Chem Nat Compd. 2004; 40: 218-221. 7. ESO 2000. (1999). The complete database of essential oils Boelens Aroma Chemical Information Service. The Netherlands.
8. Joulain D, Konig WA. (1998). The atlas of spectral data of sesquiterpene hydrocarbons. J Nat Prod. 62: 1212-1213. 9. Jennings WG, Shibamoto T. (1980). Quantitative Analysis of Flavor and Fragrance Volatiles by Glass Capillary GC; Academic Press: New York.
10. McLafferty FW, Stauffer DB. (1989.) The Wiley. NBS registry of mass spectral data; Wiley. New York.
11. Koenig WA, Joulain D, Hochmuth DH. (2004). Terpenoids and related constituents of essential oils. MassFinder 3. In: Hochmuth DH, ed. Convenient and Rapid Analysis of GCMS. Hamburg, Germany; pp 493.
12. Jones RN. (1992) Recent trends in the college of American pathologists proficiency results for antimicrobial susceptibility testing: Preparing for CLIA’88. Clin Microbio. Newsl. 14: 33-37.
13. Matuschek E, Brown DFJ, Kahlmeter G. (2014). Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories. Clin Microbiol Infec. 20: 255-266.
14. Demirci B, Toyota M, Demirci F, Dadandi MY, Başer KHC. (2009). Anticandidal Pimaradiene Diterpene from Phlomis Essential Oils. C R Chim. 12: 612-621.
15. CLSI. (2007). Performance Standards for Antimicrobial Susceptibility Testing; Seventeenth Informational Supplement, M100-S17, Clinical and Laboratory Standards Institute, 27(1).
16. Clinical and Laboratory Standards Institute M7-A7. (2006). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard-Seventh Edition, CLSI document, 26(2).
17. Clinical and Laboratory Standards Institute M27-A2. (2002). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard-Second Edition, CLSI document, 22(15).
18. EUCAST. (2015). European Society of Clinical Microbiology and Infectious Diseases, Antimicrobial susceptibility testing EUCAST disk diffusion method Version 5.0.
19. Croxatto A, Prodhom G, Greub G. (2012). Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology. Fems Microbiol Rev. 36: 380-407.
20. Doğan M, Akgül A. (2005) Characteristics and fatty acid compositions of Rhus coriaria cultivars from southeast Turkey. Chem Nat Compd. 41: 724-725. 21. Ünver A, Özcan MM. Fatty acid composition of seed and pericarp of sumach (Rhus coriaria L.) grown wild in different regions of Turkey. J Food Agric Environ. 2010; 8: 31-33.
22. Nimri LF, Meqdam MM, Alkofahi A. (1999). Antibacterial Activity of Jordanian Medicinal Plants. Pharm Biol. 37: 196-201.
23. Nasar-Abbas SM, Halkman AK. (2004). Antimicrobial effect of water extract of sumac (Rhus coriaria L.) on the growth of some food borne bacteria including pathogens. Int J Food Microbiol. 97: 63-69.
24. Adwan G, Abu-Shanab B, Adwan K, Abu-Shanab F. (2006). Antibacterial effects of nutraceutical plants growing in Palestine on Pseudomonas aeruginosa. Turk J Biol. 30: 239-242.
25. Fazeli MR, Amin G, Attari MMA, Ashtiani H, Jamalifar H, Samadi N. (2007). Antimicrobial activities of Iranian sumac and avishan-e shirazi (Zataria multiflora) against some food-borne bacteria. Food Control. 18: 646-649.
26. Saǧdıç O, Özcan M. (2002). Antibacterial activity of Turkish spice hydrosols. Food Control. 14: 141-143.

CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS

Yıl 2020, Cilt: 44 Sayı: 1, 61 - 69, 31.01.2020

Gülderen Yılmaz Gulnur Ekşi Betül Demirci Fatih Demirci

https://doi.org/10.33483/jfpau.645467

Cited By: 2

Öz

ABSTRACT

Objective:
The aim of this study was to compare the fatty acid components and
antimicrobial properties of R. coriaria L. samples which were sold as powder and grains
tjat show natural distribution in Tunceli and Siirt.

Material and Method: After the
seeds were weighed and powdered, fixed oils were obtained by using soxhalet
apparatus. Obtained fixed oils were analyzed by GC and GC / MS methods after
methylation process. In vitro antimicrobial activity studies of the
samples were performed using six different Gram negative and Gram positive
bacteria and Candida albicans using EUCAST disc diffusion and CLSI
microdilution methods.

Results and Discussion: The main fatty
acid components of all samples were determined as oleic acid (42.2 - 43.3%),
linoleic acid (25.2 - 28.5%) and palmitic acid (18.4-221.5%), respectively. In
vitro antimicrobial activity of fixed oils, such as Escherichia coli NRRL
B-3008, Staphylococcus aureus ATCC 6538, S. epidermidis ATCC 14990, Pseudomonas
aeruginosa ATCC 27853, Bacillus subtilis NRRL B-A78 A78 Ausugusar ATC 27853.
Results were compared with standard antimicrobial agents and MIC values> 2.5
- 0.22 mg / mL. The results were found to be significant in terms of
antimicrobial efficacy.

Anahtar Kelimeler

Rhus coriaria, GC-FID, GC-MS, EUCAST, CLSI, antimicrobial

Kaynakça

1. The Plant List: Version 1(accessed 29 Jan 2019).1. Available from: http://www.theplantlist.org/
2. Brunke E-J, Hammerschmidt F-J, Schmaus G, Akgül (1993). A The essential oil of Rhus coriaria L. fruits. Flavour Fragr J. 8: 209-214.
3. Abu-Reidah IM, Jamous RM, Ali-Shtayeh MS. (2014). Phytochemistry, Pharmacological Properties and Industrial Applications of Rhus coriaria L. (Sumac). Jordan J. Biol. Sci. 4: 233-244.
4. Abu-Reidah IM, Ali-Shtayeh MS, Jamous RM, Arráez-Román D, Segura-Carretero A. (2015). HPLC-DAD-ESI-MS/MS screening of bioactive components from Rhus coriaria L. (Sumac) fruits. Food Chem. 166: 179-191.
5. Rayne S, Mazza G. (2007). Biological activities of extracts from sumac (Rhus spp.): A review. Plant Foods Hum Nutr. 62: 165-175.
6. Azcan N, Ertan A, Demirci B, Başer KHC. Fatty acid composition of seed oils of twelve Salvia species growing in Turkey. Chem Nat Compd. 2004; 40: 218-221. 7. ESO 2000. (1999). The complete database of essential oils Boelens Aroma Chemical Information Service. The Netherlands.
8. Joulain D, Konig WA. (1998). The atlas of spectral data of sesquiterpene hydrocarbons. J Nat Prod. 62: 1212-1213. 9. Jennings WG, Shibamoto T. (1980). Quantitative Analysis of Flavor and Fragrance Volatiles by Glass Capillary GC; Academic Press: New York.
10. McLafferty FW, Stauffer DB. (1989.) The Wiley. NBS registry of mass spectral data; Wiley. New York.
11. Koenig WA, Joulain D, Hochmuth DH. (2004). Terpenoids and related constituents of essential oils. MassFinder 3. In: Hochmuth DH, ed. Convenient and Rapid Analysis of GCMS. Hamburg, Germany; pp 493.
12. Jones RN. (1992) Recent trends in the college of American pathologists proficiency results for antimicrobial susceptibility testing: Preparing for CLIA’88. Clin Microbio. Newsl. 14: 33-37.
13. Matuschek E, Brown DFJ, Kahlmeter G. (2014). Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories. Clin Microbiol Infec. 20: 255-266.
14. Demirci B, Toyota M, Demirci F, Dadandi MY, Başer KHC. (2009). Anticandidal Pimaradiene Diterpene from Phlomis Essential Oils. C R Chim. 12: 612-621.
15. CLSI. (2007). Performance Standards for Antimicrobial Susceptibility Testing; Seventeenth Informational Supplement, M100-S17, Clinical and Laboratory Standards Institute, 27(1).
16. Clinical and Laboratory Standards Institute M7-A7. (2006). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard-Seventh Edition, CLSI document, 26(2).
17. Clinical and Laboratory Standards Institute M27-A2. (2002). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard-Second Edition, CLSI document, 22(15).
18. EUCAST. (2015). European Society of Clinical Microbiology and Infectious Diseases, Antimicrobial susceptibility testing EUCAST disk diffusion method Version 5.0.
19. Croxatto A, Prodhom G, Greub G. (2012). Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology. Fems Microbiol Rev. 36: 380-407.
20. Doğan M, Akgül A. (2005) Characteristics and fatty acid compositions of Rhus coriaria cultivars from southeast Turkey. Chem Nat Compd. 41: 724-725. 21. Ünver A, Özcan MM. Fatty acid composition of seed and pericarp of sumach (Rhus coriaria L.) grown wild in different regions of Turkey. J Food Agric Environ. 2010; 8: 31-33.
22. Nimri LF, Meqdam MM, Alkofahi A. (1999). Antibacterial Activity of Jordanian Medicinal Plants. Pharm Biol. 37: 196-201.
23. Nasar-Abbas SM, Halkman AK. (2004). Antimicrobial effect of water extract of sumac (Rhus coriaria L.) on the growth of some food borne bacteria including pathogens. Int J Food Microbiol. 97: 63-69.
24. Adwan G, Abu-Shanab B, Adwan K, Abu-Shanab F. (2006). Antibacterial effects of nutraceutical plants growing in Palestine on Pseudomonas aeruginosa. Turk J Biol. 30: 239-242.
25. Fazeli MR, Amin G, Attari MMA, Ashtiani H, Jamalifar H, Samadi N. (2007). Antimicrobial activities of Iranian sumac and avishan-e shirazi (Zataria multiflora) against some food-borne bacteria. Food Control. 18: 646-649.
26. Saǧdıç O, Özcan M. (2002). Antibacterial activity of Turkish spice hydrosols. Food Control. 14: 141-143.

Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Eczacılık ve İlaç Bilimleri
Bölüm	Araştırma Makalesi
Yazarlar	Gülderen Yılmaz 0000-0002-6569-4766 Gulnur Ekşi 0000-0002-6869-8703 Betül Demirci 0000-0003-2343-746X Fatih Demirci 0000-0003-1497-3017
Yayımlanma Tarihi	31 Ocak 2020
Gönderilme Tarihi	12 Kasım 2019
Kabul Tarihi	13 Aralık 2019
Yayımlandığı Sayı	Yıl 2020 Cilt: 44 Sayı: 1

Kaynak Göster

APA	Yılmaz, G., Ekşi, G., Demirci, B., Demirci, F. (2020). CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS. Journal of Faculty of Pharmacy of Ankara University, 44(1), 61-69. https://doi.org/10.33483/jfpau.645467
AMA	Yılmaz G, Ekşi G, Demirci B, Demirci F. CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS. Ankara Ecz. Fak. Derg. Ocak 2020;44(1):61-69. doi:10.33483/jfpau.645467
Chicago	Yılmaz, Gülderen, Gulnur Ekşi, Betül Demirci, ve Fatih Demirci. “CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS”. Journal of Faculty of Pharmacy of Ankara University 44, sy. 1 (Ocak 2020): 61-69. https://doi.org/10.33483/jfpau.645467.
EndNote	Yılmaz G, Ekşi G, Demirci B, Demirci F (01 Ocak 2020) CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS. Journal of Faculty of Pharmacy of Ankara University 44 1 61–69.
IEEE	G. Yılmaz, G. Ekşi, B. Demirci, ve F. Demirci, “CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS”, Ankara Ecz. Fak. Derg., c. 44, sy. 1, ss. 61–69, 2020, doi: 10.33483/jfpau.645467.
ISNAD	Yılmaz, Gülderen vd. “CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS”. Journal of Faculty of Pharmacy of Ankara University 44/1 (Ocak 2020), 61-69. https://doi.org/10.33483/jfpau.645467.
JAMA	Yılmaz G, Ekşi G, Demirci B, Demirci F. CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS. Ankara Ecz. Fak. Derg. 2020;44:61–69.
MLA	Yılmaz, Gülderen vd. “CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS”. Journal of Faculty of Pharmacy of Ankara University, c. 44, sy. 1, 2020, ss. 61-69, doi:10.33483/jfpau.645467.
Vancouver	Yılmaz G, Ekşi G, Demirci B, Demirci F. CHEMICAL CHARACTERIZATION OF THE FATTY ACID COMPOSITIONS AND ANTMICROBIAL ACTIVITY OF SUMAC (RHUS CORIARIA L.) FRUITS, GROWING NATURALLY IN TURKEY AND SOLD IN HERBALIST MARKETS. Ankara Ecz. Fak. Derg. 2020;44(1):61-9.

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https://doi.org/10.33483/jfpau.863486

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https://doi.org/10.17776/csj.714200

Kapak Resmi İndir

Makale Dosyaları

Tam Metin

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.