J Korean Med Sci. 1999 Dec;14(6):671-674. English.
Published online Jun 22, 2009.
https://doi.org/10.3346/jkms.1999.14.6.671
Published online Jun 22, 2009.
https://doi.org/10.3346/jkms.1999.14.6.671
Copyright © 1999 The Korean Academy of Medical Sciences
Case Report
Hepatosplenic B-cell lymphoma associated with hemophagocytic syndrome: a case report
Sang Yong Kwon,
Je Jung Lee,
Ik Joo Chung,
Hyeoung Joon Kim,
Moo Rim Park,
Hyung Seok Kim
and Chang Soo Park
Abstract
While T-cell non-Hodgkin's lymphoma (NHL) associated with hemophagocytic syndrome (HPS) has been frequently observed, B-cell NHL associated with HPS has been rarely reported. We report a case of hepatosplenic B-cell lymphoma associated with HPS in a 41-year-old woman who presented with fever of unknown origin. An abdominal CT scan revealed splenomegaly with focal splenic infarction. Splenectomy and a liver wedge biopsy showed sinusoidal-pattern infiltration of medium to large tumor cells with positive reaction to a B-lymphocyte marker. Findings on bone marrow examination showed proliferation of histiocytes with avid hemophagocytosis.
Keywords
Lymphoma, B-cell; Histiocytosis, malignant; Liver neoplasms; Splenic neoplasms; Neoplasms, multiple primary
MeSH Terms
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