| Optic Neuropathy after Taking Linezolid. |
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Yo Sep Yoon, Chang Kyu Lee |
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Department of Ophthalmology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. coolleo@uuh.ulsan.kr |
| 리네졸리드 복용 후 발생한 시신경병증 |
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윤요셉 · 이창규 |
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울산대학교 의과대학 울산대학교병원 안과학교실 |
Correspondence:
Chang Kyu Lee,
Email: coolleo@uuh.ulsan.kr
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Received: 12 July 2019 • Revised: 19 August 2019 • Accepted: 6 December 2019 |
| Abstract |
PURPOSE
We report a case of optic neuropathy in a patient who was treated with pre-extensively drug-resistant tuberculosis(pre-XDR TB) treatment with linezolid. CASE SUMMARY: A 61-year-old male patient with no other underlying disease was diagnosed with pre-XDR Tb 6 months before and took the TB drug at another hospital. Ethambolol was not prescribed because it was resistant from the beginning of TB treatment. Threrefore, linezolid was included for treatment of pre-XDR TB. The patient's best corrected visual acuity was 20/400 in both eyes at the time of outpatient visit. In Ishihara color vision test, both eyes showed complete color blindness. There was no detectable relative afferent pupillary defect, and fundus examination showed hyperemic optic discs and visual field examination showed both central visual field defects. Linezolid induced optic neuropathy was suspected, the drug was discontinued. After one month, the patient's best corrected visual acuity recovered to 20/20 in both eyes, and visual field and color vision returned to normal at 3 months. CONCLUSIONS: Linezolid is a broad spectrum antibiotic and is a useful drug for the treatment of broad-spectrum tuberculosis. However, since long-term use may cause optic neuropathy, the possibility of optic neuropathy should always be considered. If optic neuropathy is suspected, prompt drug withdrawal is required and reversible clinical changes can be expected. |
| Key Words:
Linezolid induced optic neuropathy;Tuberculosis |
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