| Efficacy of Plasma Exchange Therapy for Steroid-Unresponsive Neuromyelitis Optica. |
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Seong Ho Jo, Jae Hwan Choi, Hee Yonng Choi, Jae Ho Jung |
1Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Busan, Korea. jaeho0130@naver.com
2Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Busan, Korea.
3Department of Ophthalmology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. |
| 스테로이드 무반응 시신경척수염 환자에서 혈장분리교환술의 효과 |
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조성호1⋅최재환2⋅최희영3⋅정재호1 |
Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine1, Busan, Korea
Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine2, Busan, Korea
Department of Ophthalmology, Pusan National University Hospital, Pusan National University School of Medicine3, Busan, Korea |
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| Abstract |
PURPOSE
To report the therapeutic efficacy of plasma exchange therapy on steroid-unresponsive neuromyelitisoptica (NMO) patients. CASE SUMMARY: Three patients who had not achieved improvement of visual acuity and visual field after high steroid pulse therapy after optic neuritis visited our clinic with decreasing visual acuity combined with eye pain in the other eye. All patients were diagnosed as neuromyelitisoptica (NMO) based on the presence of NMO-IgG antibody and optic nerve enhancing in contrast-enhanced orbital magnetic resonance imaging (MRI). Recurrent optic neuritis was observed. Steroid pulse retreatment was started but visual acuity was not improved in all patients. The patients received plasma exchange therapy, followed by immune suppression therapy. All patients showed improved visual acuity and restored visual field promptly without recurrence of neuromyelitisoptica. CONCLUSIONS: In case of steroid-unresponsive neuromyelitisoptica, plasma exchange should be promptly considered as the treatment of choice. |
| Key Words:
Neuromyelitisoptica;Plasma exchange;Steroid pulse therapy |
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