Infective Endocarditis-Associated Glomerulonephritis: A Comprehensive                    Review of the Clinical Presentation, Histopathology, and                    Management

Tomoaki Takata; Yukari Mae; Takaaki Sugihara; Hajime Isomoto

doi:10.33160/yam.2022.02.011

Review Article

Infective Endocarditis-Associated Glomerulonephritis: A Comprehensive Review of the Clinical Presentation, Histopathology, and Management

Tomoaki Takata, Yukari Mae, Takaaki Sugihara, Hajime Isomoto

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Keywords: acute kidney injury, anti-neutrophil cytoplasmic antibody, infection-related glomerulonephritis, infective endocarditis-associated glomerulonephritis, rapidly progressive glomerulonephritis

JOURNAL FREE ACCESS

2022 Volume 65 Issue 1 Pages 1-7

DOI https://doi.org/10.33160/yam.2022.02.011

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Abstract

A significant proportion of patients with infective endocarditis presents with acute renal failure related to infective endocarditis-associated glomerulonephritis (IEAGN). However, the clinical presentation of IEAGN differs from that of other infection-related glomerulonephritis (IRGN) with anti-neutrophil cytoplasmic antibody (ANCA) positivity occurring in almost one-third of cases; therefore, it may be difficult to establish a definitive diagnosis and provide appropriate treatment. This review article provides a comprehensive understanding of the clinical presentation, investigations, histopathology, and treatment/management of IEAGN so that clinicians can keep this differential in mind for patients with fever of unknown origin accompanied by signs and symptoms of acute renal failure.

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