Saebi Rad F, Haghparast A, Eliassi A. Ventral Tegmental Area Microinjected-SKF38393 Increases Regular Chow Intake in 18 Hours Food-Deprived Rats. BCN 2020; 11 (6) :773-780
URL:
http://bcn.iums.ac.ir/article-1-1660-en.html
1- Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Physiology, School of Medical, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Introduction: Ventral Tegmental Area (VTA) dopamine neurons play an important role in reward mechanisms of food intake, and VTA dopamine receptors exist on the terminal of glutamatergic and GABAergic neurons and regulate Gamma-Aminobutyric Acid (GABA) and glutamate release. To our knowledge, no evidence indicates any role for VTA D1 dopamine receptors in regular chow intake.
Methods: In this paper, different dose of SKF38393, a D1 receptor agonist, was microinjected in VTA of 18-h food deprived-conscious rats and food intake was measured.
Results: Our results revealed that VTAmicroinjected SKF383993 increased regular chow intake in a dose-dependent manner. The SKF3833 stimulatory effect persisted over 2 h post-injection. The results showed that the SKF38393, at doses less than 5 μg, did not affect locomotor activities.
Conclusion: VTA D1-like and/or serotonergic receptors may be involved in regulatory pathways. the current study suggests that VTA D1-like and/or serotonergic receptors not only affects food reward but is also involved in regulatory mechanisms of regular feeding.
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● The ventral tegmental area participates in the control of regular feeding.
● Microinjection of SKF38393 in the ventral tegmental area increases regular food intake.
● Ventral tegmental area D1-like and or serotonergic receptors may be involved in regulatory pathways.
Plain Language Summary
The Ventral Tegmental Area (VTA) has an essential role in food reward. For the first time, we showed that SKF38393 (a D1-like dopamine or serotonergic receptors agonist) increases regular food intake in a dose-dependent manner. Also, it does not affect locomotor activities. Our results suggest that VTA dopaminergic or serotonergic pathways may be involved in the homeostatic regulation of food intake. Based on the present findings, it is essential to understand the VTA mechanisms involved in regular food intake and its possible use in treating eating disorders.
Type of Study:
Original |
Subject:
Behavioral Neuroscience Received: 2019/11/24 | Accepted: 2020/01/26 | Published: 2020/11/1