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Formulation and Antibacterial Activity of Ceremai (Phyllathus acidus) Lozenges Using Three Different Binders
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| Author:
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SETYO NURWAINI, RATNA YULIANI, WARDATUL JANNAH, AWALIA SINAKA, DEVI UTAMI YULISTYANTI
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| Abstract:
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Ceremai (Phyllathus acidus) is a traditional medicinal plant used for treating canker sores (recurrent aphthous
stomatitis). Staphylococcus aureus is one of the bacteria’s that mostly causes of canker sores. Lozenges is a
suitable dosage form for recurrent aphthous stomatitis medicine. This study aims to determine influence of
concentration of amylum manihot, gelatin, and sodium carboxymethyl cellulose as binder on physical
properties of lozenges of ceremai leaf extract, and determine antibacterial activity against Staphylococcus aureus.
Ceremai leaf was extracted by maceration using ethanol 70%. Lozenges were made by various concentrations
of binders in four formulas each. Antibacterial activity of ceremai lozenges against Staphylococcus aureus was
tested using diffusion method. Results showed that all formulas have good physical properties of lozenges. The
increase of concentration of binder produced the higher hardness, the lower friability and the longer time of
dissolution. Ceremai lozenges also inhibit potentially the growth of Staphylococcus aureus.
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| Keyword:
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ceremai, lozenges, binder, antibacterial activity
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.109
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| Download:
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