Antidepressant-Like Effect of 1α-Hydroxyvitamin D3 on Mice in the Forced Swimming Test

Akihiko KAWAURA; Yoshihisa KITAMURA; Noritoshi TANIDA; Junichi AKIYAMA; Masatoshi MIZUTANI; Kazuhiro HARADA; Motoyoshi MORISHITA; Shigeki INOUE; Yoshio KANO; Toshio OKANO; Eiji TAKEDA

doi:10.3177/jnsv.63.81

Note

Antidepressant-Like Effect of 1α-Hydroxyvitamin D₃ on Mice in the Forced Swimming Test

Akihiko KAWAURA, Yoshihisa KITAMURA, Noritoshi TANIDA, Junichi AKIYAMA, Masatoshi MIZUTANI, Kazuhiro HARADA, Motoyoshi MORISHITA, Shigeki INOUE, Yoshio KANO, Toshio OKANO, Eiji TAKEDA

Author information

Akihiko KAWAURA
Department of Physical Therapy, School of Health Care and Social Welfare, KIBI International University
Yoshihisa KITAMURA
Department of Pharmacy, Okayama University Hospital
Noritoshi TANIDA
Clinic Nishimura
Junichi AKIYAMA
Department of Physical Therapy, School of Health Care and Social Welfare, KIBI International University
Masatoshi MIZUTANI
Department of Physical Therapy, School of Health Care and Social Welfare, KIBI International University
Kazuhiro HARADA
Department of Physical Therapy, School of Health Care and Social Welfare, KIBI International University
Motoyoshi MORISHITA
Department of Physical Therapy, School of Health Care and Social Welfare, KIBI International University
Shigeki INOUE
Department of Physical Therapy, School of Health Care and Social Welfare, KIBI International University
Yoshio KANO
Department of Physical Therapy, School of Health Care and Social Welfare, KIBI International University
Toshio OKANO
Kobe Pharmaceutical University
Eiji TAKEDA
Tokushima Kenshokai College of Health and Welfare

Keywords: 1α-hydroxyvitamin D₃, forced swimming test, glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor

JOURNAL FREE ACCESS

2017 Volume 63 Issue 1 Pages 81-84

DOI https://doi.org/10.3177/jnsv.63.81

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Abstract

We examined the effect of 1α-hydroxyvitamin D₃ [1α(OH)D₃] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D₃ reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D₃ had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D₃ may have antidepressant-like activity.

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