einstein (São Paulo). 22/May/2019;17(3):eAO4399.
Lipid profile and statin use in critical care setting: implications for kidney outcome
Isabelle Malbouisson
, Beata Marie Quinto
, Marcelino de Souza Durão Junior
, Júlio Cesar Martins Monte
, Oscar Fernando Pavão dos Santos
, Roberto Camargo Narciso
, Maria Aparecida Dalboni
, Marcelo Costa Batista
DOI: 10.31744/einstein_journal/2019AO4399
ABSTRACT
Objective:
To determine whether pre-hospital statin use is associated with lower renal replacement therapy requirement and/or death during intensive care unit stay.
Methods:
Prospective cohort analysis. We analyzed 670 patients consecutively admitted to the intensive care unit of an academic tertiary-care hospital. Patients with ages ranging from 18 to 80 years admitted to the intensive care unit within the last 48 hours were included in the study.
Results:
Mean age was 66±16.1 years old, mean body mass index 26.6±4/9kg/m2 and mean abdominal circumference was of 97±22cm. The statin group comprised 18.2% of patients and had lower renal replacement therapy requirement and/or mortality (OR: 0.41; 95%CI: 0.18-0.93; p=0.03). The statin group also had lower risk of developing sepsis during intensive care unit stay (OR: 0.42; 95%CI: 0.22-0.77; p=0.006) and had a reduction in hospital length-of-stay (14.7±17.5 days versus 22.3±48 days; p=0.006). Statin therapy was associated with a protective role in critical care setting independently of confounding variables, such as gender, age, C-reactive protein, need of mechanical ventilation, use of pressor agents and presence of diabetes and/or coronary disease.
Conclusion:
Statin therapy prior to hospital admission was associated with lower mortality, lower renal replacement therapy requirement and sepsis rates.
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