Coffee is the most popular drink in the world and coffee intake may be a risk factor for gastroesophageal reflux disease (GERD), which is a common disorder and its worldwide prevalence is increasing. However, the effect of coffee on GERD remains to be fully elucidated. The relationship between GERD and coffee consumption is not clear given the existing literature, whose results are diverse and contradictory. Existing systematic investigations are not adequate and further well-designed prospective studies are needed to clarify the effect of coffee on GERD.