Abstract
Thorough investigation and comparative study were conducted for insulin-loaded microparticles fabricated by consecutive adsorption of polyanions (dextran sulfate and chitosan sulfate) and polycations (chitosan and protamine) onto protein microaggregates. The possible regulation of insulin release from the particles by variation in polyelectrolyte pairs, in the number of their adsorption cycles and in pH of media was demonstrated. For all studied cases the microparticles showed protective action towards insulin inactivation at acid pH values and protein release at pH > 5, corresponding to human gastro-intestinal conditions.
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Original Russian Text © N.G. Balabushevich, G.A. Vikhoreva, E.V. Mikhal’chik, N.I. Larionova, 2010, published in Vestnik Moskovskogo Universiteta. Khimiya, 2010, No. 3, pp. 178–184.
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Balabushevich, N.G., Vikhoreva, G.A., Mikhal’chik, E.V. et al. Fabrication and properties of pH-sensitive nanostructured polyelectrolyte microparticles loaded with insulin. Moscow Univ. Chem. Bull. 65, 148–153 (2010). https://doi.org/10.3103/S0027131410030089
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DOI: https://doi.org/10.3103/S0027131410030089