Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol

Authors

Rosa Maria Bruno^{1, *,} , Bart Spronck^{2, 3,} , Bernhard Hametner^4, , Alun Hughes^5, , Patrick Lacolley^6, , Christopher C. Mayer^4, , Maria Lorenza Muiesan^7, , Chakravarthi Rajkumar^8, , Dimitrios Terentes-Printzios^9, , Thomas Weber^10, , Tine Willum Hansen^11, , Pierre Boutouyrie^1, , on behalf of the ARTERY Society

¹INSERM U970 Team 7, Paris Cardiovascular Research Centre - PARCC, University Paris Descartes, AP-HP, Pharmacology Unit, Hôpital Européen Georges Pompidou, 56 Rue Leblanc, Paris 75015, France

²Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands

³Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, CT, USA

⁴Center for Health & Bioresources, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Vienna, Austria

⁵MRC unit for Lifelong Health and Ageing, Institute of Cardiovascular Science, University College London, UK

⁶Faculty of Medicine, Lorraine University, Inserm, DCAC, Nancy, France

⁷Department of Clinical & Experimental Sciences, University, of Brescia-Medicina 2, ASST Spedali Civili Brescia, Brescia, Italy

⁸Department of Medicine, Brighton & Sussex Medical School, Brighton, UK

⁹First Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece

¹⁰Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria

¹¹Steno Diabetes Center Copenhagen, Clinical Research Department, Denmark

^*Corresponding author. Email: rosa-maria.bruno@inserm.fr

DOI

10.2991/artres.k.201124.001How to use a DOI?

Keywords

COVID-19; coronavirus; inflammation; vascular ageing; arterial stiffness

Abstract

In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study — the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable.

Copyright

© 2020 The Authors. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Bart Spronck
AU  - Bernhard Hametner
AU  - Alun Hughes
AU  - Patrick Lacolley
AU  - Christopher C. Mayer
AU  - Maria Lorenza Muiesan
AU  - Chakravarthi Rajkumar
AU  - Dimitrios Terentes-Printzios
AU  - Thomas Weber
AU  - Tine Willum Hansen
AU  - Pierre Boutouyrie
AU  - on behalf of the ARTERY Society
PY  - 2020
DA  - 2020/12/08
TI  - Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol
JO  - Artery Research
SP  - 59
EP  - 68
VL  - 27
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201124.001
DO  - 10.2991/artres.k.201124.001
ID  - Bruno2020
ER  -