肝臓
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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慢性肝炎における肝線維化マーカーELFスコアの有用性
高嶋 智之飯島 尋子青木 智子中野 智景會澤 信弘岸野 恭平霜野 良弘長谷川 国大高田 亮楊 和典石井 昭生坂井 良行西村 貴士西川 浩樹岩田 恵典池田 直人榎本 平之廣田 誠一藤元 治朗矢野 博久中島 収鹿毛 政義西口 修平
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ジャーナル フリー

2015 年 56 巻 10 号 p. 543-545

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We evaluated the usefulness of the enhanced liver fibrosis panel (ELF, ADVIA Centaur®), the new method to assess liver fibrosis using serum fibrosis markers in patients with chronic hepatitis, and compared the result with other serological fibrosis markers. 338 patients with chronic hepatitis were included. ELF score, which consists of hyaluronic acid, procollagen type III propeptide (PIIIP) and tissue inhibitor of matrix metalloproteinase -1 (TIMP-1) was F0; 8.6±1.0, F1; 9.0±0.9, F2; 9.9±1.3, F3; 10.8±1.1, F4; 11.3±0.9, and increased with the development of fibrosis. The area under the receiver operating characteristic curve (AUROC) for the diagnosis of liver cirrhosis was 0.867 and showed good diagnostic accuracy (p<0.001). The ELF score is a useful noninvasive tool for the diagnosis of liver fibrosis stage in patients with chronic hepatitis.

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© 2015 一般社団法人 日本肝臓学会
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