Filippov M. M., Ilyin V. N., Portnichenko V. I., Lukyantseva G. V.

SYSTEM CHANGES IN THE ORGANISM OF ATHLETES, INFLUENCING THE MASS TRANSFER OF RESPIRATORY GAS IN MUSCLE ACTIVITY IN MOUNTAINS


About the author:

Filippov M. M., Ilyin V. N., Portnichenko V. I., Lukyantseva G. V.

Heading:

LITERATURE REVIEWS

Type of article:

Scentific article

Annotation:

For the physiology of sports and the theory of hypoxic states, it is important to find out the mechanisms that provide the process of mass transfer and oxygen utilization in the muscular activity of various intensities in conditions of reduced pO2 in the inhaled air, especially the satisfaction of the increased oxygen demand of the organism. The decrease in pO2 in inhaled air is known to limit the ability to increase oxygen consumption and capacity for work. Certain efficiency of mountain training of athletes, as a means of increasing the functionality and endurance, is proved in numerous works of specialists in the field of sports physiology. However, despite this, interest in the problem of training athletes in mountain conditions remains high enough. The article provides an overview of the current literature on the peculiarities of the influence of mountain hypoxia, as well as hypoxia of stress on the mass transfer of respiratory gases – oxygen and carbon dioxide. The basic mechanisms of the functioning of the constituent elements of the oxygen transport system (respiratory systems, blood and blood circulation) under conditions of muscle training activity in the mountains are considered. The features of changes in the main factors that most limit the maximum oxygen consumption and the associated level of performance of athletes are given. The review analyzes typical adaptation shifts aimed at economizing the activity of the entire transport system and oxygen utilization in the body when performing physical work, which contribute to an increase in working capacity and a rapid course of recovery processes. Among them are changes in the functioning of the respiratory system, optimization of hemodynamic parameters, growth of indicators of the eritron system, as well as the restructuring of the main systems of muscle energy supply, and the like. In this review, we did not set ourselves the task of detecting the effect of the maximum reduction of pO2 on the process of phased delivery and disposal of oxygen, the formation and removal of CO2 from the body. This article is only an attempt to analyze changes in these processes in muscle activity at those heights in the mountains, where the training of athletes is most fully carried out.

Tags:

hypoxia, maximum oxygen consumption, pO2 , training in the mountains.

Bibliography:

  1. Rovnyi AS, Ilin VM, Lizohub VS, Rovna OO. Fiziolohiia sportyvnoi diialnosti. X.: KhNADU; 2015. 556 s. [in Russian].
  2. Liabakh EH, Mankovskaia YN. Snabzhenye kyslorodom myshts cheloveka pry rabote v horakh. Sportyvnaia medytsyna. 2008;1:120-6. [in Russian].
  3. Bulatova MM, Platonov VN. Srednehore, vysokohore y yskusstvennaia hypoksyia v systeme podhotovky sportsmenov. Sportyvnaia medytsyna. 2008;1:95-120. [in Russian].
  4. Balykyn MV, Karkobatov KhD, Fylyppov MM. Morfofunktsyonalnye yzmenenyia v orhanakh pry fyzycheskoi nahruzke v horakh. V kn.: Nauchn. trudy III s’ezda fyzyolohov SNH (Ialta, Ukrayna, 1-6 okt. 2011 h.), Moskva-Yalta: Medytsyna-Zdorove; 2011. s. 146. [in Russian].
  5. Wilhite DP, Mickleborough TD, Laymon AS. Increases in VO2 max with “live high-train low” altitude training: role of ventilatory acclimatization. Eur J ApplPhysiol, 2013 February 20;113(2):419-26.
  6. Brocherie F, Girard O, Fais R, Millet GP. Altitud y deportes de equipo: métodos tradicionales desafiados por un entrenamiento innovador y específico en hipoxia. Revista internacional de ciencias del deporte. 2016;46(12):338-58. Available from: dx.doi.org/10.5232/ ricyde2016.04601
  7. Pottgiesser T, Ahlgrim C, Ruthardt S, Dickhuth HH, Schumacher YO. Hemoglobin mass after 21 days of conventional altitude training at 1816m. J Sci Med Sport. 2009 Nov;12(6):673-5. DOI: 10.1016/j.jsams.2008.06.005
  8. Heinicke K, Heinicke I, Schmidt W, Wolfarth B. A three-week traditionalaltitude training increases hemoglobin mass and red cell volume in elitebiathlon athletes. Int J Sports Med. 2005 Jun;26(5):350-5.
  9.  Wehrlin JP, Zuest P, Hallén J, Marti B. Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes. J J Appl Physiol. 2006 Jun;100(6):1938-45.
  10. Gough CE, Saunders PU, Fowlie J, Savage B, Pyne DB, Anson JM, еt al. Influence of altitude training modality on performance and total haemoglobin mass in elite swimmers. Eur J Appl Physiol. 2012 Sep;112(9):3275-85. DOI: 10.1007/s00421-011-2291-7
  11. Sinex JA, Chapman RF. Hypoxic training methods for improving endurance exercise performance. Journal of Sport and Health Science, 2015 December 21;4(4):325-32. Available from: doi.org/10.1016/j.jshs.2015.07.005
  12. Wiggins CC, Constantini K, Paris HL, Mickleborough TD, Chapman RF. Ischemic Preconditioning, O2 Kinetics, and Performance in Normoxia and Hypoxia. Med Sci Sports Exerc. 2019 May;51(5):900-11. DOI: 10.1249/MSS.0000000000001882
  13. Ziuzkov HN, Dyhai AM, Holdberh ED. Humoralnye mekhanyzmy rehuliatsyy erytropoeza pry hypoksyy. Biul. eksper. byol. y medytsyny. 2005;139(2):133-7. [in Russian].
  14. Faiss R, Leger B, Vesin J, Fournier PE, Eggel Y, Deriaz O, еt al. Significant molecular and systemic adaptations after repeated sprint training in hypoxia. PLoS One. 2013 February 20;8:e56522. Available from: doi.org/10.1371/journal.pone.0056522
  15. Faiss R, Pialoux V, Sartori C, Faes C, Deriaz O, Millet GP. Ventilation, Oxidative Stress and Nitric Oxide in Hypobaric vs. Normobaric Hypoxia. Med Sci Sports Exerc. 2013 Feb;45(2):253-60. DOI: 10.1249/MSS.0b013e31826d5aa2
  16. Riamova KA, Rozenfeld AS. Osobennosty dykhanyia mytokhondryi pry hypoksyy y atsydoze. Chelovek. Sport. Medytsyna. 2008;16:31- 5. [in Russian].
  17. Balykyn MV, Karkobatov KhD. Systemnye y orhannye mekhanyzmy kyslorodnoho obespechenyia orhanyzma v uslovyiakh vysokohoria. Rossyiskyi fyzyolohycheskyi zhurnal ym. Y.M.Sechenova. 2012;98(1):127-36. [in Russian].
  18. Portnychenko VY, Ylyn VN, Fylyppov MM. Proiavlenye hypometabolycheskoho еffekta v reaktsyiakh systemy dykhanyia u sportsmenov na fyzycheskuiu nahruzku pry adaptatsyy v srednehoria. Ulianovskyi medyko-byolohycheskyi zhurnal. 2017;2:116-23. [in Russian].
  19. Chatterjee T, Bhattacharyya D, Pramanik A, Pal M, Majumdar D, Majumdar D. Soldiers load carriage performance in high mountains: a physiological study. Mil Med Res. 2017 Feb 17;4:6. DOI: 10.1186/s40779-017-0113-x
  20. Shpak TV, Kiriienko MP. Pidhotovka velosypedystiv vysokoi kvalifikatsii v umovakh serednohiria. Sportyvnaia medytsyna. 2008;1:137- 42. [in Ukrainian].
  21. Rodríguez FA, Iglesias X, Feriche B, Calderón-Soto C, Chaverri D, Wachsmuth NB, et al. Altitude training in elite swimmers for sea level performance (altitude project). Med Sci Sports Exerc. 2015 Sep;47(9):1965-78. DOI: 10.1249/MSS.0000000000000626
  22. Wilber RL. Application of altitude/hypoxic training by elite athletes. Med Sci Sports Exerc. 2007 Sep;39(9):1610-24.
  23. Aughey RJ, Buchheit M, Garvican-Lewis LA, Roach GD, Sargent C, Billaut F, et al. Yin and yang, or peas in a pod? Individual-sport versus team-sport athletes and altitude training. Br J Sports Med. 2013 Dec;47(18):1150-4. DOI: 10.1136/bjsports-2013-092764
  24. Andrade DC, Beltrán AR, Labarca-Valenzuela C, Manzo-Botarelli O, Trujillo E, Otero-Farias P, еt al. Effects of Plyometric Training on Explosive and Endurance Performance at Sea Level and at High Altitude. Front Physiol. 2018;9:1415. DOI: 10.3389/fphys.2018.01415
  25. Brooks GA. Current concepts in lactate exchange. Med Sci Sports Exerc. 1991 Aug;23(8):895-906.
  26. Fanelli C, Calderone S, Epifano C, De Vincenzo A, Modarelli F, Pampanelli S, et al. Demonstration of a critical role for free fatty acids in mediating counter regulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J Clin Invest. 1993 Oct;92(4):1617-22.
  27. Robergs R, Landwehr R. The surprising history of the “hrmax=220-age equation. JEPonline. 2002;5(2):1-10.
  28. Loeppky JA, Sheard AC, Salgado RM, Mermier CM. VE STPD as a measure of ventilatory acclimatization to hypobaric hypoxia. Physiol Int. 2016 Sep;103(3):377-91. DOI: 10.1556/2060.103.2016.3.1
  29. Ebine N, Aoki T, Itoh M, Fukuoka Y. Differential kinetics of the cardiac, ventilatory, and gas exchange variables during walking under moderate hypoxia. PLoS One. 2018 Jul 25;13(7):e0200186. DOI: 10.1371/journal.pone.0200186
  30. Bohush VL, Reznychenko OY, Kuvaldyna OV, Yatsunskyi EA, Veselova YN, Faryonov VN. Yzmenenye aerobnykh vozmozhnostei orhanyzma pry trenyrovke v srednehore. Aktualni problemy fizychnoho vykhovannia i sportu v suchasnykh umovakh: materialy I Mizhnarodnoi naukovo-praktychnoi konfrentsii, Dnipropetrovsk. 2015;1:32-6. [in Russian].
  31. Shesterova L, Yankhao Tu. Dynamyka byokhymycheskykh y fyzyolohycheskykh pokazatelei behunov na srednye dystantsyy pod vlyianyem trenyrovky v hornykh uslovyiakh. Nauk. chasopys Natsionalnoho ped. universytetu imeni M. P. Drahomanova. 2017;7(89):44- 50. [in Russian].
  32. Ysaev AP, Potapova TV, Romanov YuN. Sovremennye problemy vydov sporta, razvyvaiushchykh spetsyalnuiu vynoslyvost. Vestnyk YuUrHU. 2010;6(22):6-14. [in Russian].
  33. Faoro V, Huez S, Vanderpool R, Groepenhoff H, de Bisschop C, Martinot JB, еt al. Pulmonary circulation and gas exchange at exercise in Sherpas at high altitude. J Appl Physiol. (1985). 2014 Apr 1;116(7):919-26. DOI: 10.1152/japplphysiol.00236.2013
  34. Esposito F, Ferretti G. Respiratory muscle training and maximum aerobic power in hypoxia. Eur J Appl Physiol. 2010 Sep;110(1):219- 20. DOI: 10.1007/s00421-010-1487-6
  35. Beretta E, Lanfranconi F, Grasso GS, Bartesaghi M, Alemayehu HK, Pratali L, еt al. Air blood barrier phenotype correlates with alveolocapillary O2 equilibration in hypobaric hypoxia. Respir Physiol Neurobiol. 2017 Dec;246:53-8. DOI: 10.1016/j.resp.2017.08.006
  36. Berezovskyi VA. Pryrodnaia y ynstrumentalnaia oroterapyia. Donetsk: Yzd. Zaslavskyi O.Iu.; 2012. 304 s. [in Russian].
  37. Miasnykova EF, Holovykhyn EV, Zoryna TB. Prymenenye metodov yntervalnoi hyperkopnycheskoi hypoksycheskoi trenyrovky v atsyklycheskykh vydakh sporta. Uchenye zapysky unyversyteta ym. P.F. Leshafta. 2009;2(48):59-64. [in Russian].
  38. Hun-Young P, Chulho S, Kiwon L. Intermittent hypoxic training for 6 weeks in 3000 m hypobaric hypoxia conditions enhances exercise economy and aerobic exercise performance in moderately trained swimmers. Biol Sport. 2018 Mar;35(1):49-56.
  39. Ilyin VN, Filippov MM, Pastukhovа VA, Sosnovskiy VV. Training of the athletes with use of hypoxic conditions. Visnyk Cherkaskoho universytetu. 2017;2:11-26.
  40. Holliss BA, Fulford J, Vanhatalo А, Pedlar CR, Jones АМ. Influence of intermittent hypoxic training on muscle energetics and exercise tolerance. J Appl Physiol. 2013 Mar 1;114(5):611-9. DOI: 10.1152/japplphysiol.01331.2012
  41. Suslyna YV. Fyzyolohycheskye osnovy vynoslyvosty v sporte. Lytres, 2017. 381 s. [in Russian].
  42. Hryshyn OV, Basalaeva SV, Umantseva ND, Ustiuzhanynova NV, Hryshyn VH, Mytrofanov YM. Uvelychenye skorosty vydelenyia SO2 v pokoe pry kratkovremennoi hypoksyy u zdorovykh liudei. Fyzyolohyia cheloveka. 2011;37(5):77-83. [in Russian].
  43. Cao Y, Ichikawa Y, Sasaki Y, Ogawa T, Hiroyama T, Enomoto Y, еt al. Expiratory flow limitation under moderate hypobaric hypoxia does not influence ventilatory responses during incremental running in endurance runners. Physiol Rep. 2019 Mar 28;7(3):e13996. DOI: 10.14814/phy2.13996
  44. Katayama K, Goto K, Ohya T, Iwamoto E, Takao K, Kasai N, еt al. Effects of Respiratory Muscle Endurance Training in Hypoxia on Running Performance. Med Sci Sports Exerc. 2019 Feb 15. DOI: 10.1249/MSS.0000000000001929
  45. Álvarez-Herms J, Julià-Sánchez S, Corbi F, Odriozola-Martínez A, Burtscher M. Putative Role of Respiratory Muscle Training to Improve Endurance Performance in Hypoxia: A Review. Front Physiol. 2019 January 15;9:1970. DOI: 10.3389/fphys.2018.01970
  46. Bocharov NY. Reaktsyia hemodynamyky cheloveka na raznye po velychyne hypoksycheskye vozdeistvyia. Ulianovskyi medykobyolohycheskyi zhurnal. 2012;3:138-45. [in Russian].
  47. Sharma AP, Saunders PU, Garvican-Lewis LA, Périard JD, Clark B, Gore CJ, еt al. Training Quantification and Periodization during Live High Train High at 2100 M in Elite Runners: An Observational Cohort Case Study. J Sports Sci Med. 2018 Nov 20;17(4):607-16.
  48. Bellafiore M, Battaglia G, Bianco A, Palma A. Expression Pattern of Angiogenic Factors in Healthy Heart in Response to Physical Exercise Intensity. 2019;10:238. DOI: 10.3389/fphys.2019.00238
  49. Siebenmann C, Ryrsо CK, Oberholzer L, Fisher JP, Hilsted LM, Rasmussen P, еt al. Hypoxia-induced vagal withdrawal is independent of the hypoxic ventilatory response in men. J Appl Physiol. 2019 Jan 1;126(1):124-31. DOI: 10.1152/japplphysiol.00701.2018
  50. Lizamore CA, Hamlin MJ. The Use of Simulated Altitude Techniques for Beneficial Cardiovascular Health Outcomes in Nonathletic, Sedentary, and Clinical Populations: A Literature Review. High Alt Med Biol. 2017 Dec;18(4):305-21. DOI: 10.1089/ham.2017.0050
  51. Yordanskaia FA. Funktsyonalnaia podhotovlennost voleibolystov. Dyahnostyka, mekhanyzmy adaptatsyy, korrektsyia symptomov dyzaptatsyy. M.: Sport; 2016. 176 s. [in Russian].
  52. Yordanskaia FA, Buchyna EV, Kochetkova NY, Tsepkova NK, Nyrka VV. Kompleksnyi medyko-byolohycheskyi kontrol v pliazhnom voleibole. M.: Sport; 2018. 96 s. [in Russian].
  53. La Padula PH, Etchegoyen M, Czerniczyniec A, Piotrkowski B, Arnaiz SL, Milei J, Costa LE. Cardioprotection after acute exposure to simulated high altitude in rats. Role of nitric oxide. Nitric Oxide. 2018 Feb 28;73:52-9. DOI: 10.1016/j.niox.2017.12.007
  54. Liang YH, Shen YQ, Guo W, Zhu YZ. SPRC protects hypoxia and re-oxygenation injury by improving rat cardiac contractile function and intracellular calcium handling. Nitric Oxide. 2014 Sep 15;41:113-9. DOI: 10.1016/j.niox.2014.05.010
  55. Gatterer H, Menz V, Salazar-Martinez E, Sumbalova Z, Garcia-Souza LF, Velika B, еt al. Exercise Performance, Muscle Oxygen Extraction and Blood Cell Mitochondrial Respiration after Repeated-Sprint and Sprint Interval Training in Hypoxia. A Pilot Study. J Sports Sci Med. 2018 Aug 14;17(3):339-47.
  56. Keramidas ME, Debevec T, Amon M, Kounalakis SN, Simunic B, Mekjavic IB. Respiratory muscle endurance training: effect on normoxic and hypoxic exercise performance. Eur J Appl Physiol. 2010 Mar;108(4):759-69. DOI: 10.1007/s00421-009-1286-0

Publication of the article:

«Bulletin of problems biology and medicine» Issue 2 Part 2 (151), 2019 year, 64-71 pages, index UDK 616.2:612.017

DOI: