Research Article


DOI :10.26650/IstanbulJPharm.2018.18007   IUP :10.26650/IstanbulJPharm.2018.18007    Full Text (PDF)

Synthesis, Characterization and Biological Activity Studies on Amide Derivatives

Sevda TürkKadir TuranSeyhan UlusoySevgi KarakuşGülgün Boşgelmez Tınaz

In this study, with intent to find out novel anti-biofilm and antiviral agents, a series of amide derivatives were synthesized and their structures were elucidated by FT-IR and 1H-NMR and 13C-NMR and MS methods. And also, their purity were proven by TLC, HPLC and elemental analyses. And finally, the synthesized compounds were examined for their biofilm formation and swarming motility inhibitory activities in P. aeruginosa PA01. These compounds were found to reduce biofilm formation by 8.7-25.6% and swarming motility by 18.3-33.8% in P. aeruginosa PA01 at a concentration of 200 µM. Besides, all of the compounds were evaluated for their antiviral activity against influenza A viruses. The plaque inhibition assays indicated that compound 6 (N-(4-{[5-(ethylamino)-1,3,4-thiadiazol-2-yl]methyl}phenyl)-4- fluorobenzamide) has considerable inhibitory effect on influenza A virus plaque formation.


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APA

Türk, S., Turan, K., Ulusoy, S., Karakuş, S., & Boşgelmez Tınaz, G. (2018). Synthesis, Characterization and Biological Activity Studies on Amide Derivatives. İstanbul Journal of Pharmacy, 48(3), 76-81. https://doi.org/10.26650/IstanbulJPharm.2018.18007


AMA

Türk S, Turan K, Ulusoy S, Karakuş S, Boşgelmez Tınaz G. Synthesis, Characterization and Biological Activity Studies on Amide Derivatives. İstanbul Journal of Pharmacy. 2018;48(3):76-81. https://doi.org/10.26650/IstanbulJPharm.2018.18007


ABNT

Türk, S.; Turan, K.; Ulusoy, S.; Karakuş, S.; Boşgelmez Tınaz, G. Synthesis, Characterization and Biological Activity Studies on Amide Derivatives. İstanbul Journal of Pharmacy, [Publisher Location], v. 48, n. 3, p. 76-81, 2018.


Chicago: Author-Date Style

Türk, Sevda, and Kadir Turan and Seyhan Ulusoy and Sevgi Karakuş and Gülgün Boşgelmez Tınaz. 2018. “Synthesis, Characterization and Biological Activity Studies on Amide Derivatives.” İstanbul Journal of Pharmacy 48, no. 3: 76-81. https://doi.org/10.26650/IstanbulJPharm.2018.18007


Chicago: Humanities Style

Türk, Sevda, and Kadir Turan and Seyhan Ulusoy and Sevgi Karakuş and Gülgün Boşgelmez Tınaz. Synthesis, Characterization and Biological Activity Studies on Amide Derivatives.” İstanbul Journal of Pharmacy 48, no. 3 (Apr. 2024): 76-81. https://doi.org/10.26650/IstanbulJPharm.2018.18007


Harvard: Australian Style

Türk, S & Turan, K & Ulusoy, S & Karakuş, S & Boşgelmez Tınaz, G 2018, 'Synthesis, Characterization and Biological Activity Studies on Amide Derivatives', İstanbul Journal of Pharmacy, vol. 48, no. 3, pp. 76-81, viewed 19 Apr. 2024, https://doi.org/10.26650/IstanbulJPharm.2018.18007


Harvard: Author-Date Style

Türk, S. and Turan, K. and Ulusoy, S. and Karakuş, S. and Boşgelmez Tınaz, G. (2018) ‘Synthesis, Characterization and Biological Activity Studies on Amide Derivatives’, İstanbul Journal of Pharmacy, 48(3), pp. 76-81. https://doi.org/10.26650/IstanbulJPharm.2018.18007 (19 Apr. 2024).


MLA

Türk, Sevda, and Kadir Turan and Seyhan Ulusoy and Sevgi Karakuş and Gülgün Boşgelmez Tınaz. Synthesis, Characterization and Biological Activity Studies on Amide Derivatives.” İstanbul Journal of Pharmacy, vol. 48, no. 3, 2018, pp. 76-81. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2018.18007


Vancouver

Türk S, Turan K, Ulusoy S, Karakuş S, Boşgelmez Tınaz G. Synthesis, Characterization and Biological Activity Studies on Amide Derivatives. İstanbul Journal of Pharmacy [Internet]. 19 Apr. 2024 [cited 19 Apr. 2024];48(3):76-81. Available from: https://doi.org/10.26650/IstanbulJPharm.2018.18007 doi: 10.26650/IstanbulJPharm.2018.18007


ISNAD

Türk, Sevda - Turan, Kadir - Ulusoy, Seyhan - Karakuş, Sevgi - Boşgelmez Tınaz, Gülgün. Synthesis, Characterization and Biological Activity Studies on Amide Derivatives”. İstanbul Journal of Pharmacy 48/3 (Apr. 2024): 76-81. https://doi.org/10.26650/IstanbulJPharm.2018.18007



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