Authors:	Zaheri, Hooman Beyzaee, Amir Mohammad Rokni, Ghasem Rahmatpour Patil, Anant Golpour, Masoud Goldust, Mohamad
Title:	Comparison of the efficacy of carboxytherapy versus fractional CO2 laser therapy for the treatment of periorbital dark circles : a randomized clinical trial
Online publication date:	25-Jan-2023
Year of first publication:	2022
Language:	english
Abstract:	Background: Periorbital dark circles (PDC) is one of the most common cosmetic issues in today's society. Only moderate degree of improvement has been achieved by vari ous available treatment options. The present study aimed to compare the clinical ef ficacy of carboxytherapy and fractional CO2 laser therapy in the management of PDC. Methods: In this split face study, 30 patients with bilateral PDC aged between 23 and 52 years were recruited who underwent carboxytherapy (n = 30) on PDC of one side of the face and fractional CO2 laser therapy (n = 30) on the PDC of other side. The entire treatment comprised of four sessions of each therapy with an interval of 2 weeks each time. The assessment was based on both subjective methods (patients' satisfaction and physician's judgment) and objective method (based on digital stand ard photographs). The degree of improvement from the patient's point of view (pa tient satisfaction) and physician's point of view (physician satisfaction) was assessed in different therapy sessions in comparison with the improvement after first session. Results: The study included 30 patients with mean age of 38.22 ± 8.3 years. The mean disease duration was 45 ± 12.3 months. After the second therapy session, patients' satisfaction was remarkably better in the fractional CO2 laser therapy group than the carboxytherapy group, over the time. According to the physician satisfaction, the im provement rate was higher after the second and sixth weeks in the fractional CO2 laser therapy group than the carboxytherapy group; whereas in other sessions, there were no statistically significant differences. There were no significant side effects observed in either group post-treatment each time. Conclusion: Fractional CO2 laser therapy is a better option to treat PDC than car boxytherapy. Also, mild side effects (including erythema, pain, and discomfort) were reported in both groups; with no significant difference between the groups.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8557
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	Biometrical journal Version of Record (VoR)
Publisher:	Wiley-VCH
Publisher place:	Berlin
Issue date:	2022
ISSN:	1473-2165
Publisher DOI:	10.1111/jocd.15337
Appears in collections:	DFG-491381577-H