Authors:	Schuster, Alexander K. Fischer, Joachim Ernst Vossmerbäumer, Urs
Title:	Central corneal thickness in spectral-domain OCT and associations with ocular and systemic parameters
Online publication date:	21-Jul-2016
Year of first publication:	2016
Language:	english
Abstract:	Background. Optical coherence tomography (OCT) allows quantitative analysis of the anterior segment of the eye with a noncontact examination. The aim of this study is to analyze associations of central corneal thickness (CCT) as measured by OCT with ocular and systemic cardiovascular parameters. Methods. A cross-sectional study of 734 persons was performed in a working age population. Only healthy eyes were included. A comprehensive ophthalmological examination including refraction, noncontact tonometry, and imaging of the anterior segment by SD-OCT was performed. In parallel, a broad range of systemic cardiovascular parameters were measured. Associations were analyzed using a generalized estimating equations' model. Results. CCT measurements showed a significant association with corneal curvature and intraocular pressure: a thinner CCT was associated with a flatter cornea and with lower intraocular pressure (p < 0.001). Age was positively associated with CCT (p < 0.001); all other cardiovascular parameters were not associated. Conclusion. A thinner cornea is associated with a flatter surface and with lower intraocular pressure readings, while there are no independent associations with refraction and systemic cardiovascular parameters. Our findings highlight the value of SD-OCT CCT measurements as a standard tool in anterior segment analysis.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-688
URN:	urn:nbn:de:hebis:77-publ-544032
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Journal of Ophthalmology 2016
Pages or article number:	Art. 2596956
Publisher:	Hindawi
Publisher place:	New York, NY
Issue date:	2016
ISSN:	2090-004X
Publisher URL:	http://dx.doi.org/10.1155/2016/2596956
Publisher DOI:	10.1155/2016/2596956
Appears in collections:	JGU-Publikationen