ORIGINAL ARTICLE   

Giornale Italiano di Dermatologia e Venereologia 2018 October;153(5):619-23

DOI: 10.23736/S0392-0488.17.05488-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Vitiligo susceptibility and catalase gene polymorphisms in Sicilian population

Valentina CAPUTO ¹ ✉, Marcello NICETA ², Santi FIORELLA ¹, Marco LA VECCHIA ¹, Emanuela BASTONINI ³, Maria R. BONGIORNO ¹, Giuseppe PISTONE ¹

¹ Department of Dermatology, University of Palermo, Palermo, Italy; ² Laboratory of Molecular Genetics, Villa Sofia V. Cervello Hospital, Palermo, Italy; ³ Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics, San Gallicano Dermatologic Institute (IRCCS), Rome, Italy

BACKGROUND: Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in vitiligo patients. Catalase is a well-known oxidative stress regulator that could play an important role in the pathogenesis of vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with vitiligo susceptibility in Sicilian population.
METHODS: Sixty out of 73 Sicilian patients with vitiligo were enrolled and submitted to CAT gene analysis.
RESULTS: Contrary to the Northern part of Europe but likewise to the Mediterranean area, the frequency of the CAT genotypes in Sicily is equally distributed. Out of all CAT genotypes, only CAT-89 T/T frequency was found to be significantly higher amongst vitiligo patients than controls.
CONCLUSIONS: Despite the involvement of the CAT enzyme in the pathogenesis of vitiligo, the biological significance of CAT gene polymorphisms is still controversial. With the only exception for CAT variant -89A/T, the other studied CAT gene polymorphisms (389C/T and 419C/T) might not to be associated with vitiligo in Sicilian population.

KEY WORDS: Catalase - Genetic predisposition to disease - Oxidative stress - Vitiligo