Decreased Expression of Semaphorin-3A, a Neurite-Collapsing Factor, is Associated With Itch in Psoriatic Skin
DOI:
https://doi.org/10.2340/00015555-1350Keywords:
psoriasis, pruritus, C-fibre, nerve growth factor, sema�phorin-3A, neuropilin-1, NGF, Sema3AAbstract
Pruritus is a common symptom of psoriasis, which affects quality of life. This symptom accompanies the hyper-innervation of sensory C-fibres in psoriatic lesions. Two extracellular molecules, nerve growth factor (NGF) and semaphorin-3A, regulate C-fibre extension. In this study, the expression levels of these 2 molecules in biopsy specimens from psoriatic and healthy skin were quantified by immunohistochemistry and quantitative reverse-transcription PCR. Semaphorin-3A expression was lower in the psoriatic samples compared with the healthy samples, whereas NGF was higher. C-fibre innervation in the epidermis was also increased in psoriatic skin. Semaphorin-3A mRNA expression was negatively correlated with itch intensity and severity of psoriasis. We propose that decreased semaphorin-3A and increased NGF expression levels may trigger the outgrowth of C-fibres, leading to pruritus.Downloads
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Copyright (c) 2012 Kenzen Kou, Fumio Nakamura, Michiko Aihara, Huichin Chen, Katsuya Seto, Junko Komori-Yamaguchi, Takeshi Kambara, Yoji Nagashima, Yoshio Goshima, Zenro Ikezawa
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