The aim of the present study is to evaluate the wear resistance and microhardness of various interim fixed prosthesis materials with different chemical compositions and curing methods. One heat-cured and four self-cured acrylic resins, and three self-cured, one light-cured, and one dual-cured composite-based materials were tested. For microhardness, samples from each group were tested after storing either at 37°C in artificial saliva for 7 days, followed by thermocycling, or in distilled water solution at 37°C for 24 h. For the evaluation of wear, the remaining samples were evaluated using a 3D scanner and a surface analysis program before loading in the chewing simulator and after every 10,000 cycles. There was a significant difference in wear behavior among the materials tested at both 10,000 and 20,000 cycles (P < 0.001). Microhardness and wear resistance were significantly different between acrylic and composite materials.