Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008

Yoshihiro Watanabe; Yurika Yoshida; Toshiyuki Tokiwa; Mayuka Higo; Sayaka Ban; Akari Ikeda; Yoshihiko Noguchi; Tomoyasu Hirose; Toshiaki Sunazuka; Kenichi Nonaka; Takashi Yaguchi; Masato Iwatsuki

doi:10.2323/jgam.2022.03.002

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Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008

Yoshihiro Watanabe, Yurika Yoshida, Toshiyuki Tokiwa, Mayuka Higo, Sayaka Ban, Akari Ikeda, Yoshihiko Noguchi, Tomoyasu Hirose, Toshiaki Sunazuka, Kenichi Nonaka, Takashi Yaguchi, Masato Iwatsuki

Author information

Yoshihiro Watanabe
Ōmura Satoshi Memorial Institute, Kitasato University
Graduate School of Infection Control Sciences, Kitasato University
Yurika Yoshida
School of Science, Kitasato University
Toshiyuki Tokiwa
Ōmura Satoshi Memorial Institute, Kitasato University
Mayuka Higo
Ōmura Satoshi Memorial Institute, Kitasato University
Graduate School of Infection Control Sciences, Kitasato University
Sayaka Ban
Medical Mycology Research Center, Chiba University
Akari Ikeda
Ōmura Satoshi Memorial Institute, Kitasato University
Graduate School of Infection Control Sciences, Kitasato University
Yoshihiko Noguchi
Ōmura Satoshi Memorial Institute, Kitasato University
Graduate School of Infection Control Sciences, Kitasato University
Tomoyasu Hirose
Ōmura Satoshi Memorial Institute, Kitasato University
Graduate School of Infection Control Sciences, Kitasato University
Toshiaki Sunazuka
Ōmura Satoshi Memorial Institute, Kitasato University
Graduate School of Infection Control Sciences, Kitasato University
Kenichi Nonaka
Ōmura Satoshi Memorial Institute, Kitasato University
Graduate School of Infection Control Sciences, Kitasato University
Takashi Yaguchi
Medical Mycology Research Center, Chiba University
Masato Iwatsuki
Ōmura Satoshi Memorial Institute, Kitasato University
Graduate School of Infection Control Sciences, Kitasato University

Keywords: antifungal activity, hakuhybotric acid, Hypomyces pseudocorticiicola

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Supplementary material

2022 Volume 68 Issue 4 Pages 200-206

DOI https://doi.org/10.2323/jgam.2022.03.002

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Abstract

A new antifungal polyketide, named hakuhybotric acid (1), was isolated from a cultured broth of a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008, together with two known analogs, F2928-1 (2) and Cladobotric acid E (3). Their structures were elucidated by MS and NMR analyses. Hakuhybotric acid was a new analog of Cladobotric acid where two epoxy groups in F2928-1 were replaced with olefins. All compounds showed antifungal activity against four different species of Aspergillus spp., the causative agents of aspergillosis. It was suggested that mycoparasitic fungi are a useful source to search antifungal drug lead compounds.

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