Processing and Application of Ceramics 2022 Volume 16, Issue 3, Pages: 207-217
https://doi.org/10.2298/PAC2203207M
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Incorporation of cerium oxide into hydroxyapatite/chitosan composite scaffolds for bone repair
Mutlu Büşra (Metallurgical and Materials Engineering Department, Bursa Technical University, Bursa, Turkey)
Çaylak Sena (Nanoscience and Nanoengineering Department, Istanbul Technical University, Istanbul, Turkey)
Duman Şeyma (Metallurgical and Materials Engineering Department, Bursa Technical University, Bursa, Turkey), seyma.duman@btu.edu.tr
This study reports on the production of chitosan-based composite scaffolds
reinforced with hydroxyapatite (HA) powders prepared with cerium oxide
(CeO2) with various concentrations (10, 20, 30 wt.%). Besides, the effect of
CeO2 additive on the microstructural,mechanical and bioactivity properties
of the composite scaffolds was investigated. The CeO2 reinforced HA powders
were synthesized having homogenous particle distribution via spray drying
process. The synthesized powders and the produced scaffolds were examined
using different characterization methods. From the results, it can be seen
that the scaffolds were significantly affected by amount of CeO2 additive.
An increase in the compressive strength is observed as the amount of CeO2
additive rises. Furthermore, the composite scaffolds possessed a high
mineralization ability of apatite in simulated body fluid (SBF). These
observations related to the composite scaffolds have considerable potency
for application in bone tissue engineering.
Keywords: cerium oxide, hydroxyapatite, spray drying, mechanical properties, bioactivity properties
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