doiSerbia

Flavonoids from mango leaves with antibacterial activity

Kanwal Qudsia (Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan)
Hussain Ishtiaq (Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan)
Siddiqui Latif Hamid (Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan)
Javaid Arshad (Institute of Mycology and Plant Pathology, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan)

Five flavonoids, viz. (-)-epicatechin-3-O-β-glucopyranoside (1), 5-hydroxy- 3-(4-hydroxylphenyl)pyrano[3,2-g]chromene-4(8H)-one (2), 6-(p-hydroxybenzyl) taxifolin-7-O-β-D-glucoside (tricuspid) (3), quercetin-3-O-α-glucopyranosyl-(1->2)-β-glucopyranoside (4) and (-)-epicatechin(2-(3,4-dihydroxyphenyl)- 3,4-dihydro-2H-chromene-3,5,7-triol) (5), were isolated from the leaves of mango (Mangifera indica L.). The antibacterial activity of different concentrations of these flavonoids (100, 300, 500, 700, 900 and 1000 ppm) was evaluated against four bacterial species, namely Lactobacillus sp., Escherichia coli, Azospirillium lipoferum and Bacillus sp. All the tested concentrations of the five flavonoids significantly reduced the growth of all the five tested bacterial species. However, differences in the antibacterial activity of the flavonoids were evident. Compound 1 exhibited the lowest antibacterial activity, resulting in a 7-75 % reduction in the growth of the different bacterial species. Compound 5 showed the greatest antibacterial activity and the different concentrations reduced the bacterial growth by 45-99.9%. A. lipoferum and Bacillus sp. showed the highest susceptibility to this compound. Compounds 2-4 also depicted pronounced antibacterial activity. Different concentrations of these compounds decreased bacterial growth by 52-96 %. From the present study, it can be concluded that compound 5 is the most effective of the tested flavonoids against A. lipoferum and Bacillus sp.

Keywords: antibacterial, Mangifera indica, mango, flavonoids, leaves