doiSerbia

Chemical constituents and antimicrobial activity of the ethanol extracts obtained from the flower, leaf and stem of Salvia officinalis L

Veličković Dragan T. (AD 'Zdravlje' Pharmaceutical and Chemical Industry, Vlajkova St. 199, YU-16000 Leskovac)
Ranđelović Novica V. (Faculty of Technology, Bulevar Oslobođenja St. 124, YU-16000 Leskovac)
Ristić Mihailo S. (Institute for Medicinal Plants Research 'Dr. Josif Pančić', Tadeuša Košćuška St. 1, YU-11000 Belgrade)
Veličković Ana S. (Medical Center 'Moša Pijade', Department of General Practice, Rade Končara St. 2, YU-16000 Leskovac)
Šmelcerović Andrija A. (Chemical Industry 'Nevena', Đorđa Stamenkovića St. bb., YU-16000 Leskovac, Yugoslavia)

In this paper a comparison of the chemical composition and antimicrobial action of the ethanol extracts from the flower, leaf and stem of the herbal species Salvia officinalis L. (Lamiaceae), originating from the southeast region of Serbia was carried out. The chemical composition of the extracts was determined by GC-FID and GC-MS analyses. Manool has the highest level of all the components (9.0–11.1 %). Antimicrobial activity was determined by the diffusion and dilution method, whereby the latter one was modified by use of cellulose discs, and it was applied for the determination of the minimal inhibitory (MIC) and minimal lethal concentrations (MLC). The leaf extract has a stronger antimicrobial activity than those of the flower and stem.

Keywords: Salvia officinalis L., Lamiaceae, extracts composition, manool, antimicrobial activity.