doiSerbia

Electrochemical characterization and determination of carbamazepine as pharmaceutical standard and tablet content on gold electrode

Trišović Nemanja P. (Faculty of Technology and Metallurgy, Belgrade)
Božić Bojan Đ. (Faculty of Technology and Metallurgy, Belgrade)
Petrović Slobodan D. (Faculty of Technology and Metallurgy, Belgrade)
Tadić Svetlana J. (Galenika a.d., Belgrade)
Avramov-Ivić Milka L. (ICTM, Institute of Electrochemistry, Belgrade)

The anodic behaviour of carbamazepine (CBZ), an anticonvulsant drug, has been studied on gold electrode in 0.1 mol dm-3 phosphate buffer of pH 7.0 by using cyclic voltammetry. It has been found that the value of the oxidative current of pure CBZ at +0.90 V is a linear function of the concentration in a range from 1.0×10-7 to 1.0×10−4 mol dm−3. The detection of CBZ in the concentration of 1.0×10-8 mol dm-3 is among the lowest that have been reported for this drug using voltammetric techniques. CBZ as a content of tablet Galepsine® has been quantitatively determined. It has also been demonstrated that the modification of gold electrode with bovine serum albumin (BSA) results in a decrease of the oxidative peak current due to the binding of the drug to BSA.

Keywords: carbamazepine, voltammetric determination, gold electrode

Projekat Ministarstva nauke Republike Srbije, br. 172013