doiSerbia

Evaluation of anti-inflammatory activity of some Libyan medicinal plants in experimental animals

Elmezogi Jamal (Faculty of Pharmacy, Tripoli University, Tripoli, Libya)
Zetrini Abdulmottaleb (National Center for Medical Research, Zawia, Libya)
Ben-Hussein Ghazala (Faculty of Pharmacy, Tripoli University, Tripoli, Libya)
Anwair Masoud (Faculty of Pharmacy, Tripoli University, Tripoli, Libya)
Gbaj Abdul (Faculty of Pharmacy, Tripoli University, Tripoli, Libya + National Center for Medical Research, Zawia, Libya)
El-Ashheb Mabrouka (Faculty of Medicine, Tripoli University, Tripoli, Libya)
Nahar Lutfun (Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE BH, England, UK)
Sarker Satyajit D. (Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, MA Building, Wolverhampton, England, UK)

Ballota pseudodictamnus (L.) Benth. (Lamiaceae), Salvia fruticosa Mill. (Lamiaceae) and Thapsia garganica L. (Apiaceae) are three well-known medicinal plants from the Libyan flora, which have long been used for the treatment of inflammations. The aim of the present study was to investigate, for the first time, the anti-inflammatory property of the methanol (MeOH) extracts of the aerial parts of these plants. Shade-dried and ground aerial parts of B. pseudodictamnus, S. fruticosa) and T. garganica were Soxhlet-extracted with MeOH. The extracts were concentrated by evaporation under reduced pressure at 40°C. The anti-inflammatory activity of the extracts was evaluated using the carrageenan-induced mice paw edema model. The administration of the extracts at a dose of 500 mg/kg body weight produced statistically significant inhibition (p < 0.05) of edema within 3 h of carrageenan administration. The results demonstrated significant anti-inflammatory properties of the test extracts. Among the extracts, the S. fruticosa extract exhibited the most significant inhibition of inflammation after 3 h (62.1%). Thus, S. fruticosa could be a potential source for the discovery and development of newer anti-inflammatory ‘leads’ for drug development. The anti-inflammatory activity of B. pseudodictamnus and S. fruticosa could be assumed to be related to high levels of phenolic compounds, e.g., flavonoids, present in these plants.

Keywords: Ballota pseudodictamnus, Salvia fruticosa, Thapsia garganica, carrageenan