Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Abstract
Opioid and opioid-like receptors are activated by a variety of endogenous peptides including [Met]enkephalin (met), [Leu]enkephalin (leu), β-endorphin (β-end), α-neodynorphin, dynorphin A (dynA), dynorphin B (dynB), big dynorphin (Big dyn), nociceptin/orphanin FQ (N/OFQ); endomorphin-1 and endomorphin-2 are also potential endogenous peptides. The Greek letter nomenclature for the opioid receptors, μ, δ and κ, is well established, and NC-IUPHAR considers this nomenclature appropriate, along with the symbols spelled out (mu, delta, and kappa), and the acronyms, MOP, DOP, and KOP. [116, 96, 88]. The human N/OFQ receptor, NOP, is considered 'opioid-related' rather than opioid because, while it exhibits a high degree of structural homology with the conventional opioid receptors [282], it displays a distinct pharmacology. Currently there are numerous clinically used drugs, such as morphine and many other opioid analgesics, as well as antagonists such as naloxone, however only for the μ receptor.
Published
16-Sep-2019
How to Cite
Borsodi, A., Bruchas, M., Caló, G., Chavkin, C., Christie, M. J., Civelli, O., Connor, M., Cox, B. M., Devi, L. A., Evans, C., Höllt, V., Henderson, G., Husbands, S., Kelly, E., Kieffer, B., Kitchen, I., Kreek, M.-J., Liu-Chen, L.-Y., Massot, D., Meunier, J.-C., Portoghese, P. S., Schulz, S., Shippenberg, T. S., Simon, E. J., Toll, L., Traynor, J. R., Ueda, H., Wong, Y. H., Zaveri, N. and Zimmer, A. (2019) “Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F50/2019.4.
Issue
Section
Summaries
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.