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Research Article

Development of phospholipid complex loaded self-microemulsifying drug delivery system to improve the oral bioavailability of resveratrol

    Xinxin Luo

    School of Chemistry & Chemical Engineering, Chongqing University, Chongqing, 401331, China

    ,
    Dandan Wang

    School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China

    ,
    Min Wang

    School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China

    ,
    Suya Deng

    School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China

    ,
    Yike Huang

    *Author for correspondence:

    E-mail Address: huangyike328@163.com

    College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China

    &
    Zhining Xia

    **Author for correspondence:

    E-mail Address: znxia@cqu.edu.cn

    School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China

    Published Online:https://doi.org/10.2217/nnm-2020-0422

    Aim: The aim of this study was to develop a formulation that combines a phospholipid complex (PC) and self-microemulsifying drug delivery system (SMEDDS) to improve the bioavailability of poorly water-soluble resveratrol (RES), called RPC-SMEDDS. Methods: RES-PC (RPC) and RPC-SMEDDS were optimized by orthogonal experiment and central composite design, respectively. The characteristics and mechanism of intestinal absorption were studied by Ussing chamber model. The pharmacokinetics was evaluated in rats. Results: RES was the substrate of MRP2 and breast cancer resistance protein (BCRP) rather than P-gp. The prepared RPC-SMEDDS prevented the efflux mediated by MRP2 and BCRP and improved the bioavailability of RES. Conclusion: These results suggested that the combination system of PC and SMEDDS was a promising method to improve the oral bioavailability of RES.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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