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The utility of 68Ga-DOTATATE positron-emission tomography/computed tomography in the diagnosis, management, follow-up and prognosis of neuroendocrine tumors

    Amit Tirosh

    *Author for correspondence:

    E-mail Address: amit.tirosh@nih.gov

    Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Sackler Faculty of Medicine, Tel Aviv University, Israel

    &
    Electron Kebebew

    Sackler Faculty of Medicine, Tel Aviv University, Israel

    Department of Surgery, The George Washington University School of Medicine & Health Sciences, Washington DC, USA

    Published Online:https://doi.org/10.2217/fon-2017-0393

    Neuroendocrine tumors (NETs) are rare neoplasms that emerge mainly from the GI tract, pancreas and respiratory tract. The incidence of NETs has increased more than sixfold in the last decades. NETs typically express somatostatin receptors on their cell surface, which can be targeted by ‘cold’ somatostatin analogs for therapy or by ‘hot’ radiolabeled somatostatin analogs for tumor localization and treatment. 68-Gallium-DOTA peptides (DOTATATE, DOTATOC, DOTANOC) positron emission tomography/computed tomography is a highly accurate imaging modality for NETs that has been found to be more sensitive for NET detection than other imaging modalities. In the current review, we will discuss the clinical utility of 68-Gallium-DOTATATE positron emission tomography/computed tomography for the diagnosis and management of patients with NETs.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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