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Early clinical management of acute CNS infections: a prospective cohort study

    Yueying Huang‡

    Department of Emergency Medicine, Huashan Hospital, Fudan University, Shanghai 200040, PR China

    ‡These authors contributed equally to this work.

    Search for more papers by this author

    ,
    Shuaiyue Dong‡

    Department of Emergency Medicine, Huashan Hospital, Fudan University, Shanghai 200040, PR China

    ‡These authors contributed equally to this work.

    Search for more papers by this author

    ,
    Liangliang Zhou

    Department of Emergency Medicine, Huashan Hospital, Fudan University, Shanghai 200040, PR China

    ,
    Senlin Ma

    Department of Emergency Medicine, Huashan Hospital, Fudan University, Shanghai 200040, PR China

    ,
    Zongyan Wang

    Department of Emergency Medicine, Huashan Hospital, Fudan University, Shanghai 200040, PR China

    ,
    Xin Jin

    Department of Emergency Medicine, Huashan Hospital, Fudan University, Shanghai 200040, PR China

    &
    Minjie Yang

    *Author for correspondence:

    E-mail Address: tracy_yang99@hotmail.com

    Department of Emergency Medicine, Huashan Hospital, Fudan University, Shanghai 200040, PR China

    Published Online:https://doi.org/10.2217/fmb-2019-0211

    Aim: To explore early management and clinical predictors of patients with suspected CNS infections. Methods: In a prospective cohort study of 125 adult patients with suspected CNS infections, clinical features and early management time points were compared between groups with and without confirmed CNS infections. Results: The door-to-lumbar puncture time was associated with the initial Glasgow Coma Scale score, the confirmed diagnosis and the time to change empirical treatment. Multivariate analysis indicated that the initial Glasgow Coma Scale score was an independent risk factor for prognosis. Conclusion: Lumbar puncture plays a crucial role in early management of CNS infections. Patients with CNS infection who have disturbances of consciousness should receive particular attention.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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