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Using the galectin-3 test to predict mortality in heart failure patients: a systematic review and meta-analysis

    Yueh-Sheng Chen

    Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

    ,
    Weng-Tein Gi

    School of Public Health, Heidelberg University, Heidelberg, Germany

    ,
    Tin-Yun Liao

    Department of Rehabilitation & Physical Medicine, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan

    ,
    Meng-Tse Gabriel Lee

    Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan

    ,
    Si-Huei Lee

    Department of Rehabilitation & Physical Medicine, Taipei Veteran General Hospital, Taipei, Taiwan

    ,
    Wan-Ting Hsu

    Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan

    ,
    Shy-Shin Chang

    *Author for correspondence:

    E-mail Address: sschang0529@gmail.com

    Department of Family Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan

    &
    Chien-Chang Lee

    **Author for correspondence:

    E-mail Address: cclee100@gmail.com

    Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan

    Department of Emergency Medicine & Department of General Medicine, National Taiwan University Hospital Yunlin Branch, Douliou, Taiwan

    Published Online:https://doi.org/10.2217/bmm.15.121

    Aim: Galectin-3 (Gal-3) is a new biomarker for assessing prognosis of heart failure (HF) patients. This systemic review and meta-analysis aims to examine Gal-3’s ability in assessing prognosis of HF patients. Method: We searched MEDLINE and Embase up to November 2014. Test performance characteristics were summarized using forest plots and hierarchical summary receiver operating characteristic curves. Results: The diagnostic odds ratio of Gal-3 in predicting mortality in chronic HF patients was 2.36 (95% CI: 1.71–3.26) and 2.30 (95% CI: 1.76–3.01) in acute HF patients. Conclusion: Elevated levels of Gal-3 are associated with mortality in both acute and chronic HF patients. However, current evidence does not support sole use of Gal-3 for prognosis evaluation of HF patients.

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