The purpose of this study was to investigate the influence of the cross-sectional form and area of the connector on fracture resistance in three-unit zirconia fixed partial denture (FPD) frameworks for the upper anterior region. Sixty FPD framework specimens were fabricated using the CAD/CAM system. The cross-sectional form (Type I, II, or III) and area (9.0, 7.0, 5.0, or 3.0 mm²) of the connectors differed. The specimens were fixed to a jig capable of applying a load axially to the abutment teeth at an angle of 135 degrees. Each specimen was subjected to fracture load measurements using a universal testing machine and cross-sectional microscopic examination. Fracture load fell significantly with a decrease in cross-sectional area (p <0.01). In terms of cross-sectional form, an isosceles triangle with a gingival base yielded the highest fracture load. These results suggest that the connector of a three-unit zirconia-based FPD framework for the upper anterior region should be triangular, have a gingival base, sufficient height in the loading direction, and a cross-sectional area of >5.0 mm².