Abstract
Allergic rhinitis and asthma are inflammatory airway allergic diseases caused by Th2-driven immune response. Several studies have shown that multipotent adipose-derived stem cells (ASCs) can exert profound immunosuppressive effects via modulation of both cellular and innate immune pathway, especially immunosuppressive effect on T cell activities. ASCs ability to be readily isolated from a number of adipose tissues and expanded ex vivo makes them attractive candidate for use in clinical therapy in the context of allogeneic transplantation, in particular to modulate graft-versus-host disease and graft rejection. The authors have investigated whether ASCs can inhibit Th2-dependent airway allergic disease in the mouse model. In this article we review recent experimental data and discuss about the mechanisms by which ASCs inhibit allergic airway inflammation via immunomodulation from a Th2 to a Th1-biased response in the mouse model.
Keywords: Immunosuppression, adipose tissue, stem cells, asthma, allergic rhinitis
Current Stem Cell Research & Therapy
Title: Immunomodulatory Effects of Adipose-Derived Stem Cells in Airway Allergic Diseases
Volume: 5 Issue: 2
Author(s): Kyu-Sup Cho and Hwan-Jung Roh
Affiliation:
Keywords: Immunosuppression, adipose tissue, stem cells, asthma, allergic rhinitis
Abstract: Allergic rhinitis and asthma are inflammatory airway allergic diseases caused by Th2-driven immune response. Several studies have shown that multipotent adipose-derived stem cells (ASCs) can exert profound immunosuppressive effects via modulation of both cellular and innate immune pathway, especially immunosuppressive effect on T cell activities. ASCs ability to be readily isolated from a number of adipose tissues and expanded ex vivo makes them attractive candidate for use in clinical therapy in the context of allogeneic transplantation, in particular to modulate graft-versus-host disease and graft rejection. The authors have investigated whether ASCs can inhibit Th2-dependent airway allergic disease in the mouse model. In this article we review recent experimental data and discuss about the mechanisms by which ASCs inhibit allergic airway inflammation via immunomodulation from a Th2 to a Th1-biased response in the mouse model.
Export Options
About this article
Cite this article as:
Cho Kyu-Sup and Roh Hwan-Jung, Immunomodulatory Effects of Adipose-Derived Stem Cells in Airway Allergic Diseases, Current Stem Cell Research & Therapy 2010; 5 (2) . https://dx.doi.org/10.2174/157488810791268681
DOI https://dx.doi.org/10.2174/157488810791268681 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Comprehensive Review on Preclinical Evidence-based Neuroprotective
Potential of <i>Bacopa monnieri</i> against Parkinson's Disease
Current Drug Targets Cytokine-Induced Inflammatory Liver Injuries
Current Molecular Medicine A Bibliometric Analysis of Global Research on Lophomonas Spp. in Scopus (1933-2019)
Infectious Disorders - Drug Targets Interferon-γ as a Possible Target in Chronic Asthma
Inflammation & Allergy - Drug Targets (Discontinued) Patent Annotations
Recent Patents on Inflammation & Allergy Drug Discovery Assessment of Airway Inflammation by Exhaled Breath Condensate and Impedance Due to Gastroesophageal Reflux Disease (GERD)
Inflammation & Allergy - Drug Targets (Discontinued) Advances in Development of Phosphatidylinositol 3-Kinase Inhibitors
Current Medicinal Chemistry Cough Recording Technology
Current Respiratory Medicine Reviews Extensive Phytochemistry, Comprehensive Traditional Uses, and Critical Pharmacological Profile of the Great Mullein: Verbascum thapsus L
The Natural Products Journal Renin Angiotensin System (RAS) and Immune System Profile in Specific Subgroups with COVID-19
Current Medicinal Chemistry Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review
Current Neuropharmacology Appraisal of Anti-Arthritic and Anti-Inflammatory Potential of Folkloric Medicinal Plant <i>Peganum harmala</i>
Endocrine, Metabolic & Immune Disorders - Drug Targets Role of Beta2 Agonists in Respiratory Medicine with Particular Attention to Novel Patents and Effects on Endocrine System and Immune Response
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Mangrove Plants as a Source of Bioactive Compounds: A Review
The Natural Products Journal Adipose-Derived Stromal/Stem Cells (ASC) in Regenerative Medicine: Pharmaceutical Applications
Current Pharmaceutical Design Success of Inhaled Corticosteroids in the Treatment of Non-Asthmatic Respiratory Diseases
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The cAMP-Dependent Protein Kinase Pathway as Therapeutic Target – Possibilities and Pitfalls
Current Topics in Medicinal Chemistry Established and In-trial GPCR Families in Clinical Trials: A Review for Target Selection
Current Drug Targets Evaluating the Effect of Cinnarizine on Promastigotes and Amastigotes forms of Leishmania major
Infectious Disorders - Drug Targets Application of Radioisotopes in Inflammation
Current Medicinal Chemistry