Abstract
From various studies it is now clear that in addition to nucleic acids, enediynes also target other biomolecules, the most prominent of which are the proteins. Since a major portion of currently available drug targets are proteins (enzymes and receptors), this aspect of enediyne chemistry has opened a new window for further exploitation. Newer enediyne-based therapeutics targeting proteins may be possible to design. Moreover, the toxicity of the natural enediynes may arise from the non-selective protein cleavages. Substantial progress has been made to understand the nature of interaction between enediynes and proteins. This article is an attempt to discuss the developments in this area.
Keywords: Bergman cyclization, cycloaromatization, diradicals, dna, enediynes, protein.
Letters in Drug Design & Discovery
Title:Proteins as Alternate Targets of Enediynes
Volume: 12 Issue: 7
Author(s): Hussam M. Bdour, Snigdha Roy and Amit Basak
Affiliation:
Keywords: Bergman cyclization, cycloaromatization, diradicals, dna, enediynes, protein.
Abstract: From various studies it is now clear that in addition to nucleic acids, enediynes also target other biomolecules, the most prominent of which are the proteins. Since a major portion of currently available drug targets are proteins (enzymes and receptors), this aspect of enediyne chemistry has opened a new window for further exploitation. Newer enediyne-based therapeutics targeting proteins may be possible to design. Moreover, the toxicity of the natural enediynes may arise from the non-selective protein cleavages. Substantial progress has been made to understand the nature of interaction between enediynes and proteins. This article is an attempt to discuss the developments in this area.
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Cite this article as:
Bdour M. Hussam, Roy Snigdha and Basak Amit, Proteins as Alternate Targets of Enediynes, Letters in Drug Design & Discovery 2015; 12 (7) . https://dx.doi.org/10.2174/1570180812666150213224756
DOI https://dx.doi.org/10.2174/1570180812666150213224756 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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