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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Perspective

Mitophagy and Neuroinflammation: A Compelling Interplay

Author(s): Nikolaos Charmpilas, Evandro Fei Fang and Konstantinos Palikaras*

Volume 21, Issue 7, 2023

Published on: 13 March, 2023

Page: [1477 - 1481] Pages: 5

DOI: 10.2174/1570159X20666220628153632

Abstract

Mitochondria are the main sites of energy production and a major source of metabolic stress. Not surprisingly, impairment of mitochondrial homeostasis is strongly associated with the development and progression of a broad spectrum of human pathologies, including neurodegenerative disorders. Mitophagy mediates the selective degradation of damaged organelles, thus promoting cellular viability and tissue integrity. Defective mitophagy triggers cellular senescence and prolonged neuroinflammation, leading eventually to cell death and brain homeostasis collapse. Here, we survey the intricate interplay between mitophagy and neuroinflammation, highlighting that mitophagy can be a focal point for therapeutic interventions to tackle neurodegeneration.

Keywords: Ageing, energy homeostasis, immunity, inflammation, metabolism, mitochondria, mitophagy, neurodegeneration.

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Graphical Abstract

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