Abstract
Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, “oxidative stress” implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidativemodified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.
Keywords: Reactive Oxygen Species (ROS), Oxidative Stress, Lipid Oxidation, DNA Oxidation, Protein Oxidation, Oral Carcinogenesis, OSCC, Leukoplakia, Lichen Planus, Submucous Fibrosis, tobacco, infection, intraoral cancer, chemotherapy, radiotherapy
Current Molecular Medicine
Title:Oxidative Stress Based-Biomarkers in Oral Carcinogenesis: How Far Have We Gone?
Volume: 12 Issue: 6
Author(s): R. Hanafi, I. Anestopoulos, G. P. Voulgaridou, R. Franco, A. G. Georgakilas, D. Ziech, V. Malamou-Mitsi, A. Pappa and M. I. Panayiotidis
Affiliation:
Keywords: Reactive Oxygen Species (ROS), Oxidative Stress, Lipid Oxidation, DNA Oxidation, Protein Oxidation, Oral Carcinogenesis, OSCC, Leukoplakia, Lichen Planus, Submucous Fibrosis, tobacco, infection, intraoral cancer, chemotherapy, radiotherapy
Abstract: Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, “oxidative stress” implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidativemodified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.
Export Options
About this article
Cite this article as:
Hanafi R., Anestopoulos I., P. Voulgaridou G., Franco R., G. Georgakilas A., Ziech D., Malamou-Mitsi V., Pappa A. and I. Panayiotidis M., Oxidative Stress Based-Biomarkers in Oral Carcinogenesis: How Far Have We Gone?, Current Molecular Medicine 2012; 12 (6) . https://dx.doi.org/10.2174/156652412800792598
DOI https://dx.doi.org/10.2174/156652412800792598 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Role of Venous Abnormalities in Neurological Disease
Reviews on Recent Clinical Trials The Use of PET for Radiotherapy
Current Medical Imaging Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer Cells
Current Medicinal Chemistry Nanotechology-Based Strategies to Enhance the Efficacy of Photodynamic Therapy for Cancers
Current Drug Metabolism Targeted Drug Delivery to the Virus-Infected Airway; Complications and Remedies
Current Drug Delivery Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy
Current Medicinal Chemistry Can Diabetes Heal?- From Observations to Perspectives
Current Diabetes Reviews Approaching the Increasing Complexity of Non-small Cell Lung Cancer Taxonomy
Current Pharmaceutical Design Characterization and Management of Cutaneous Side Effects Related to the Immunosuppressive Treatment in Solid Organ Recipients
Current Drug Targets β -Glucans and their Applications in Cancer Therapy: Focus on human studies
Anti-Cancer Agents in Medicinal Chemistry Current Management of Vascular Tumors in the Neonate
Current Pediatric Reviews Cytoskeletal Alterations that Confer Resistance to Anti-tubulin Chemotherapeutics
Anti-Cancer Agents in Medicinal Chemistry The Association of Chemotherapy and Radiotherapy: Biological Rationale
Current Drug Therapy T Cell Replicative Senescence in Human Aging
Current Pharmaceutical Design Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops
Current Signal Transduction Therapy Membrane Transporters as Determinants of the Pharmacology of Platinum Anticancer Drugs
Current Cancer Drug Targets Characterization of Pharmaceutical IgG and Biosimilars Using Miniaturized Platforms and LC-MS/MS
Current Pharmaceutical Biotechnology Biology of PPARγ in Cancer: A Critical Review on Existing Lacunae
Current Molecular Medicine Histone Modifications, Stem Cells and Prostate Cancer
Current Pharmaceutical Design Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer
Current Protein & Peptide Science