Abstract
Focal cerebral ischemia induces neurogenesis in the subventricular zone (SVZ) of the adult human brain. Neurogenesis is controlled by proliferation, differentiation, and migration of neural progenitor cells. This article reviews emerging data that changes of cell cycle kinetics of neural progenitor cells induced by stroke contribute to increased neural progenitor cell proliferation and that gene profiles control proliferation, differentiation, and migration of neural progenitor cells within the SVZ niche. A better understanding of gene profiles that control the biological function of adult SVZ neural progenitor cells could lead to more selective and effective treatments to enhance neurogenesis during stroke recovery.
Keywords: Cerebral ischemia, neurogenesis, gene profiles
Current Molecular Medicine
Title: Gene Profiles within the Adult Subventricular Zone Niche:Proliferation, Differentiation and Migration of Neural Progenitor Cells in the Ischemic Brain
Volume: 7 Issue: 5
Author(s): Rui Lan Zhang, Zheng Gang Zhang and Michael Chopp
Affiliation:
Keywords: Cerebral ischemia, neurogenesis, gene profiles
Abstract: Focal cerebral ischemia induces neurogenesis in the subventricular zone (SVZ) of the adult human brain. Neurogenesis is controlled by proliferation, differentiation, and migration of neural progenitor cells. This article reviews emerging data that changes of cell cycle kinetics of neural progenitor cells induced by stroke contribute to increased neural progenitor cell proliferation and that gene profiles control proliferation, differentiation, and migration of neural progenitor cells within the SVZ niche. A better understanding of gene profiles that control the biological function of adult SVZ neural progenitor cells could lead to more selective and effective treatments to enhance neurogenesis during stroke recovery.
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Cite this article as:
Rui Lan Zhang , Zheng Gang Zhang and Michael Chopp , Gene Profiles within the Adult Subventricular Zone Niche:Proliferation, Differentiation and Migration of Neural Progenitor Cells in the Ischemic Brain, Current Molecular Medicine 2007; 7 (5) . https://dx.doi.org/10.2174/156652407781387136
DOI https://dx.doi.org/10.2174/156652407781387136 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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