Abstract
Histone Deacetylases (HDACs) enzymes are critical in regulating gene expression and transcription. They also play a fundamental role in regulating cellular activities such as cell proliferation, survival and differentiation. Inhibition of HDACs has generated many fascinating results including a new strategy in human cancer therapy. HDAC Inhibitors (HDACIs) like SAHA, TSA are emerging as new promising drugs for various anti-inflammatory and CNS-disorders. This review, along with chemical classification, emphasizes on the therapeutic potential of various HDACIs against different diseases.
Keywords: Histone Deacetylase, HDAC inhibitor, chemistry, therapeutic applications, Enzyme Histone acetyltransferases, HAT, Class III HDACs, sirtuins, nu-clear receptor co-repressor, N-coR, Silencing Mediator, Thyroid receptors, SMRT, HDAC enzyme, aliphatic chain, Large hydrophobic region, Hydroxamic acids, trichostatin, TSA, suberoylanilide hydroxamic acid, SAHA, oxamflatin, Cyclic tetrapeptides, Benzamides, MS-27-275, Short-chain fatty acids, butyrates, Streptomyces hygro-scopicus, NVP-LAQ824, LAQ824, PDX 101, LDH589, Depsipeptide FK228, Chromobacterium violaceum, Apicidin, tubacin, Vorinostat, suberoylanilide hy-droxamic acid, Valproic acid, VPA, Trichostatin A
Mini-Reviews in Medicinal Chemistry
Title: HDAC Inhibitors-New Generation of Target Specific Treatment
Volume: 10 Issue: 13
Author(s): A. V. Chavan and R. R. Somani
Affiliation:
Keywords: Histone Deacetylase, HDAC inhibitor, chemistry, therapeutic applications, Enzyme Histone acetyltransferases, HAT, Class III HDACs, sirtuins, nu-clear receptor co-repressor, N-coR, Silencing Mediator, Thyroid receptors, SMRT, HDAC enzyme, aliphatic chain, Large hydrophobic region, Hydroxamic acids, trichostatin, TSA, suberoylanilide hydroxamic acid, SAHA, oxamflatin, Cyclic tetrapeptides, Benzamides, MS-27-275, Short-chain fatty acids, butyrates, Streptomyces hygro-scopicus, NVP-LAQ824, LAQ824, PDX 101, LDH589, Depsipeptide FK228, Chromobacterium violaceum, Apicidin, tubacin, Vorinostat, suberoylanilide hy-droxamic acid, Valproic acid, VPA, Trichostatin A
Abstract: Histone Deacetylases (HDACs) enzymes are critical in regulating gene expression and transcription. They also play a fundamental role in regulating cellular activities such as cell proliferation, survival and differentiation. Inhibition of HDACs has generated many fascinating results including a new strategy in human cancer therapy. HDAC Inhibitors (HDACIs) like SAHA, TSA are emerging as new promising drugs for various anti-inflammatory and CNS-disorders. This review, along with chemical classification, emphasizes on the therapeutic potential of various HDACIs against different diseases.
Export Options
About this article
Cite this article as:
V. Chavan A. and R. Somani R., HDAC Inhibitors-New Generation of Target Specific Treatment, Mini-Reviews in Medicinal Chemistry 2010; 10 (13) . https://dx.doi.org/10.2174/13895575110091263
DOI https://dx.doi.org/10.2174/13895575110091263 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Harnessing Impaired Energy Metabolism in Cancer Cell: Small Molecule- Mediated Ways to Regulate Tumorigenesis
Anti-Cancer Agents in Medicinal Chemistry Neurotrophic Factor Treatment After Spinal Root Avulsion Injury
Central Nervous System Agents in Medicinal Chemistry Genetic Surgery - A Right Strategy to Attack Cancer
Current Gene Therapy Illuminating microRNA Transcription from the Epigenome
Current Genomics The Interaction of GLUT1 and FOXM1 Leads to a Poor Prognosis in Colorectal Cancer
Anti-Cancer Agents in Medicinal Chemistry MATra - Magnet Assisted Transfection: Combining Nanotechnology and Magnetic Forces to Improve Intracellular Delivery of Nucleic Acids
Current Pharmaceutical Biotechnology Effects of Hypoxia and Ischemia on MicroRNAs in the Brain
Current Medicinal Chemistry Pieces of the Complex Puzzle of Cancer Cell Energy Metabolism: An Overview of Energy Metabolism and Alternatives for Targeted Cancer Therapy
Current Medicinal Chemistry 1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology
Current Pharmaceutical Design Inhibitors of the Sphingosine Kinase Pathway as Potential Therapeutics
Current Cancer Drug Targets An Insight into Purine, Tyrosine and Tryptophan Derived Marine Antineoplastic Alkaloids
Anti-Cancer Agents in Medicinal Chemistry NO Chimeras as Therapeutic Agents in Alzheimers Disease
Current Alzheimer Research Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins
Current Molecular Medicine Diabetes Mellitus: Channeling Care through Cellular Discovery
Current Neurovascular Research Prospectives of Antihypertensive Nano-ceuticals as Alternative Therapeutics
Current Drug Targets TRPC Channels and their Implications for Neurological Diseases
CNS & Neurological Disorders - Drug Targets Substance P and Alzheimer’s Disease: Emerging Novel Roles
Current Alzheimer Research Cerebral Amyloidoses: Molecular Pathways and Therapeutic Challenges
Current Medicinal Chemistry Therapeutic Potential of Multifunctional Tacrine Analogues
Current Neuropharmacology Electromagnetic Energy as a Bridge Between Atomic and Cellular Levels in the Genetics Approach to Cancer Treatment
Current Topics in Medicinal Chemistry