Abstract
The tetracyclic indolo[3,2-b]quinoline ring system constitutes an important structural moiety in natural products exhibiting numerous biological activities. In particular, indolo [3, 2-b]quinoline, commonly known as linear quindoline is of particular interest, because of its rigid structure and scope of derivatization. Although the core linear quindoline skeleton shows little or no activity in several biological systems, introduction of a methyl group on the N-5 atom leading to cryptolepine induces remarkable activity against a broad spectrum of biological targets. A number of analogs of quindoline and cryptolepine have been synthesized, incorporating various functional groups on the core quindoline skeleton leading to improved biological activities. In this review, we describe various synthetic methodologies leading to the quindoline scaffold, the biological activities and the structure activity relationships (SAR) of quindoline derivatives toward different disease states to give a better picture of the importance of this moiety in medicinal chemistry.
Keywords: Cryptolepine, indoloquinolines, synthesis, structure-activity relationship (SAR) studies
Mini-Reviews in Medicinal Chemistry
Title: Indolo[3,2-b]quinolines: Synthesis, Biological Evaluation and Structure Activity-Relationships
Volume: 8 Issue: 6
Author(s): Eyunni V.K. Suresh Kumar, Jagan R. Etukala and Seth Y. Ablordeppey
Affiliation:
Keywords: Cryptolepine, indoloquinolines, synthesis, structure-activity relationship (SAR) studies
Abstract: The tetracyclic indolo[3,2-b]quinoline ring system constitutes an important structural moiety in natural products exhibiting numerous biological activities. In particular, indolo [3, 2-b]quinoline, commonly known as linear quindoline is of particular interest, because of its rigid structure and scope of derivatization. Although the core linear quindoline skeleton shows little or no activity in several biological systems, introduction of a methyl group on the N-5 atom leading to cryptolepine induces remarkable activity against a broad spectrum of biological targets. A number of analogs of quindoline and cryptolepine have been synthesized, incorporating various functional groups on the core quindoline skeleton leading to improved biological activities. In this review, we describe various synthetic methodologies leading to the quindoline scaffold, the biological activities and the structure activity relationships (SAR) of quindoline derivatives toward different disease states to give a better picture of the importance of this moiety in medicinal chemistry.
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Cite this article as:
Suresh Kumar V.K. Eyunni, Etukala R. Jagan and Ablordeppey Y. Seth, Indolo[3,2-b]quinolines: Synthesis, Biological Evaluation and Structure Activity-Relationships, Mini-Reviews in Medicinal Chemistry 2008; 8 (6) . https://dx.doi.org/10.2174/138955708784534418
DOI https://dx.doi.org/10.2174/138955708784534418 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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